ID W7IET7_9PSEU Unreviewed; 3681 AA.
AC W7IET7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Siderophore biosynthesis non-ribosomal peptide synthetase module {ECO:0000313|EMBL:EWC59380.1};
DE EC=2.7.7.- {ECO:0000313|EMBL:EWC59380.1};
GN ORFNames=UO65_5326 {ECO:0000313|EMBL:EWC59380.1};
OS Actinokineospora spheciospongiae.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=909613 {ECO:0000313|EMBL:EWC59380.1, ECO:0000313|Proteomes:UP000019277};
RN [1] {ECO:0000313|EMBL:EWC59380.1, ECO:0000313|Proteomes:UP000019277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EG49 {ECO:0000313|EMBL:EWC59380.1,
RC ECO:0000313|Proteomes:UP000019277};
RX PubMed=24604655;
RA Harjes J., Ryu T., Abdelmohsen U.R., Moitinho-Silva L., Horn H., Ravasi T.,
RA Hentschel U.;
RT "Draft Genome Sequence of the Antitrypanosomally Active Sponge-Associated
RT Bacterium Actinokineospora sp. Strain EG49.";
RL Genome Announc. 2:e00160-14(2014).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWC59380.1}.
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DR EMBL; AYXG01000206; EWC59380.1; -; Genomic_DNA.
DR RefSeq; WP_052021793.1; NZ_AYXG01000206.1.
DR STRING; 909613.UO65_5326; -.
DR PATRIC; fig|909613.9.peg.5320; -.
DR eggNOG; COG1020; Bacteria.
DR OrthoDB; 2378856at2; -.
DR Proteomes; UP000019277; Unassembled WGS sequence.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Nucleotidyltransferase {ECO:0000313|EMBL:EWC59380.1};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000019277};
KW Transferase {ECO:0000313|EMBL:EWC59380.1}.
FT DOMAIN 928..1002
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2334..2409
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3341..3416
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 995..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3681 AA; 392384 MW; 20B3D0AC147CD2A5 CRC64;
MEDLPVLAAQ ARVWFAEQAA PGSYLWGEYA DIRGDLDADV LGRAVSHAAG EAEALGVVFF
ERDGELRQRR TGLPVVVEHV DVDGEAAALR WMRGRLARPV DLETGPVYGA AILRLGPRRH
WLFQWVHHIA LDGVGMTLLS ARIARVHSDL TRGAVPPPVD HRLAPLLAEE AAYESGPDRA
WWLGVMADRP DFLSLAERPA AAQGRSTRRT STLDRAAFAD LTAAADRLGQ RWNRLVIAAA
AVHLHAVTGN RDVVLSLPVT GRTDAAGRGV PAMAANVLPL RVAVDPGATV ADLVAGVDAA
IRGVREHQRY RGERLRRDLG YADDGRKFFG PVVNIQRFDY DLRFGAATAS VHNVVAPPSE
DLSIVAYDFG DGTLRLDFDG NPANHPDALL DEVRDRFGHV LRSLAGAEPG TRVAALHLTT
PTERETLARL GIGHPSRPGG TVVTAFAAQR DRTPDAVAVR CAATGGTLTY RVLDERAAAV
AHRLLQAGTT AETLVGVLLD RSPDLVVALL GILKAGAAYL PLHRADPVRR LRAFTAGVDH
LVVDATTRAD PVATGVRHHI TVEPGPTAPD AATAPDQLAC VMVTSGSTGV PKGVAVPHDA
VARLATDRAW AEGAAERFLL HSPHAFDAVT LEVWVPLLTG GEVVVAAPGR LDVDALAEVV
TRHRVTGLWL TAGLFAAVAE ERPEVFEGLR QVWTGGDVVS PAAVRRVRGA EVVNGYGPTE
TTVFATRHRV APGASAVPIG RPIDGRRLSL LDGALRPVPP GVVGELYVGG AGLARGYRDA
PGQTATRFVA DPTGPPGARM YRTGDLARWN PDGTLDFVGR ADGQVKLRGF RVETGEVDAA
LAGLPGVGRV ATVVREDAPG RRRIVSYVVL ADGATPPDRA ALTDLLPAFM VPEEVVVLDA
LPLTRNGKLD RAALPAPGAT TAPAPAAQPG TAAEQELASL FAEVLRVPTV GVEQDFFRLG
GDSITAIQLT GRARRAGFTF GVPDLFRTPT VRALAATRTA APPREDSPEP DSPDTDDLPL
TPIMHWLRGL GGAVAGFTQS VEVSLPPEAR AALPAALRAL VAHHAMLRAR LAVTDGLWDW
HLTAEPEFRL DHHGEGADAA GLTERARAAL DPTTGPVLHA LWFDPGTLVL VVHHLAVDGV
SWRILLEDLH TALDGDPLPP VGTSFARWSR LLTRHSARAQ FRHWKALPRP AGRFPAPDPA
LDTETTRRWH PSTVPDQVTA ALDRAAEVFS CPLHHLLLTA FALAVGEGGD DPAVLLDLEG
HGREDIAGGV DTTRTVGWFT TLFPLVLDPG TTLADVEADP ARLDDAVRRV RAAVEAVPEK
GLGYGLLRHL DPQTAPVLAA RSDPAVAFNH LGRVSGLGDG AIGSSMPPDL ALGHALELNT
VITDGPRLTA NWTWAGRLLP EDTVEALAAR WVDALRLLVA RAEARATYPL TPLAQGILFH
SLHDHDGVDP YLVQFTFDLA GDLDRTRLRG ALDALLRRHP HLASGVENDE TGRPVHRVPD
NPVVEWTESA APVGRFLAED RRRRFDPGRP PLVRGALLRR GPDRHTLVLT THHLLVDGWS
MPVLVSELFT LYAGGQPPPP TPYRTFLDWL STRDTEAGDR VWRGLLAGID EPTLLAGGGR
GGGPRGEAHL DLGAAATERI GRLARERGIT TSTVLRLAFA TVLGALTGRD DVVFGATVSG
RPPELPGVER VLGLMINTLP VRCRLDPGAS AAGVLAALHA QHLSVLEHQH ADLARLPGLA
GHQELFDAVL VFENYPVDGT ALGAPGLEVT DARGLDGTHY PVTLIVVPGD SLRLRLDHRR
DVLDPTAART FLDRVAAVLD RVATDPDRPL AELDLLLPGE PRPAPPAEPA PVRESLVDLF
AAQVRAHPHA RALTCGDDHL TYAELDRRAN GLASRLIADG AGPGTLVGVS LTPSFELVVA
LLAVLKTGAA YLPLDPAHPA ERLRRITEDA GPVLTVTPET FTAAPEAGPD PGVRVDPGAP
AYVIHTSGST GTPKGVVVTH RNVVRLLAVT DRHFRHGPDD VHTLFHSFAF DVSVWELWSA
LGRGGRLVLV PRELVRSPRE FLDLLRRERV TSLSQTPSAF DQLLRAEAED PEEPTALSVR
HVVLAGEALD PTRVRRWHGP GRPLLVNMYG ITETTVHTTF HALRDPDETR GVVGEALDDL
RVHLLDHALR PVPPGCPGEV YVAGPGVALG YLGRPGLTAT RFVADPWGPP GARMYRSGDR
ARRLPDGTLE YLGRTDAQVK VRGFRIEPAE VERVLAESPD VGRAVVLPRA DALVAYVTGT
ADPAALRAHA ARVLPAHLVP AFVVPLPEIP LTVNGKVDRA ALPAPESTVR PGRAPETDAE
RLVCRVFADA LGLAAVGADD SFFDLGGHSL LATRVVNLLR DRAGADLRLR TLFDAPTPAE
LARRLTGGTE RVAFTAQVRP DRVPLSTAQR RFWFFDRFAG PNPVYNMAFA TELVGPLDAG
ALAAALRDVV DRHEVLRTTV SEVTDTDPEP HQVLGEAAAV PFTVLDSTGT GWRDLLRAEA
THCFDLVAEP PVRATLARTA PDRHVLLLLL HHIAADGWSL APLARDLSTA YAARAEGRAP
RWPDEPVQYA DYALWQRGLD LDAELAHWTA ALRGAPDAIT LPTDRTRPAQ SAHRGESVAF
HLDAGLHTAL TDLAAAHRAS PFMVVHAAIG VLLARLGAGE DIPVGTPVAG RHDSALHDAV
GCFVNTVVLR TDLSGDPTFA ELLGRVREAD LAALAHQQLP FERLVEVLNP PRSAAHHPVF
QVMLAFQDTP PPLFDLPGIT AEPVALHGGA SRLDLLWSLT PRRGGAVEGI LEYNTELFSP
AAARTLNTRL EVLLRAAVAE PHTRVGDLPL LLDGEAHRLL GGRDPVEVPA ADVPELVAEW
VTRTPDAPAV VHGDRVLSYA ELDTRARKIA AELDGVGPGD LVALCLPRDP DLIAAMLAVL
ALGAAYLPVD PDQPAARIES LLADARPRVV VGGDRAGAAD PSVLPTGTAY VLHTSGSTGA
PKGVVVPRTA LVNLLLSLRA ELSVTAEDRV LAAAPAGFDM SVPEFLLPLV TGAAAVLVDA
GTVRDPDALL DVVEERGVTV MQATPSLWQI LVARRPAALR GLRGVVGGEA VPGALVDELT
GLGVDTLACY GPTETTVWST TRRGSAPGTV PLGRPLWNTA CRVLDRRLRP VPPGVVGELH
IAGAGVATGY LHRPGQTAQR FVADPFGPPG TRMYRTGDLA SWTADGELRF HGREDDQVKL
RGHRIELGEV EAVLGAHPGV GAAAVALREH GPDDRRLVGY AVLTGTTTPD AVLAHAAAHL
PEYMVPARVV ALDRLPLTAN GKLARAALPA PDWAATRVVT PPSTLREQVL CGLFAEVLGL
PAVGATDNFF ALGGHSLLVA RLVERIGAVL GQRPRTRDVF AAGTPAGLAA ALGRPEEPAG
RFIPFRAGGT GAPVFCVHSL SGISWLYAGL LGHIDSTHPV YGIDADDSRT HTGPDSIEEL
AESYVEELLA RFPDGPYHLL GWSFGGLVSH AMAIRLRARG AEVGVSFLID PPARSGADLS
DSVDEQRVYR VLLTAVGHRD DEYPPERLTH PEVSALLRRE GSLLATFTED DVDRLVAMSR
RHARLMSGHR PAPYPGDAVY LATTGPSAVP GWVDWRPLIG GHLTEHLLDT AHHRAMQPVN
TPAVGAWLNA ALAAHRGRGN R
//
