ID W7G014_PLAFA Unreviewed; 545 AA.
AC W7G014;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN ORFNames=PFAG_02013 {ECO:0000313|EMBL:EUT87189.1};
OS Plasmodium falciparum Santa Lucia.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=478859 {ECO:0000313|EMBL:EUT87189.1};
RN [1] {ECO:0000313|EMBL:EUT87189.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Santa Lucia {ECO:0000313|EMBL:EUT87189.1};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Santa Lucia.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; KE123491; EUT87189.1; -; Genomic_DNA.
DR AlphaFoldDB; W7G014; -.
DR SMR; W7G014; -.
DR EnsemblProtists; EUT87189; EUT87189; PFAG_02013.
DR Proteomes; UP000030666; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF71; IMPORTIN SUBUNIT ALPHA; 1.
DR Pfam; PF00514; Arm; 6.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..52
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 134..177
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 177..205
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 219..247
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 545 AA; 61158 MW; 9BD7EAA5E569C14E CRC64;
MDRRIEARRK EFKKNCDDTR RKREDLVVQI RKQQRECQLE SKRAMVMANI GFEENNTYNL
NYAKGNQNDS TNDSIYNTSS NNSSNTLEML KKIPTLAIGV RSNEYVTQLN STRELRKLLS
IEKGPPIQEV INSGVVPYIV EFLKYDDKTD LQFEAAWVIT NIASGSQEQT KVVIDNNAVP
HLVRLLSSEK EDVCEQAVWA LGNIAGDSAE CREYVLNQNS LPLLLKILRT SHKRTLIRNA
AWTLSNLCRG KPAPKFEIVS KALPTLAALI YNDDEEILTD ACWTLSYLSD GSNENINSVL
DAGVAERVVE LLSHCSFLVQ TPALRTVGNI VTGDDLQTDV VVKLGAVQKL SCLLNSSKKS
IKKEACWALS NITAGNISQI QAVIDNNVIP QLINILMKED FEVRKEAAWA ISNASSGGSE
LQIEYLVECG AIHSLSNLLD VEDANIISVT LEGLENILEM GENKKLRDNL PTNPYVHLFE
ECDSVHKIDA LQDRKVDNIC NKAWKILYKY FPFVINNELN NAQIPLNNVF ANTEDAVLNK
DFTFD
//
