GenomeNet

Database: UniProt
Entry: W7IWG6_9PSEU
LinkDB: W7IWG6_9PSEU
Original site: W7IWG6_9PSEU 
ID   W7IWG6_9PSEU            Unreviewed;       532 AA.
AC   W7IWG6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-SEP-2017, entry version 28.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=UO65_6256 {ECO:0000313|EMBL:EWC58364.1};
OS   Actinokineospora spheciospongiae.
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Actinokineospora.
OX   NCBI_TaxID=909613 {ECO:0000313|EMBL:EWC58364.1, ECO:0000313|Proteomes:UP000019277};
RN   [1] {ECO:0000313|EMBL:EWC58364.1, ECO:0000313|Proteomes:UP000019277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EG49 {ECO:0000313|EMBL:EWC58364.1,
RC   ECO:0000313|Proteomes:UP000019277};
RX   PubMed=24604655;
RA   Harjes J., Ryu T., Abdelmohsen U.R., Moitinho-Silva L., Horn H.,
RA   Ravasi T., Hentschel U.;
RT   "Draft Genome Sequence of the Antitrypanosomally Active Sponge-
RT   Associated Bacterium Actinokineospora sp. Strain EG49.";
RL   Genome Announc. 2:e00160-14(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EWC58364.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AYXG01000241; EWC58364.1; -; Genomic_DNA.
DR   EnsemblBacteria; EWC58364; EWC58364; UO65_6256.
DR   PATRIC; fig|909613.9.peg.6253; -.
DR   Proteomes; UP000019277; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019277};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019277}.
FT   DOMAIN      224    352       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      436    505       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     232    239       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   532 AA;  58560 MW;  3F7A32B80DF58D2D CRC64;
     MNLGVVWEQV VRELSAGTLS PSQRAWMRMT RPIGLLDGTA LLSAPSDFAK EAIERALREP
     ITAALSRRLG RVVSLAVKVD AAPTAPSRTA VPPPVLPPVA PPLNLDGDTI TIPAADVAAA
     AGTPVAEAPG QYTGDAAHPV LSLDDDDSEE VDETADALAT VHEIWPTFTG QPPVSGQPYT
     APAQPQTSKT RLNEKYTFDT FVIGASNRFA HAASVAVAEA PARAYNPLFI WGESGLGKTH
     LLHAVGHYAQ RLFPGMRVRY VSTEEFTNDF INSLRDDRKV AFQRRYRDID VLLVDDIQFL
     EGKEGTQEEF FHTFNTLHNA NKQIVVSSDR PPKRLETLED RLRTRFEWGL ITDIQPPELE
     TRIAILRKKA AQDRLAAPAE VLEFIAARVE ANIRELEGAL IRVTAFASLN RQPVDVTLAE
     IVLRDLIPDS QAPEISAATI MAVTAEYFGV AIDDLCGPGK TKALAQARQI SMYLCRELTD
     LSLPKIGQTF GGRDHTTVMH ADKKIRKEMA ERRRVYDQVQ ELTSRIKQRA RG
//
DBGET integrated database retrieval system