ID W7J7N3_PLAFA Unreviewed; 1560 AA.
AC W7J7N3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=C923_04348 {ECO:0000313|EMBL:EWC74977.1};
OS Plasmodium falciparum UGT5.1.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1237627 {ECO:0000313|EMBL:EWC74977.1, ECO:0000313|Proteomes:UP000030697};
RN [1] {ECO:0000313|EMBL:EWC74977.1, ECO:0000313|Proteomes:UP000030697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UGT5.1 {ECO:0000313|EMBL:EWC74977.1,
RC ECO:0000313|Proteomes:UP000030697};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum UGT5.1.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE124676; EWC74977.1; -; Genomic_DNA.
DR EnsemblProtists; EWC74977; EWC74977; C923_04348.
DR Proteomes; UP000030697; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.10.10.2130; DEAH helicase family, winged-helix domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR042035; DEAH_win-hel_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030697}.
FT DOMAIN 489..662
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 864..1048
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 20..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1188..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1226..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 282..340
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 29..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..844
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..877
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1254
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1560 AA; 182546 MW; DE541812E6FD783C CRC64;
MTKGNAILID DINTTFIKDD EEKKEMVQAN DGSSSSTPVS FNEPNKLSNK EKKKLEYQKR
IQRKKEKQLK KVQKLITKTQ SGSLSYLKNN IASSSVFNKL VDQKKEQNKN NIKNNYIENE
AIGNKNNDVN LNNNDINVKN NDLNIMNSDN INNTNDIYNN SNNKKKKKNK IKNINKNTAD
NSSESSHEEQ NGKSDLYCAL ENISKKKLIK KLKNKNKHEK EIEKKKLFKK IQEFKLNNTE
QKNLMIPFDI KAVPKNTEHL DKLLKTYEEL NIELPHYLNI IKKKIEKKRK RFLDKMEYLK
EEKNVQLTES IKSKEVDGDV KKKKNKINSL KEESESYIET NSINETYTDQ CNIIIKSESS
DEEYNKMEPH GSYDDSDMDH ENISSYHNST KEKKNDINGI NGINHINGIN HINGINGINH
INGINDINGI NGINGINNNN NNNNNNSYNN AYNKDKRKVC YKNVQVNRKE HIDKVRASLP
VLDYEQELIE AVLNYDVVFV NGDTGCGKST QVPQFLYEYG FTSNDYFIGI TQPRKIAVKS
ICNRLNDELN EEICGYQIRF EKSYFLKHSK IKVMTEGILL KEIMSDFILS KYSVIILDEA
HERSINMDII IGILSIISKI RNDNYYNFKS DIIPIKIIIM SATINDNNLF QNKIFQNFTT
VNIPTQKVQV IDHFLSYTPK DYVEEAKRKI IQIHKKLPQG SILVFLTSQE EIYRLYNMLS
NLKITNSEFN QQGENKIMDE VNFDIFDLSE GEQNKDEKVS LFFRETDENE EKKILFDVSE
EENSVESDIK ESDIKESDIK ESDYIKEGDI KESDYIKESN IEESNIDESN IEESNIEESD
IEESDVKESD VKESDNDVYD KELHDDDHMD DEPKKSNINT YELNNNTKKK SSIWKGSDGS
GTLKVFKLYS KLPMKDQMEL FHNPKENERV CILSTNIAET SLTLPNIRYV IDCGKEKRKI
YSNLNDYSYY IIDNISKCSA IQRKGRAGRI LYLLKKNKKN KKKMENEKGH VYKLYSSNYY
NYFFKNDNDY PILNYPLDSL ILYLLSFNIK NVENFPFINK PDKSKFIEAK KRLIYLNCIH
FVYKDIEFLF KQIDQKRCLK SSIENHIKKF NPYNKKGGIT LTGSFILLLP ISTRYAKILT
DVCLKSLAMK QLNTIPLAAL LVSCLYLESI FSYDYKLKMK YKKKKTTKKD KNVNMTIHQN
KEENKPKNHN NLINLFLVNK KKQKHTYTSS DDDDDDDDDD DDDDDDDDDD DNNTLSSSNN
DMSEEHIHHI KNNINVDVLE NFKEQFDNDI LFYLNICTKF YFSKDRNETC QIMHLDKKKM
NELLKLSNHL IKIINYKLNT NISLDMLQEN ISDISKNIIH YAVIQGFIDH LAIRSDLVHN
QYTRNQNITY NSKKAYITQN MNMPIYINSS SVLYQNRPYP KYILYNYITK NRNSYVMFDC
LKIDDAELGN ITNVCIFINE YEKIPPAKYD KDNDKIIVYV KPLYLPSSHY LSITYKELNE
KDLLFYNYFA LFLLDGSMFL KMTKFQMYYS HTTYDVINSA QENIKNFIEA LKNAQMNNRY
//
