ID W7ITU2_9PSEU Unreviewed; 498 AA.
AC W7ITU2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=FAD-linked oxidoreductase family {ECO:0000313|EMBL:EWC64340.1};
GN ORFNames=UO65_0319 {ECO:0000313|EMBL:EWC64340.1};
OS Actinokineospora spheciospongiae.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=909613 {ECO:0000313|EMBL:EWC64340.1, ECO:0000313|Proteomes:UP000019277};
RN [1] {ECO:0000313|EMBL:EWC64340.1, ECO:0000313|Proteomes:UP000019277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EG49 {ECO:0000313|EMBL:EWC64340.1,
RC ECO:0000313|Proteomes:UP000019277};
RX PubMed=24604655;
RA Harjes J., Ryu T., Abdelmohsen U.R., Moitinho-Silva L., Horn H., Ravasi T.,
RA Hentschel U.;
RT "Draft Genome Sequence of the Antitrypanosomally Active Sponge-Associated
RT Bacterium Actinokineospora sp. Strain EG49.";
RL Genome Announc. 2:e00160-14(2014).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the oxygen-dependent FAD-linked oxidoreductase
CC family. {ECO:0000256|ARBA:ARBA00005466}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWC64340.1}.
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DR EMBL; AYXG01000013; EWC64340.1; -; Genomic_DNA.
DR RefSeq; WP_035277998.1; NZ_AYXG01000013.1.
DR AlphaFoldDB; W7ITU2; -.
DR STRING; 909613.UO65_0319; -.
DR PATRIC; fig|909613.9.peg.330; -.
DR eggNOG; COG0277; Bacteria.
DR OrthoDB; 9775082at2; -.
DR Proteomes; UP000019277; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.40.462.20; -; 1.
DR InterPro; IPR012951; BBE.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR42973; BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED; 1.
DR PANTHER; PTHR42973:SF39; FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08031; BBE; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000019277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..498
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004893705"
FT DOMAIN 92..263
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT REGION 27..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 498 AA; 51452 MW; 654A6001CDEF0316 CRC64;
MSGISRRSLL RAAGVGAVAW GAAACTGAPD AQPTTSPATT VPSTTPPTTV PTTRPAPVPP
DWDALRARLD GALSLPADRG FTAAHRLYSP DFDSRTPAAV ARVATAEHVR ACVDTARDSR
LPIAARSGGH SYAGYSAPDN GLVVDLRGMA AVRVAPDGTA TVQAGARLIE VHRALAAAGR
CLPAGTCPSV GIAGLTLGGG IGVLTRKYGL TCDRLTAVRV VTADGALRTA APDSEPDLFW
ALRGGGGGNF GIATEFTFRT EPALRVTTFA TAFPAGAAPE VFAAWQEWLP GSPAELWSTV
SLSAGRRAHL SGCFIGTPAG LNPLLDAVIA RTGTKPTSRQ VVERSYLDAM LFYAGCTECS
PDSVRRQTFT ASSRVLSTPV ADPTALAALL DRTSELDLLF DSLGGAVAEV APADSAFPHR
TALATVQVFQ SGHNPGAMTA VRDGLAALGV KDGYVNYIDP TMPDWAGAYY GANLPRLATV
AARYDPDSVF AFPQAIRA
//
