ID W7JWJ5_PLAFO Unreviewed; 570 AA.
AC W7JWJ5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=leucyl aminopeptidase {ECO:0000256|ARBA:ARBA00012565};
DE EC=3.4.11.1 {ECO:0000256|ARBA:ARBA00012565};
DE Flags: Fragment;
GN ORFNames=PFNF54_05753 {ECO:0000313|EMBL:EWC85449.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC85449.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC85449.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC85449.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa
CC is preferably Leu, but may be other amino acids including Pro
CC although not Arg or Lys, and Yaa may be Pro. Amino acid amides and
CC methyl esters are also readily hydrolyzed, but rates on arylamides
CC are exceedingly low.; EC=3.4.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000135};
CC -!- SIMILARITY: Belongs to the peptidase M17 family.
CC {ECO:0000256|ARBA:ARBA00009528}.
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DR EMBL; KE123887; EWC85449.1; -; Genomic_DNA.
DR AlphaFoldDB; W7JWJ5; -.
DR EnsemblProtists; EWC85449; EWC85449; PFNF54_05753.
DR OMA; LFYEYVT; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00433; Peptidase_M17; 1.
DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR HAMAP; MF_00181; Cytosol_peptidase_M17; 1.
DR InterPro; IPR011356; Leucine_aapep/pepB.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR000819; Peptidase_M17_C.
DR InterPro; IPR023042; Peptidase_M17_leu_NH2_pept.
DR PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR PANTHER; PTHR11963:SF23; ZGC:152830; 1.
DR Pfam; PF00883; Peptidase_M17; 1.
DR PRINTS; PR00481; LAMNOPPTDASE.
DR SUPFAM; SSF52949; Macro domain-like; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00631; CYTOSOL_AP; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673}.
FT DOMAIN 422..429
FT /note="Cytosol aminopeptidase"
FT /evidence="ECO:0000259|PROSITE:PS00631"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EWC85449.1"
SQ SEQUENCE 570 AA; 63527 MW; BED2C5F770A45A88 CRC64;
NNNNNIINYN KRGLKFYPFC NNLKKNINFV NINNKKGINF HSINKERKMA SEVPQVVSLD
PTSIPIEYNT PIHDIKVQVY DIKGGCNVEE GLTIFLVNNP GKENGPVKIS SKVNDKNVSE
FLKDENMEKF NVKLGTSKHF YMFNDNKNSV AVGYVGCGSV ADLSEADMKR VVLSLVTMLH
DNKLSKLTVV FEINVDKNLF RFFLETLFYE YMTDERFKST DKNVNMEYIK HLGVYINNAD
TYKEEVEKAR VYYFGTYYAS QLIAAPSNYC NPVSLSNAAV ELAQKLNLEY KILGVKELEE
LKMGAYLSVG KGSMYPNKFI HLTYKSKGDV KKKIALVGKG ITFDSGGYNL KAAPGSMIDL
MKFDMSGCAA VLGCAYCVGT LKPENVEIHF LSAVCENMVS KNSYRPGDII TASNGKTIEV
GNTDAEGRLT LADALVYAEK LGVDYIVDIA TLTGAMLYSL GTSYAGVFGN NEELINKILN
SSKTSNEPVW WLPIINEYRA TLNSKYADIN NISSSVKASS IVASLFLKEF VQNTAWAHID
IAGVSWNFKA RKPKGFGVRL LTEFVLNDAL
//
