ID W7KBY6_PLAFO Unreviewed; 2419 AA.
AC W7KBY6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=histidinol-phosphate transaminase {ECO:0000256|ARBA:ARBA00012748};
DE EC=2.6.1.9 {ECO:0000256|ARBA:ARBA00012748};
GN ORFNames=PFNF54_00664 {ECO:0000313|EMBL:EWC90500.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC90500.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC90500.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC90500.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-
CC oxopropyl phosphate + L-glutamate; Xref=Rhea:RHEA:23744,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57766,
CC ChEBI:CHEBI:57980; EC=2.6.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00001045};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; KE123739; EWC90500.1; -; Genomic_DNA.
DR EnsemblProtists; EWC90500; EWC90500; PFNF54_00664.
DR OMA; LNNMYNL; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd00615; Orn_deC_like; 1.
DR Gene3D; 3.90.105.10; Molybdopterin biosynthesis moea protein, domain 2; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000310; Orn/Lys/Arg_deCO2ase_major_dom.
DR InterPro; IPR036633; Prn/Lys/Arg_de-COase_C_sf.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR PANTHER; PTHR42885:SF2; HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; 1.
DR PANTHER; PTHR42885; HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED; 1.
DR Pfam; PF01276; OKR_DC_1; 2.
DR SUPFAM; SSF55904; Ornithine decarboxylase C-terminal domain; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673}.
FT DOMAIN 589..814
FT /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT attachment site"
FT /evidence="ECO:0000259|Pfam:PF01276"
FT DOMAIN 863..952
FT /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT attachment site"
FT /evidence="ECO:0000259|Pfam:PF01276"
FT REGION 378..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1035
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1068
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2419 AA; 281266 MW; 38EFE6E7D66136A0 CRC64;
MKLSNDPNFQ IDEDSLHMNN IDQNKIEEDV IPDSKAVSDY NVNNQEVQRK SLSLKEDEKM
RINSVGVYKV KREEYKNNMH PRNVQQKNIN QMYKQYKNIN TKVYDENIEY HRKNYEENLY
GSTKYDRIEE LENYININNV TSVCSLRIKL WEALLLYVNN LNVEFIYFII SCLKEIEVYW
GQEATENLHE IINLINDKKY KEVSNKIRET LSSLSVTTGK ITDENPFFYT LIVSSKRDEN
RSNSTNNYSD LTCELNKILQ YEHNRLSNQI NNKTLEYKII EVSNAREALL AFFINPQILS
VVIVDNLNID EERVEEKDIY NYYNDENNSV RNHSVANSYV YNSSIVNNVH MPINKSNMNN
IALNALALNN KDIYMKGMMG TSRHHNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
NNSGVNDFRK NKSYNYSNNY INNNMNLNKY NDSNKKNIIN NVNNLNNMYN LNNMYNMYNI
CNINYNNDNI CHHQFKEYKF NIADFVLGYV QLVSAPLEKM KKGFNSLVIL IKSIAYIRSS
VDIFCVCTSI TLDSLQSVNN MIIRIFTTHD DHSDLHESIL DGVKKKIKTP FFNALKAYAE
RPIGVFHALA ISKGNSVRRS RWIQSLLDFY GVNLFKAESS ATCGGLDSLL DPHGSLKDAQ
IMAARAYSSK YCFFVTNGTS SSNKIVMQAL VKPGDIILVD RACHKSHHYG FVLSQAFPCY
LDPYPVSKYG IYGAVPIYVI KKTLLEYRKS NKLHLVRLII LTNCTFDGIV YNVKRVMEEC
LSIKPDLIFL FDEAWFAYAC FHPILKFRTA MTVAEKMRST EQKRIYEKIH KKLLKKFGNV
KSLNDVPEEE LLKTRLYPNP NEYKVRVYAT QSIHKSLTSL RQGSVILISD DNFESHAYTP
FKEAYYTHMS TSPNYQILAT LDAGRAQMEL EGYGLVEKQT EAAFLIRKEL SEDPIISKYF
RILNADDLIP DRLRQCTVSY MKRKHVNNNN NKKKNNGDDD DNDDDNNNDD NNNNDDDNNN
DDDNNNDDDN NNDDDNNNNN DINHDNNHNN HNNVGNQKKY NNSLNSRCSA DEDATGSYIF
NNNIKEIEDN TESAHKIPIE YVDGKLFNVI KYPHEYMSED NSPNNIHTNL QKSNMKLLND
NNIEVGRILE SSNCFKYSHN VNMCNVLINN SSYRNNSDNK KDGSEKRYVY DEYNESVKEY
SPNDDTNYDA TYKGYVNGHV NVNMNNLMNG DNKCDWYDTN DCDDNKNIYC DKANNIYYYG
NNYKSKEEKR KKANYGSVNS ICCDSTYCMD TSDDNLSSNE CSSYIDNNNN NNNNNNNINN
NSNNNNSCSG DMKNFLEYFE RSWLSEDEFV LDPTRITLFT GYSGIDGDTF KVKWLMDKYG
IQINKTSINS VLFQTNIGTT GSSCLFLKSC LSLISQELDQ KKSLFNERDL NQFNESVYNL
VYNYIDLSVF SAFHPLFKKR YEDKNIFNNE GDLRKAFYLA YEEDYVEYIL LNNLKDRIRH
KEMIVAASFI IPYPPGFPVL VPGQIISEEI VNYLSGLSVK EIHGYDENIG FRCFYNFILD
YYETININDP YSMYQPMDKR LYEQLKEKYL HSKKDLHDHR LSNLYMYDKE TMKMKKVYIH
NNGSYSVDPY GYISDLNEEE GVIINAQHVN NKKDIFFHNK RENKIHNNNN NNNKKKTHVN
NKSDVMIIIP SEDHLNPHII HKMSDNNRKI INTKNYNNII NYTSNILNNK QDHAFYNSGS
PRTSVCSNHK NINTNGMFNN LMHKNDERGN NKSMSKHEKN NHSLYLTNGV NTKSHKKMYI
ESYNPKGDRE LDFQNKSTMY NNMDDVAYHG KHYHSVKKDI INNDTSLKEN RYNKNIMSCK
TNNNTGTNSK NERKKKKSFG IHMSLSPNNN HLKGHDTSRY SDSTSICEDN INDDNIDDTG
HKKMDAIDGH NIRNKKSDIK EILYNNNDND IYGNACDVIA CKENMYINEK DSYSDVVLIK
RNNKINKNDG NYYYHNNFSN NSKHSNVVPI LNKGNVLLNN TNVKKNDYCV IQKDNKIMSR
NNMSTKYASS NEYNKKKEEG AYYSDSSKNI HDNLFLKRKE NENIEHITKD VMKKPLIGYN
KEEIKKINEF LKINRRIADE HMGDIQIKLD EEILERKEED MYDNKNDMFN VNIKSNIEDV
ADNSPQMNID KKDIIVLASN NNYCDINNNN NNNNNCNYVK KCETNKCDIY ITKDNLEEIQ
KTNMNIKKDV EHDIGEYNFD SVINQSVNNN INILIDKYNC NNIKKLNNSN ICENNNLLSN
DNNYIVNHKV YSSIENTNTL NCNNIKTDNN SNNNNNNMPY KENKVRGLII CENDINKNTG
RQLNTLNNNS YINNLITNVD DDTFVHREGN FFLQCEFTNS DINCNMYEME TSLNNICTNL
GGVIIKNNME YDDCETKHK
//
