ID W7J2C6_9PSEU Unreviewed; 424 AA.
AC W7J2C6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase {ECO:0000256|ARBA:ARBA00012519};
DE EC=2.7.7.70 {ECO:0000256|ARBA:ARBA00012519};
GN ORFNames=UO65_1431 {ECO:0000313|EMBL:EWC63217.1};
OS Actinokineospora spheciospongiae.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=909613 {ECO:0000313|EMBL:EWC63217.1, ECO:0000313|Proteomes:UP000019277};
RN [1] {ECO:0000313|EMBL:EWC63217.1, ECO:0000313|Proteomes:UP000019277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EG49 {ECO:0000313|EMBL:EWC63217.1,
RC ECO:0000313|Proteomes:UP000019277};
RX PubMed=24604655;
RA Harjes J., Ryu T., Abdelmohsen U.R., Moitinho-Silva L., Horn H., Ravasi T.,
RA Hentschel U.;
RT "Draft Genome Sequence of the Antitrypanosomally Active Sponge-Associated
RT Bacterium Actinokineospora sp. Strain EG49.";
RL Genome Announc. 2:e00160-14(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-
CC D-glycero-beta-D-manno-heptose + diphosphate; Xref=Rhea:RHEA:27465,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:59967, ChEBI:CHEBI:61593; EC=2.7.7.70;
CC Evidence={ECO:0000256|ARBA:ARBA00000534};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWC63217.1}.
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DR EMBL; AYXG01000051; EWC63217.1; -; Genomic_DNA.
DR RefSeq; WP_035279877.1; NZ_AYXG01000051.1.
DR AlphaFoldDB; W7J2C6; -.
DR STRING; 909613.UO65_1431; -.
DR PATRIC; fig|909613.9.peg.1445; -.
DR eggNOG; COG0615; Bacteria.
DR eggNOG; COG2870; Bacteria.
DR OrthoDB; 9802794at2; -.
DR Proteomes; UP000019277; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0033786; F:heptose-1-phosphate adenylyltransferase activity; IEA:RHEA.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1190.20; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR011914; RfaE_dom_II.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR NCBIfam; TIGR02199; rfaE_dom_II; 1.
DR PANTHER; PTHR43793:SF2; BIFUNCTIONAL PROTEIN HLDE; 1.
DR PANTHER; PTHR43793; FAD SYNTHASE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR Pfam; PF00294; PfkB; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000019277};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EWC63217.1}.
FT DOMAIN 165..268
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
FT DOMAIN 297..391
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
SQ SEQUENCE 424 AA; 43788 MW; 0E6C831882BDF0D8 CRC64;
MKLVVVGDAL LDVDVRGAVG RLCPDAPAPV LDVSGETVRA GGAALAATLA HTDGVDVTLV
SAVADDEAGQ RLRAALGDVP AVWGPSPEPT PVKTRLRAGG TSLARLDSGG GPRPPAATDA
MLDEVLSADL VLVSDYGRGL ARDERLRAVL DRVPVVWDPH PRGPAPTPGA RLVTPNAAEA
EAFSGFSDPT EAAAELRRRW SARAVVVTLG ARGALLHGGG TPTAVPARRI PVLDPCGAGD
RFAATAAARL MAGAAPDEAV AAAVTSAADF LLREHPEAEQ PSTVDAVRAR GGTVVATGGC
FDILHAGHVR TLRAARALGD CLVVCLNSDD SVRRLKGPDR PVTTQDDRVE VLSALGCVDE
VVVFDERTPE QVLGVLRPDV WVKGGDYSAE TLPEADLVAG WGGRTVVVPY HSGRSTTGIL
TRRS
//
