ID W7G1N3_PLAFA Unreviewed; 1393 AA.
AC W7G1N3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=AMP-dependent synthetase/ligase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFAG_01421 {ECO:0000313|EMBL:EUT89271.1};
OS Plasmodium falciparum Santa Lucia.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=478859 {ECO:0000313|EMBL:EUT89271.1};
RN [1] {ECO:0000313|EMBL:EUT89271.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Santa Lucia {ECO:0000313|EMBL:EUT89271.1};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Santa Lucia.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; KE123485; EUT89271.1; -; Genomic_DNA.
DR EnsemblProtists; EUT89271; EUT89271; PFAG_01421.
DR Proteomes; UP000030666; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd05926; FACL_fum10p_like; 1.
DR CDD; cd02004; TPP_BZL_OCoD_HPCL; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR045310; Pcs60-like.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR43201; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43201:SF5; OXALATE--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
FT DOMAIN 27..443
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 665..763
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 1221..1363
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
FT REGION 1146..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1393 AA; 163949 MW; BBD3A758B7B706A1 CRC64;
MNQTNSLKSF LNIENVSDRF VTDLNTYKKQ FSYNELYEEI EKFVNFFESI NIKRGDEISI
ILFNSIEYII SFLSINFNHN ICLPQNTNLK KEEYKRYLVN NCKYIIIHDY DENNEEYSSI
KNKHSYYKNV CIYIKELAEE YGIGLIKIKK NKEKPYFTYS YINNGRKGEL PNLNNDLKNE
ENNINKEEKN MLNSDICLHL HTSGTTSKVK IVQLSNTNIK TTITNITNSY NINRDDNTII
VMPLFHVHGL IGVLLPIIYC KGNILFQLGH SFSASEFWNN VENYNITYFS AIPTILKILI
IRYEEDYLRK NKIKKNNDDD HDDDENNKCH KNPMNEKVKH KLRFIRTSSS SLDENLEKEI
EEKFEVSVFQ AYGMTEACHQ VSSNKIIISS LSSPNNLQIC KKFKSVGIPN VGVIIYNEEK
KKICDYNELG EICINGKNVM CGYKELKDND NIYIYANTVK ERNEYMMKNP FLEIAEKVPF
FKTGDIGYID QDNFLFISGR IKDIINRGGE KIIPNEIDDV LRNHDLVQDC LTFSCKDDVY
GEIINSAVIL EENKILSSYN DDYNKNNTNN IYINKSSHEQ KNMSLSPFDE NLSIYLNLKY
YMLKKELINY MKKYIADFKV PRNIYFVNNF LKTDTGKISR KKVSESIEEL KKKQIKVFDN
IIPLIFKKYD IKYIYGLYGI PINKIIYSFI KNNIYYISFR NEINASISCN YINYFDINNK
EEKNKIGILF TCSGPAFINT LSGLYNAKVN NLPMVLICFE NVRNEKLTLF EKYCNFQYFP
QLDFLNKTKE ICNQTYHVNN TLESFSTQFF NCIYTSLQHK APTYLNIDYK LIEQTITLDK
AIETLQLCDI YAQKCLNPNQ FNKYTLLNNE QENLFTQLLN KFLQIYKNNQ KCVIFMGINC
NYGYKYIIKL AELLKIPIYT NTMAKSFVKE NYLYNMNSCK SYLFNNLDSC ICIGSVFNFY
FNFGNFPNCQ KKNMLCIDLI NNAYDHDDQH HNNNNNNDNN NNNNKGDTLD VSHYFFSDLF
HILKKLYYSV KNVIHIDDIE NKKEWVNILN EMKKTNFNKM CIQINKYFEE EQFTMEQAML
IIRHILIDYY FLKNDIDEEN KKHFLNYLKH VDKIKIRDFT NMQNVQYNDL MDKELDIPDV
DEDILSDHNN DHNNDHNSGH NNNNDTHIHQ YQDYSYNVYE KKDIIPKRKK KELYFLKKQI
KNRIIITNEG SITLNLGILY LPKFGPYSYV IPQINGMMGV SMNASISAAL DNPNNIIFSI
LGDSSFGFTS NEIETICRLK LKIVFIIFNN NGIYGNRDIP REQNETNTCI KEKHQTNNPS
YYLNNPSSLY FFSKYENYVI AHGGYGCYID NRKDFIKQMK YVTSQDFDHY PALLNVIIED
SGFVNFDVDK FVK
//