ID W7FWJ1_PLAFA Unreviewed; 932 AA.
AC W7FWJ1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Protein SEY1 homolog {ECO:0000256|HAMAP-Rule:MF_03109};
DE EC=3.6.5.- {ECO:0000256|HAMAP-Rule:MF_03109};
GN ORFNames=PFAG_05232 {ECO:0000313|EMBL:EUT78657.1};
OS Plasmodium falciparum Santa Lucia.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=478859 {ECO:0000313|EMBL:EUT78657.1};
RN [1] {ECO:0000313|EMBL:EUT78657.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Santa Lucia {ECO:0000313|EMBL:EUT78657.1};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Santa Lucia.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable GTP-binding protein involved in generating and
CC maintaining the structure of the tubular endoplasmic reticulum network.
CC {ECO:0000256|ARBA:ARBA00029381}.
CC -!- FUNCTION: Probable GTP-binding protein that may be involved in cell
CC development. {ECO:0000256|HAMAP-Rule:MF_03109}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC {ECO:0000256|HAMAP-Rule:MF_03109}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_03109}.
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DR EMBL; KE123511; EUT78657.1; -; Genomic_DNA.
DR AlphaFoldDB; W7FWJ1; -.
DR EnsemblProtists; EUT78657; EUT78657; PFAG_05232.
DR Proteomes; UP000030666; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR CDD; cd01851; GBP; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_03109; Sey1; 1.
DR InterPro; IPR030386; G_GB1_RHD3_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008803; RHD3/Sey1.
DR InterPro; IPR046758; Sey1/RHD3-like_3HB.
DR PANTHER; PTHR45923; PROTEIN SEY1; 1.
DR PANTHER; PTHR45923:SF2; PROTEIN SEY1; 1.
DR Pfam; PF05879; RHD3_GTPase; 1.
DR Pfam; PF20428; Sey1_3HB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51715; G_GB1_RHD3; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|HAMAP-Rule:MF_03109};
KW GTP-binding {ECO:0000256|HAMAP-Rule:MF_03109};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_03109};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_03109};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_03109};
KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_03109, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_03109,
KW ECO:0000256|SAM:Phobius}.
FT TOPO_DOM 1..843
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03109"
FT TRANSMEM 846..864
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 865..867
FT /note="Lumenal"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03109"
FT TRANSMEM 871..889
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 889..932
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03109"
FT DOMAIN 34..280
FT /note="GB1/RHD3-type G"
FT /evidence="ECO:0000259|PROSITE:PS51715"
FT BINDING 44..51
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03109"
SQ SEQUENCE 932 AA; 110023 MW; D8603ED5AF5430EF CRC64;
MEKGVEKTQI IDYDGNVIED LKEWMIDNKL NDLGFSYNVI AVLGSQSSGK STLLNNLFKT
SFDVMNTKQG HSQTTKGLWL SYDKFDDETN NSSSFFKLKK KNKPTLILDV EGTDSKERGD
NRLTFEHRSA LFCLALADCV IVNLWYHSLG NFTASNYGLL KTVMEVNLEL FQQEKNSPKT
ILLFTVRDWF EEFAPIEVVR NKILDEYINK IWKEMKKPKE AEKLNINNFF IIEVVGLSHG
IIKKEDFLKD VNNLRDKWIN NLRPSKYSRN IPSDGFAQYC NNIWNTIVKQ SQLDIPSQKE
MLSTFRCQEI KNNVINNINK EIKEKSIESH NKVIENFKEW AEKNIIQKCL DDYFKDASRY
KENICLRTSQ ELLDYLFTQL QAIVDNNLQY IQRTLCTKFF NELSNMYKIC TIEKNTFSFS
RDSNLKTVKD NNKNTSHEDI KRDLLNNNQD KCVHLWSNFL YNADKLEYFT FCNFYENYEK
SNIEIKTNMK NDDNLKNDAH NNITTHQFNY KPTLSVLSTS IYKDSNRIRN IQCGILLNKT
RQTIKNSFKN MDTYLLTTKN TEEYWNNTVQ LVLKLQDNIN THLTKCFINL KGTNHNNLNI
YNDDMMYNND DMVFNNNDDD NNNNNNNNNN NYYYYNKNDD ANLSKDENYN NKFSFSLTNE
KGIFQNINNN NEGSDEICYT NALKKIDLIK NKQVYKSTIN EDINNKLQNK KYIHELKNYY
LDEIMDVLKN KLDEISENLA TIIIQRFESV FNYDEYEQPR QWRDISMAEL KKIFLKSKNY
AFLIIDILQK NIKVELIDDY LPNNFIKDEI IEKGKIKAKR RIQEICRDAQ YIQETGSKMS
LKNVPVVFWI ILLLFGWNEI LFFIRMFFKL NVILPLFFAA AFIVSTFVYN GNTQALSYIN
KIIFYMAKNS YNFFKHIQAI SNPPPKNVQK QE
//
