ID W7JZ22_PLAFO Unreviewed; 780 AA.
AC W7JZ22;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=NADPH--hemoprotein reductase {ECO:0000256|ARBA:ARBA00023797};
DE EC=1.6.2.4 {ECO:0000256|ARBA:ARBA00023797};
GN ORFNames=CK202_3904 {ECO:0000313|EMBL:PKC44916.1}, CYL21_0976
GN {ECO:0000313|EMBL:KAF4330604.1}, PFNF54_05594
GN {ECO:0000313|EMBL:EWC85930.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC85930.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC85930.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC85930.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PKC44916.1, ECO:0000313|Proteomes:UP000232684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:PKC44916.1};
RA Bryant J.M., Baumgarten S., Scheidig-Benatar C., Scherf A.;
RT "Plasmodium falciparum NF54 genome assembly.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF4330604.1, ECO:0000313|Proteomes:UP000754359}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:KAF4330604.1};
RA Baumgarten S., Treeck M., Scherf A.;
RT "Genome assembly of Plasmodium falciparum NF54 DiCre.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR EMBL; KE123882; EWC85930.1; -; Genomic_DNA.
DR EMBL; QFXU01000008; KAF4330604.1; -; Genomic_DNA.
DR EMBL; NYMT01000014; PKC44916.1; -; Genomic_DNA.
DR AlphaFoldDB; W7JZ22; -.
DR SMR; W7JZ22; -.
DR EnsemblProtists; EWC85930; EWC85930; PFNF54_05594.
DR VEuPathDB; PlasmoDB:PfNF54_090028300; -.
DR OMA; YIQELWA; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR Proteomes; UP000232684; Unassembled WGS sequence.
DR Proteomes; UP000754359; Unassembled WGS sequence.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF17; NADPH--CYTOCHROME P450 REDUCTASE; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673}.
FT DOMAIN 61..204
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT REGION 408..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 92181 MW; D13A4907150E7C18 CRC64;
MFMRWNKISR YTLLSGMVVS FWLFYRSENF NLLRRLISKL RSLFPLFIKN NFLNNEIKNS
VKIYFGSQSG TAEEFAKELK ANLNDLFHIQ ANIIDLEYFN KEEIKSFGIR IFIVATYGDG
EPTDNAVEFF KWLKSLNNDN DYFRNTKYSI MGLGSKQYKH FNKIAKKLDT FLLNFKAHQI
SETIYGDDDD NIYHDFEVWK NKFFMQLPKL LNMKNIPIYV PKEDIIELTS WRDMAEIKLD
IQYYDHLIEE DNKKEKNVVT ENIINESVTN NQQLLNHNQN NLSINNKSNY ISTDIIGKFY
FNHLTGKVIS NTKLLKNVDL SNNGDKVNHI NISIEDNIIY KAADNLSILT KNTKEVITWW
LKRLNIDEKE KTKKFTFVKR NKLIDNSFTM NDPKDDVKNE TFNNDVNKGN NKTNIDYNSN
NNGNNNNNNN YNEYDDNHIY VPFPTPCSVE DALSYYCDLT TIPRLNILKK FKCFIKDIEE
LKMFNFILSN NQRNTFFNIC KECDMTFIEF VDMFMQSAVF ELSPFLQLIP RNTPKSYTIS
SSPKESKDIL SLTVKKKQYC IHSLRRALKN LKTNDMFPKL NEQKLRELCS RRWFKGSSSY
YLTEELNVND IVKFNIKPSK FVLPENIQSS HIIMIATGAG IAPFKAFLSE FIYYDQQIVK
DNFVRKGKRI LFYGCRKREV DFLYEMEIMD ALDKKHIDET YFAFSRDQES KIYVQDLILQ
KKELVWNLLQ KGAYIYVCGN SNMSKDVNKT INSLPLHFKQ NDKKFTKKLK KSGRYIYEIW
//
