ID W7FZU1_PLAFA Unreviewed; 1154 AA.
AC W7FZU1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=PFAG_04999 {ECO:0000313|EMBL:EUT80358.1};
OS Plasmodium falciparum Santa Lucia.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=478859 {ECO:0000313|EMBL:EUT80358.1};
RN [1] {ECO:0000313|EMBL:EUT80358.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Santa Lucia {ECO:0000313|EMBL:EUT80358.1};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Santa Lucia.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC PRP16 sub-subfamily. {ECO:0000256|ARBA:ARBA00038040}.
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DR EMBL; KE123509; EUT80358.1; -; Genomic_DNA.
DR AlphaFoldDB; W7FZU1; -.
DR EnsemblProtists; EUT80358; EUT80358; PFAG_04999.
DR Proteomes; UP000030666; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF91; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 489..652
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 729..902
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 134909 MW; AB3B020CF22498C8 CRC64;
MIAKSYVYSD SSSDGNKKNN DKIQTGFLYN EKKNEKTLEF KRRKVNKINK KLTTDDVKSN
IFKKIDTFEE ASFKKDKVSK RYLNNNEKEK YYKDRDKNKI KKNNIKDKHV NQKYNIYNSS
TSPDNSDIDN LYNHKENKNN HKYNKSDYSE DSINISINIK NDESNKYNLS NKQHHNRYSN
KTFEKDEKQK KDYYKKNNDK ILDEIWYTKE DEFVDSFYNM DIEATYEKEK KMINNLKTRI
NSNTGKKVNQ KNLDNNLWEL NKLKQGGVTS TYNKLQLEKI NEANVTNEIK KIVLTRTVNP
PFIDKFKSYN KRFVNIEQRN NFDDQKSEKK KSDNINNDKY YSNKPIQSTS YSTVVKDETC
DFVKAAKKGS EFLKYFKSEN EKSKARDRYW EISNSKLGEL LKLYKNKKKN KNDNTSKEDY
DNISYNSSEN NKEDDNGSDV FDYKKDKIYS SLFNIENNNK DKKNTLKDKE ELLKLKESLP
IYKSKHELLD AVYNNNIIII VGETGSGKTT QIVQYLYEEG YHRNGIICCT QPRRVAAVSV
AYRVSYEMNV DIGSLVGYTI RFEDNTTKDT KIRYVTDGIL LRETLNDKEL DKYSVIIMDE
AHERSINTDV LLGILKNICL KRNDLKLIVT SATIDAKKFS AFFGNAPIYN IQGRTFKVHI
EYLRTPCNDY IECAVQKAIQ IHVSDNNYDN NFGDILIFMT GQEDINATCY LLSERFYEVY
ESYKESKNNK KDTINKIKNI LNEDNNNNNN NNNDSNIKKK VDGDNNTNDH MIYPFYIFPI
YSQLSSEQQS KIFKKYDLRK IIVSTNIAET SLTLDGIKYV IDTGYCKLKV YNQTIGMDVL
QVTPISQANA NQRSGRAGRT GAGICYRLYT ENTFLCDLYQ NNIPEIQRSN LSNVVLLLKS
LHVQNLFEFD FIDVPSKESI INSLHELWVL GAINNEGNLT DIGRKMVQFP LDPPLSKIVI
YSQNFQCTKE ILIIVSMLSS PSIFLESKEN NESIESKKEK FTVPESDHLT LLNIYLQWRS
HNYSYSWCTK NFIQYKALNK AKEVYSQLID IIKTLNIKNV SCDNKWELIR KTICSGYFHN
AAKLKSFSEY INLRTNVSCH VHPNSSLYNI GYTPDYVIYQ EIVFTTKEYM RNVTTVDPEW
LCELGPLFFY MKNV
//
