ID W7KCU2_PLAFO Unreviewed; 2269 AA.
AC W7KCU2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=ATP-dependent RNA helicase DHX57 {ECO:0000313|EMBL:KAF4328819.1};
GN ORFNames=CK202_3714 {ECO:0000313|EMBL:PKC45361.1}, CYL21_3028
GN {ECO:0000313|EMBL:KAF4328819.1}, PFNF54_00450
GN {ECO:0000313|EMBL:EWC90805.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC90805.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC90805.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC90805.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PKC45361.1, ECO:0000313|Proteomes:UP000232684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:PKC45361.1};
RA Bryant J.M., Baumgarten S., Scheidig-Benatar C., Scherf A.;
RT "Plasmodium falciparum NF54 genome assembly.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF4328819.1, ECO:0000313|Proteomes:UP000754359}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:KAF4328819.1};
RA Baumgarten S., Treeck M., Scherf A.;
RT "Genome assembly of Plasmodium falciparum NF54 DiCre.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE123732; EWC90805.1; -; Genomic_DNA.
DR EMBL; QFXU01000014; KAF4328819.1; -; Genomic_DNA.
DR EMBL; NYMT01000013; PKC45361.1; -; Genomic_DNA.
DR EnsemblProtists; EWC90805; EWC90805; PFNF54_00450.
DR VEuPathDB; PlasmoDB:PfNF54_030015400; -.
DR OMA; RNVFIEW; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR Proteomes; UP000232684; Unassembled WGS sequence.
DR Proteomes; UP000754359; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF234; ATP-DEPENDENT RNA HELICASE DHX40-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:KAF4328819.1};
KW Hydrolase {ECO:0000313|EMBL:KAF4328819.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673}.
FT DOMAIN 506..677
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 832..1047
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 89..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1716..1826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2003..2065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1757..1772
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1773..1824
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2028..2056
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2269 AA; 267235 MW; 4129E30B8C827C3C CRC64;
MNNTFKINKK RRTVYESYNI INIANKKRYM CNDNKMDNDN NIINEKKYFN NSSSIKNTGN
NYKNDNIDKS YDMCERRSMM DRDENIYNNN YKNKNRNNYS NKNNYSNNIN HMDNRRNTYK
GDLDGRKQYL SNKHYESKND NENSYNLKKY NFNIPPIKYN NNNNNNNNNN NNDRQNIDNN
IYKFYDDKNE KKSNKTHSYG NNFNNEFNTF NDPKQNYMSN ESHNMTQDGH PIYNHNNNNN
DGRIKNRKDI SLSSYGYNKI SNDNLSKENT SYINQYNNSG GANRHVINAQ HNNNQHNNNQ
HNNNFNYHNY KNAKPYQDKY KNGDSFKFSA YNAEQHDNMD KNYYQDIHKN NMKHSTKGDT
AISFNGQKVF GSFKNKQMKE KRKFFKNKER GSSINRPGMH NNNNNYNNNN NNNYYNNYNN
HFCDDAERRN NKNENWCEIN SNELYEKDGD MPIYNANENC NLKKMIYKND KKEKEKIKIL
LTEDNVNNVQ SNIEKLSIYK SRNEIIEMIE KNDVTFINGE TGSGKSTCVP KFLLEENIRE
NKKINIIVTE PRRIACIALS KILSELTNEK LGQKIGYRIS GESLYDSEKT VITYITIGYL
FKLFLHHKNM YKKFTHVIID EIHDRSILLD IVLLFIKLYL HNKQKDEQMF KLIIMSATMQ
SNLFYSYFEH PNIKMGSIFI GTKIFSIDTF YIEDIINYTR YGSRNIHDEK INDEKINDEK
INDEKINDEK INDDNKKSCD DKKSCDDKKS CDGNNNFVKE SVIDFILRRK NCNKINLSKN
SEMLLYKIKS EYDKNIHMFN NNNNKYCNDK NKDLDVDEII PANVFSNISN LCLELVYNLC
LKGDSVIIFL SGMQDITDMY HQLSMIINNN MDNPSNSNIN INNGNDANDA NDVNNMHNMH
NMHNMHNIAN QLTYHRTDIK IHIHMLHSCL YDNTIHKLKH NDTDINIFLS SNIAESSITI
PNVRLVIDFC IQKNIEYNDK KKAHILVKKW INKSSMEQRK GRCGRTCHGI CIRMISKNFL
NLLRDHKISE IYTHSLHLLY LYILKSMSVL NGLINKRNEV VHCDNTNVYN VKEVKDQKNG
ICKNEISHSH AENKKLTIYD VLSMIIEKPS KEKIKSTRYE LEKVKAVIKI KDKLVISIIG
QIMIRFNLSI NLCRLLLYGV LLDVTFDTII LIGILNTNDI FPNINLYSSK NIYSYAVSLE
ICSKQKAYFD GNTYSEPIML RNVFLEWLCV YLLYVQGLKK ENKFHRKELK TYYMNTCSIM
NKRNHVNSKK LLCVINSVDN LCKKMLKMLN KNSNAYKSCV YLLYLLRGGS DINYNMGNNS
NNNNDNSGEI INADGITPNN THMNEINGMN VFNVVTKYCL FDYSNQNIYL KFLFSLSFTP
LFIHGSPNLP LRDLNEGKKK SKKLMNVLNF MIDNKLDVKN CIYFSGVYIP DINILKRAIC
IMCPYLSFDI YVSKNIYYVY FHNNNYHNNY HNNILKGDDF SYYNKTICDK GDADMSVNSY
LNLTQEGHDT DGITSFGVSP LMNNNNMYGN NYIHNNVYYP CNGINNYYNN NVVNSQNNYM
MKMIMSNYYS ESFLNLTSGK NYPDIIEKIR NKLLYKYNNN VEKSIFHNFY NNILNLIQPV
NAIVPVYSNK YDEINNASIC TNIINMFSNG KWIFTMPLFN PNKRKCEVSE YFNHKYELKK
PKHLFLVKWM FLNTDNYKIK KNKQKEHVMD TNNALVNNNS LGKNVSKNDI HRDNINDYSL
NDQEDQQYNK GYYYDDYDDY DDYDDDDNND DNNDNNNNNN DDNNNNNDDD YLSNVKVESD
NNNTHQNNPD GYEGNDSSSM CSDNNKKSKQ KKMKCNLNFR SVLGFLSMCP FNFDTKRNIY
DNQTADIYAV CSSIDYSYTN DTYTWVNYVT VLPNKYFLTF FLSSIPYHDN VIIQTRTNLY
TSDILSIKIF DSKEIILKNM KKMKHKNKTN TTNYYDTNST INNPNITKHD LLRVNYLRYV
MSKLLLSLTL SFNRQEIEQN TQPLKLSEKS KRKSVIINKD GPNNDNRVDA NDKNVNGNDK
NVNDNDKNVN SQDNQGNQKD HFDDEDEEYF SDEDIMSDIE ENNILKENLY LKQIVINMIE
ENNMDYINYN KYSMDNMDID EHFNLQYLYE DEHFINLNEK WYNNKGEILM NTYDYLYNSL
KNENDYNQYN NNNNNNNNNN NNSSYMVKNI KEKALNSLEA VKSSYLNNNF SVQVQNTMNA
YERTNSEDFL FFQPINISPI KEANYKLRSM YYNEVAPTLD KFRRTNRQV
//
