ID   W7JAV1_PLAFA            Unreviewed;       608 AA.
AC   W7JAV1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Dehydrogenase E1 component domain-containing protein {ECO:0000259|Pfam:PF00676};
GN   ORFNames=C923_03436 {ECO:0000313|EMBL:EWC75905.1};
OS   Plasmodium falciparum UGT5.1.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=1237627 {ECO:0000313|EMBL:EWC75905.1, ECO:0000313|Proteomes:UP000030697};
RN   [1] {ECO:0000313|EMBL:EWC75905.1, ECO:0000313|Proteomes:UP000030697}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UGT5.1 {ECO:0000313|EMBL:EWC75905.1,
RC   ECO:0000313|Proteomes:UP000030697};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum UGT5.1.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; KE124616; EWC75905.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7JAV1; -.
DR   SMR; W7JAV1; -.
DR   EnsemblProtists; EWC75905; EWC75905; C923_03436.
DR   Proteomes; UP000030697; Unassembled WGS sequence.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030697}.
FT   DOMAIN          200..529
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
FT   REGION          130..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   608 AA;  70847 MW;  64D4D682A621A5BC CRC64;
     MLLVIWLNIF WFIPYYCFNY VLCVGNKNDM LFVKNKNLIY PYNDMNRIRR HKGVELSRKM
     VAENIQMRNM KSNNNSNNVH ENNNIDHSNN YNNNLYLSCS NKKKGKDVQS LCAIKHGNVL
     IKNINEEEKE KGIKKNDTDK LESKNDNEHK NEENNFVFSY DKKLNNYSEF NIYMENNNIE
     EYISDVNISR EEICTLYEDM YLGRLFENLV AKLYYNKRVN GFVHLYNGQE AVSTGIIKNL
     KNSDFVTSTY RDHVHALSKG VPAHKILNEL YGNYYGSTNK GKGGSMHIYS KENNFIGGFG
     FIGEQIPIAV GLAYSILYKN EFHYNPKNTS FTSTKNKNNY IQENENMIHM NNSQNVDVVV
     CFLGDGTTNI GQFFESLNLA SSYNLPIIFV IENNNWAIGM ESSRSSSDDL MNNYSKGKAF
     NIDTFKVDGN DVLTIYKLAK KKIQQIRNRT SGPIIIEAIT YRAKGHSLAD PDELRIKEEK
     TSWKKRDPIL FLSSYMKKYN LVQESYFEQV KKNTQTLLQQ AELDAEQNTK KGEHIDICNV
     IQQNIFAPSK STPYQSEYEN YKQFDDISND ELKEYYQEVL KEIQRKKEKK KLDPNDKFDQ
     KKLPLIID
//