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Database: UniProt
Entry: W7G1N3_PLAFA
LinkDB: W7G1N3_PLAFA
Original site: W7G1N3_PLAFA 
ID   W7G1N3_PLAFA            Unreviewed;      1393 AA.
AC   W7G1N3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=AMP-dependent synthetase/ligase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PFAG_01421 {ECO:0000313|EMBL:EUT89271.1};
OS   Plasmodium falciparum Santa Lucia.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=478859 {ECO:0000313|EMBL:EUT89271.1};
RN   [1] {ECO:0000313|EMBL:EUT89271.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Santa Lucia {ECO:0000313|EMBL:EUT89271.1};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum Santa Lucia.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; KE123485; EUT89271.1; -; Genomic_DNA.
DR   EnsemblProtists; EUT89271; EUT89271; PFAG_01421.
DR   Proteomes; UP000030666; Unassembled WGS sequence.
DR   GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd05926; FACL_fum10p_like; 1.
DR   CDD; cd02004; TPP_BZL_OCoD_HPCL; 1.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR045310; Pcs60-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR43201; ACYL-COA SYNTHETASE; 1.
DR   PANTHER; PTHR43201:SF5; OXALATE--COA LIGASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
FT   DOMAIN          27..443
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          665..763
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          1221..1363
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
FT   REGION          1146..1167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1393 AA;  163949 MW;  BBD3A758B7B706A1 CRC64;
     MNQTNSLKSF LNIENVSDRF VTDLNTYKKQ FSYNELYEEI EKFVNFFESI NIKRGDEISI
     ILFNSIEYII SFLSINFNHN ICLPQNTNLK KEEYKRYLVN NCKYIIIHDY DENNEEYSSI
     KNKHSYYKNV CIYIKELAEE YGIGLIKIKK NKEKPYFTYS YINNGRKGEL PNLNNDLKNE
     ENNINKEEKN MLNSDICLHL HTSGTTSKVK IVQLSNTNIK TTITNITNSY NINRDDNTII
     VMPLFHVHGL IGVLLPIIYC KGNILFQLGH SFSASEFWNN VENYNITYFS AIPTILKILI
     IRYEEDYLRK NKIKKNNDDD HDDDENNKCH KNPMNEKVKH KLRFIRTSSS SLDENLEKEI
     EEKFEVSVFQ AYGMTEACHQ VSSNKIIISS LSSPNNLQIC KKFKSVGIPN VGVIIYNEEK
     KKICDYNELG EICINGKNVM CGYKELKDND NIYIYANTVK ERNEYMMKNP FLEIAEKVPF
     FKTGDIGYID QDNFLFISGR IKDIINRGGE KIIPNEIDDV LRNHDLVQDC LTFSCKDDVY
     GEIINSAVIL EENKILSSYN DDYNKNNTNN IYINKSSHEQ KNMSLSPFDE NLSIYLNLKY
     YMLKKELINY MKKYIADFKV PRNIYFVNNF LKTDTGKISR KKVSESIEEL KKKQIKVFDN
     IIPLIFKKYD IKYIYGLYGI PINKIIYSFI KNNIYYISFR NEINASISCN YINYFDINNK
     EEKNKIGILF TCSGPAFINT LSGLYNAKVN NLPMVLICFE NVRNEKLTLF EKYCNFQYFP
     QLDFLNKTKE ICNQTYHVNN TLESFSTQFF NCIYTSLQHK APTYLNIDYK LIEQTITLDK
     AIETLQLCDI YAQKCLNPNQ FNKYTLLNNE QENLFTQLLN KFLQIYKNNQ KCVIFMGINC
     NYGYKYIIKL AELLKIPIYT NTMAKSFVKE NYLYNMNSCK SYLFNNLDSC ICIGSVFNFY
     FNFGNFPNCQ KKNMLCIDLI NNAYDHDDQH HNNNNNNDNN NNNNKGDTLD VSHYFFSDLF
     HILKKLYYSV KNVIHIDDIE NKKEWVNILN EMKKTNFNKM CIQINKYFEE EQFTMEQAML
     IIRHILIDYY FLKNDIDEEN KKHFLNYLKH VDKIKIRDFT NMQNVQYNDL MDKELDIPDV
     DEDILSDHNN DHNNDHNSGH NNNNDTHIHQ YQDYSYNVYE KKDIIPKRKK KELYFLKKQI
     KNRIIITNEG SITLNLGILY LPKFGPYSYV IPQINGMMGV SMNASISAAL DNPNNIIFSI
     LGDSSFGFTS NEIETICRLK LKIVFIIFNN NGIYGNRDIP REQNETNTCI KEKHQTNNPS
     YYLNNPSSLY FFSKYENYVI AHGGYGCYID NRKDFIKQMK YVTSQDFDHY PALLNVIIED
     SGFVNFDVDK FVK
//
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