ID W7JKE6_PLAFO Unreviewed; 833 AA.
AC W7JKE6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=U2 snRNP auxiliary factor large subunit {ECO:0000256|ARBA:ARBA00030821};
GN ORFNames=CK202_0386 {ECO:0000313|EMBL:PKC49664.1}, CYL21_2521
GN {ECO:0000313|EMBL:KAF4329344.1}, PFNF54_05805
GN {ECO:0000313|EMBL:EWC85328.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC85328.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC85328.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC85328.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PKC49664.1, ECO:0000313|Proteomes:UP000232684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:PKC49664.1};
RA Bryant J.M., Baumgarten S., Scheidig-Benatar C., Scherf A.;
RT "Plasmodium falciparum NF54 genome assembly.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF4329344.1, ECO:0000313|Proteomes:UP000754359}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:KAF4329344.1};
RA Baumgarten S., Treeck M., Scherf A.;
RT "Genome assembly of Plasmodium falciparum NF54 DiCre.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE123891; EWC85328.1; -; Genomic_DNA.
DR EMBL; QFXU01000012; KAF4329344.1; -; Genomic_DNA.
DR EMBL; NYMT01000001; PKC49664.1; -; Genomic_DNA.
DR AlphaFoldDB; W7JKE6; -.
DR SMR; W7JKE6; -.
DR EnsemblProtists; EWC85328; EWC85328; PFNF54_05805.
DR VEuPathDB; PlasmoDB:PfNF54_140072400; -.
DR OMA; WDTVDEN; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR Proteomes; UP000232684; Unassembled WGS sequence.
DR Proteomes; UP000754359; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProt.
DR CDD; cd12230; RRM1_U2AF65; 1.
DR CDD; cd12232; RRM3_U2AF65; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR006529; U2AF_lg.
DR NCBIfam; TIGR01642; U2AF_lg; 1.
DR PANTHER; PTHR23139; RNA-BINDING PROTEIN; 1.
DR PANTHER; PTHR23139:SF9; SPLICING FACTOR U2AF 65 KDA SUBUNIT; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 456..547
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 589..667
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 97428 MW; A95A92A373C50B1D CRC64;
MWKKLTSLKN SNCKSDVSNI EENDKKNVKK SDTQNEDSEK KSTGTSNGML SIKKKDTNET
DKTDEYNLDS NKKKKSFYQK KKTSNKEIEE PKDILKDDTK DVIVDDDTNI KENDNLKNEF
ISSNNKKKEK YEKDLECNEE RIHNDKKMNH CHDKEQNEKE NEDKESKQID IKEVKNSIEK
IKEKFGKNVD EKIRRNESLD KKKDAHSVKN KTGNRNSTSR SRSRNRNRSK DRYLNKRKTI
EVHSNSEENK QEKRRTKSRE RSIEYRKKSK DKWRDRSKEK SRQRSRDRSK ERSRQRSRDR
WRDRSRDRWG LDRRRSRYKD SRDRNKFSYH SRSISSDEEH YSKNKKRTKR RKSRHNIDKD
SYSSSSNSTH RRRNRKSSSS NNTRKDDNNS IQKKRKKSKW DTVDECLLNN NLLNNSVSGI
FQKSSLTVTG NLIAQNNKIT DLSRNPYEQD TDKKQRKLYI GNIPPNSKQE DVVDFFNNSI
LAVIKDSSLD VKIGDVQLMP VIKCEIFNSD SRFCFLEFRT VQITWLCLKL DSIPYNNYCL
RIGRPHDYIP PPEGDPAFTT VFTDINMDVF EKLRPSKPVN VKTSSDEENR LYIQNLPHDL
KDEQIKDLLE QFGDLKAFNI IKDLNTGLNK GYGFFEYEDS SCTQLAIHAL NGFVCGQNIL
NVKKATFNKQ PTTITTNNNM NNQNPNFIAL PNNSDVPVTL LPSSISQKIL SNSIIGLQVQ
ASRKIGEKSS KVVQLTNAVF QEDLIVDSQY EEILKEVKEE AEKYGTLQNI VIPKPNKDLS
YTEGVGKIFL HYADEATARK AQYMFNGRLF EKRVVCAAFY SEEHFLKGKY VLS
//
