ID W7JZ75_PLAFO Unreviewed; 3461 AA.
AC W7JZ75;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN ORFNames=PFNF54_05194 {ECO:0000313|EMBL:EWC85985.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC85985.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC85985.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC85985.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE123881; EWC85985.1; -; Genomic_DNA.
DR EnsemblProtists; EWC85985; EWC85985; PFNF54_05194.
DR OMA; NFCDIVG; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR CDD; cd00038; CAP_ED; 4.
DR Gene3D; 2.60.120.10; Jelly Rolls; 5.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR11635; CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN; 1.
DR PANTHER; PTHR11635:SF152; CAMP-DEPENDENT PROTEIN KINASE TYPE II REGULATORY SUBUNIT; 1.
DR Pfam; PF00027; cNMP_binding; 3.
DR SMART; SM00100; cNMP; 4.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 5.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 5.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673}.
FT DOMAIN 1941..2045
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 2235..2328
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 2375..2500
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 3092..3213
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 3219..3323
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 188..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1129..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2090..2116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2688..2748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3378..3461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 43..77
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 101..135
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1740..1767
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2626..2653
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 848..879
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1133..1149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2094..2111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2707..2748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3378..3392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3401..3461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3461 AA; 411430 MW; A009972B121A80C0 CRC64;
MEDLESKAIE NIHENLKKCI DRKIPKNTNE NEEESSKDMF FIYNSLKEYI EQLKHTNNFI
QKENDYLRKK NEELLKEFNE KNLINGNSNK SQKYGTYINE INQLNNENEF IKYKFQNMLR
KNISLERSNV ELNNQLLNKD NISQYLKSQS RIHNNKYIKD IRKKQSKSNK SLENIKGYNN
VIKMDTTTTT TTTTNNNNNN NNNNNNTDEN IRDSIKLSEN IKGINNKITN KNIHTYENIN
TYENIHTYEN NNECQNIHIK HNNVTNIQSF NFNEKFKSIC TCSMLLHDIL NILNQNIKYD
EPGIFQKSLK NIKIEKDELI MQNKLLKEKI LQIETFILRD PFLVEKLCPI HENINNNFLL
KDKNKLYQNN KNISLYRNLC YLENKNFNLR KELFHYKQKI LFYKTYVNDM RDKLKHNIIQ
LYNQYHQNKN ENTEIMTSVD ETFNTNNQQV NTYNQYNNKH ISYSKKNICD NNTKNNSLNQ
NYDFIKNQKS FFGLNNSDFN NILKTNNSKN DHNEKIIMQT STKLNELNVE KKNIEEVKDK
YLDPLEKDIP LVDLNIHNKN DMYYFEIKEL IHKRKIELDK KLKGDINVNI NTSHHNINSG
CNYVKGREED NSKNKSTLSG VIKNNILENT DNLTYINKSN NSKPEHINNY NYYINKNIMY
TYIKYKYMYD FYVQNKNILK KEMNKEEFNE FVKKYFLLYK KNNKTNQHFN NTSNDILKHY
NQSIPCVNRR NEHSINLNED KNINQKETND EDTKNDDINM NVEDYHDITL GDSHQNFIYN
IEEENIKQDL PEETCKKEDN INDYFNEKKN KYQDNIKCTS LKETGKDVHK IQENIMNKKK
RKQKEKKKIK EKEKEKEKEK EKVKKKDKDK EKEKEKEKEK EIYVNKKIYN SFDITNDTYK
NTEISKKNDE ESISKTKNEY EQYNNNENNK NTEERNHNKK HENFERFYGV EEYPRRHDSS
LEVLKKNIKD LLKKKNKDEK YAFQDDKKDI NVSEGKKDGN MQEQKVFANK YNNNKIEDNK
EKVDDKLLKE ENNIKQNSNI NKNVIESEQV KDSFNIIENV RKYEEYIDDK NDRINTHTID
EKNVISIEED NNGKQIMKQE SRELNDNEKR EDNKVNKNLI NNDNINNYSI EENKTNHNDH
NDHNGHNDHN GDNCINSFKS YIHNYNSKNE KISTEKSIII NNNDEEKYIE DKINFRNTNF
FMKSGSEYSE QDFFNNNKYS KVNIQTFKEI IYYYDINVYQ FYMNLILYSK IDLIKMYKNK
IFSVQINSAD ILQYALNTYM NFNNNTSDIE EEFIINKKDG TIKKLNEKEY KTVIEYICNN
SNNTCLKTIY HKINFITSES YEEFKNRFVE CGGVVNLINL FYDEDLNNFD KIFEVSFVNF
CDIIGISRDS CSYHFNCMDK KFKAKGYIFL RNILRYLNVE EEMKEEYHKY NFISMHLKNL
IYIYITENFH NLNEFFNAVI KQNKLYISLN EFIYFFSANE KMTKYNFAQE DVVNLYYSII
FYVYYTNKNK ILQTVNYFHK GKNINNNNDN KSINNNNDNK RINNNNIHDN NKSIMQDDEY
CFVEYDLSLC KEFFTLEDFD FAIEVKDLYF YFEGSECPLS KIKRYFIRII EIYGSVKKGI
FINDQVCNSS DDSMNSDSDI NEKDIEENTY EIFKKNKYKH IDKITLYEKK IKNTLENDNS
DDIKINKISK KTFMCLMYNI GIQIDYCLTL WGNFEPFLED HLLDYKMFSA FLNGQIKCSN
HENEENIQNI KNKINDIEED KEISHRLNHN NRLKGTICSN LFMNIEEMNN GNLLTADEIE
VTCQILNNIS PFYYLDKNER KMFIKQLKKK CYKKNYDLNL LKDHDNTNKN KQNTSNDKND
YFKNEIIILI NGILRNNKDG KCFINSVNVI YKYDIYNYIA HTNIAIINID NSIYTHEFMN
LIDKKRNISE EFMSIVNKIP ILKNFPNMKK ISLSMNVKKS MFEKNKIVIR KHDDPLQFFI
LKEGKINIFY HTSKTKNNPI NTINENQFFG EVSLIFNTLR TCDAIVESNT ACCYYISKEY
FLSLLNKDIV TEFVEYIRKT YTKGIESIIS NYVNNNEDIE QINKYRKVQN SKKNKINKNN
NNNNNNDDGN NTVTYDEDKI DEGQNLSSDE KKKTSIIYHK ENKNEQDVKK NFSNKTLNNK
LSNTSNNLST DYISLDIEYI DKNNIQSFYS DLDKLLLNIF NAEQKYFTEE IETNLRKIKS
FKKILKQMKD KETFLKNIKY EKCPKGKYII LEGDYCEYFY FIKQGQISIQ KFNQHKNMYD
EFVTYNENQY FGHQLILNNI KAFFIAVAII DTELYTLEAS LFVEFLSPFM DMLNIINDIN
QIDVLSENVK NDFQKKKQDK NYILKVLKFL KKVNIIQKLD NDTLYNASKN FTLQFFKKGQ
AIIKYQDKPD FFYIIKKGIV TVKTDFKEDT NQCVTNQKGV EEKINEEENI LTDKINKTKS
FYLYKYDYFG ELSIINEQLR TTRCEAHTNC FLLAIDKISF IKNFSILFND LLQEADIKYT
RSYSLPPWLK SMYGNNFNTN MNSLSIKIPD SASSFSSISE DSSDVFNKNQ NLYDYQTRKD
EQKDITGRNI KHINEQKEKS SNDIQIYDTN NFNNSKSIFS EYSMYSIDNE KEMKKIKEEK
EQKINEIKMK ELKVIEKIKL KEEKKIKSIM KRKVDEINMK SNSNIINSEE AYDNQGDTKN
DVIKDKPDTV TNTFATTTYN NNNNNNNNNN NNSNNNNNNN NSNNSYNILS YPNQAEKIEV
EKKKKRNSHD EWLNKNNHNV TKENKEVDIY KDNNKDSNSN IIKSEYINID NEENVENKKE
ENDKYVIDFP KKSSSILKKK ISNSNSSELD INKLLETLIR FINSEYNSIY HFYKGIDKFN
TGYVKYNDFL DYMISLNIED LFGSLENLES VFKHLCNEKN ILTLIDLYKN IYKDEEIDKY
ELNLRLTEVY GSSILAFKNI VFLNVEDALC NYINFEIVCE KVGLSNANIK SIWDEINIMN
EEYIPLEIVL SIMNGELFIE EAYIAYNLKK SLLNQVVNFF QVNENLTKMN TDMMETNFEV
IYEEPIILNK GHHKIFTNEC THIVKLLESN VYFKFLTLEQ RSFFTTLMDR KIMNYGDVLI
KQNDDEAPII CIYDGKANLI TYNLFGIEAP IGSVENNEVY GCDEAINEIP SNYEVKISSD
MATVWILERS VYKENIKPML EERQKNCTHI LPVLRNVPIL RYLSEEELVQ ISYAMKLEMY
HPNHTIIKAN TYDDKFYIIC KGLVTVEKNT EGNKDKIVLS NLKKTDYFGE LALIKNIKRT
ANVILDTEAI LLSLSDSEFK RLLHLHFDKF LNRAKANYKR VQMKKKTSIQ SEMVNLNSNT
NIHSLGSYRS KNKIVTIQDN DDDDKHKYDN TMPKLPKGNI SFTLEEKDHN NQKDDGPKVQ
PDSNKKKKDK EKYRKNKDDD KEKDKNKEKN KKIKNKKKEQ T
//
