ID   W7JQ36_PLAFA            Unreviewed;       776 AA.
AC   W7JQ36;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Aminopeptidase P {ECO:0008006|Google:ProtNLM};
GN   ORFNames=C923_05664 {ECO:0000313|EMBL:EWC73641.1};
OS   Plasmodium falciparum UGT5.1.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=1237627 {ECO:0000313|EMBL:EWC73641.1, ECO:0000313|Proteomes:UP000030697};
RN   [1] {ECO:0000313|EMBL:EWC73641.1, ECO:0000313|Proteomes:UP000030697}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UGT5.1 {ECO:0000313|EMBL:EWC73641.1,
RC   ECO:0000313|Proteomes:UP000030697};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum UGT5.1.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
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DR   EMBL; KE124752; EWC73641.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7JQ36; -.
DR   EnsemblProtists; EWC73641; EWC73641; C923_05664.
DR   Proteomes; UP000030697; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR   PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000590};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030697};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..776
FT                   /note="Aminopeptidase P"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004894684"
FT   DOMAIN          134..256
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          481..694
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          704..771
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   776 AA;  90053 MW;  69A33C0299022A43 CRC64;
     MQLNFLLFVF IFLMVFHLNI FNKGKRQNLV SAYLNNFKKS YFSGVTSGSD CVNKSEVSSD
     NNNNNNNNNK IAHNFFFKKY QRNFENNNLS ENQENNKNII YSGSNIFKNI YNTEMMSNNN
     TVDVNMMDNN PAARLEELRT IMKKNKIDVY ILINSDEHNS EIINEKDKKI VKITNYSGAD
     GILIVTKDKP ILYVNALYEL QAMNELDQNL FTLRISRIDN RDEIFETISS LEFNTIAFDG
     KNTSVVFYEK LRKALLNAYP KKKIVEKIIY NNNFDDVNKK DDENVLNFLV LEKSLVEIKD
     YPVNNKTLYI HDRKYNGACA GEKIDKLKQS LMYDIKNVDN LLLSELDEIA YLLNLRGYDY
     QYSPLFYSYL LFQFDREEQD FSKIVFFTTV KNLPADVKNL LEINKVIVKE YEEIVPYLRD
     VVIPSIPKHN DDNPDFKKYD ISLSPYINLM IYKLFDRKNV LLQNSPVVKM KAVKNDVEID
     NMKQAHILDG LALLQFFHWC EQKRKTKELF NETEMSLRHK VDYFRSTKKN FIFPSFSTIS
     ASGPNAAVIH YECTDKTNAT IKPAIYLLDS GGQYLHGTTD VTRTTHFGEP TAEEKRIYTL
     VLKGHLRLRK VIFASYTNSS ALDFIARENL FNNFMDYNHG TGHGVGLTLN VHEGGCSIGP
     VGGAPLKKNM VLSNEPGYYM KDKFGVRIEN MQYVISKEIT DTTEYLSFDD LTMYPYEKKL
     LDFSLLTNQE IKELNEYHTT IRNTLLPLVK QSPQEYGESV EKYLIEITEP IAIHNN
//