ID W7KXP8_9CREN Unreviewed; 362 AA.
AC W7KXP8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Alcohol dehydrogenase zinc-binding domain-containing protein {ECO:0000313|EMBL:EWG07477.1};
DE SubName: Full=Succinate-semialdehyde dehydrogenase {ECO:0000313|EMBL:KJR79417.1};
GN ORFNames=ASUL_03174 {ECO:0000313|EMBL:EWG07477.1}, TQ35_02025
GN {ECO:0000313|EMBL:KJR79417.1};
OS Candidatus Aramenus sulfurataquae.
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Aramenus.
OX NCBI_TaxID=1326980 {ECO:0000313|EMBL:EWG07477.1, ECO:0000313|Proteomes:UP000054284};
RN [1] {ECO:0000313|EMBL:EWG07477.1, ECO:0000313|Proteomes:UP000054284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AZ1-illumnia {ECO:0000313|EMBL:EWG07477.1};
RX PubMed=24604657;
RA Servin-Garciduenas L.E., Martinez-Romero E.;
RT "Draft Genome Sequence of the Sulfolobales Archaeon AZ1, Obtained through
RT Metagenomic Analysis of a Mexican Hot Spring.";
RL Genome Announc. 2:e00164-14(2014).
RN [2] {ECO:0000313|EMBL:KJR79417.1, ECO:0000313|Proteomes:UP000053480}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AZ1-454 {ECO:0000313|EMBL:KJR79417.1};
RA Servin-Garciduenas L.E., Martinez-Romero E.;
RT "Metagenome Sequencing of an Archaeal-Dominated Microbial Community from a
RT Hot Spring at the Los Azufres Geothermal Field, Mexico.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWG07477.1}.
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DR EMBL; ASRH01000003; EWG07477.1; -; Genomic_DNA.
DR EMBL; JZWS01000008; KJR79417.1; -; Genomic_DNA.
DR AlphaFoldDB; W7KXP8; -.
DR PATRIC; fig|1326980.6.peg.623; -.
DR Proteomes; UP000053480; Unassembled WGS sequence.
DR Proteomes; UP000054284; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43350; NAD-DEPENDENT ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43350:SF2; PKS_ER DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054284};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 14..359
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 362 AA; 38204 MW; E7E14BDE837CC772 CRC64;
MKAAVLFKYN EPLKVVDNVT ISPPKAGEVK IKVVTTGLCH SDVNVFEGKT PVPPPVVAGH
EIAGIVEEVG EGVTRVKPGD RVVSAFIHPC GKCRNCASGK ENLCETFSQV RLKGTMPDGT
TRLSLDGKEV RTFLGGGFAE YAIVGENALT VVPPDIDLEK IAVLGCAGLT GYGAVNSARI
EPGETVAVVG VGGVGLSVVQ MLKASGAGRI IALGTKKWKL QRAMELGATD VVNTEEVDPV
KAVKEITNGG ADVVIEAGGN EKTVQMALDL VRIGGRVVLV GLPPANAMIP VRIASIVRNG
VTIIGNYGGR PRVDMPRLLE MVRLGKYDPT KLITGKYRLE EINEAVKLLQ QGEAIRSLIV
MK
//
