ID W7J602_PLAFA Unreviewed; 941 AA.
AC W7J602;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Protein transport protein Sec24A {ECO:0008006|Google:ProtNLM};
GN ORFNames=C923_04986 {ECO:0000313|EMBL:EWC74342.1};
OS Plasmodium falciparum UGT5.1.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1237627 {ECO:0000313|EMBL:EWC74342.1, ECO:0000313|Proteomes:UP000030697};
RN [1] {ECO:0000313|EMBL:EWC74342.1, ECO:0000313|Proteomes:UP000030697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UGT5.1 {ECO:0000313|EMBL:EWC74342.1,
RC ECO:0000313|Proteomes:UP000030697};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum UGT5.1.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE124713; EWC74342.1; -; Genomic_DNA.
DR AlphaFoldDB; W7J602; -.
DR EnsemblProtists; EWC74342; EWC74342; C923_04986.
DR Proteomes; UP000030697; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR PANTHER; PTHR13803:SF39; SECRETORY 24AB, ISOFORM A; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000030697};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 224..261
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 298..574
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 583..667
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 679..765
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 796..849
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 941 AA; 106799 MW; 0B351A56E9ACA330 CRC64;
MQPYDYNRGL NNNNTANYNN QNNANAPINN PFLHNNDIGN NNNMKTNEGP YNAPTYYNPG
QHQQQQQQQQ QQGPPLHQGY QHSGVYGMNQ GNYKTNNIGE NMYNQDGHNN TSYINQGQPY
RNVTSQFIPV SSNNTLKAGG NMLGYDNMGN INHVQPIIND TYQEFLQFNA FSHFVKSSVS
YMPANTTLKQ KAYVPLGFVI QPLAPIPDGY PELASVNFGN STVVRCKKCR TYINPFVRFE
AGGKKWNCNM CYNINDTPQF YFVPLDEKGK RKDLFQRPEL CTGSVEFIAP SDYMIRPPQP
SVYLFLIDVT VTSVNSGLLD VVCSTIKSLL PKNNDSTENN NQNDNNNNNN NNNNSKNLKS
FDSRTLIGIM TFDSTIHFYN LNSNLKQTQM MVVPDIQDIF IPLPEDILVN VHECQNVIDV
LLDNLPGMWR NNKISDCCAG NALKAAFMVL KKVGGKLLFF LSSVPNIGDL TVSVNRDNKD
KSKYKNIYSS SSSGNNVVDS KLREVELLNP CNNLYAELAQ NITQYQIAVD LFACPLYNLD
LASIYPLIKN SGGSLYYYPQ FNVHQYNDKL RQELLFALTT ETAWESVMRI RISRGWKITN
WYGNYQFRGA DLLALPNCHS GQNFSIIVDL EENVVQDSIV YVQSALLYTN SNGERRIRLH
TYALPITQNI KTITDSINPQ VVVSLLAHQS IDISKKGKIA DGRNLIQNLC SQVLSSQLLQ
SECARLLSLY ILGMLKSIAF RDSGDVPPDL RIYHWYRLEN IPVESVEANF YPRMFSLHNL
EKHHGHLDEN NNIVFPDALN LTCENMTQDG CYIVEDGETI VMWIGRSINP QWIYAVFGVQ
TIDQLNTEYA ENHLGSTGNP FGVQILNIIN ALRKIRTPCY MKLLVVKQGD PLEYKFFSYL
IEDRSQHMML SLKEFLAKIC PKFPQFTPSM TTNPLATQHG R
//
