ID W7LUG5_GIBM7 Unreviewed; 1145 AA.
AC W7LUG5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=FVEG_02090 {ECO:0000313|EMBL:EWG39099.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG39099.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG39099.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7600 {ECO:0000313|EMBL:EWG39099.1}, and M3125 / FGSC 7600
RC {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [2] {ECO:0000313|EMBL:EWG39099.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=7600 {ECO:0000313|EMBL:EWG39099.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS022243; EWG39099.1; -; Genomic_DNA.
DR EMBL; DS022243; EWG39100.1; -; Genomic_DNA.
DR RefSeq; XP_018745290.1; XM_018889202.1.
DR RefSeq; XP_018745291.1; XM_018889203.1.
DR AlphaFoldDB; W7LUG5; -.
DR STRING; 334819.W7LUG5; -.
DR GeneID; 30060328; -.
DR KEGG; fvr:FVEG_02090; -.
DR VEuPathDB; FungiDB:FVEG_02090; -.
DR eggNOG; KOG0942; Eukaryota.
DR OrthoDB; 1386at2759; -.
DR Proteomes; UP000009096; Chromosome 6.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00612; IQ; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EWG39099.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009096};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 769..1145
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1113
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1145 AA; 129300 MW; 485F02ACBF9EA008 CRC64;
MFSTFTGNSR RPRNVNLSGT TGNPFTNTSW SPSAVSNTTK TVSNAQAERE KRQADREKLK
AASKIQRIWR GYKTRAELKE SQRNTFDALY KSEPRQNPSE RLPKASGLLL SFFSLRRDDD
IQRAICYAHD TDSVDLEAIA PSNVSLSRVG CLIQLLLQAL DRAIPIGDLS GDTHILFKLV
LRIITKYPDF LIPVIDSYYT VVAKLCQFQK LSEQWQDITL QAISRPLEAP SHEGTSQVYR
AYAFSFLTKN NLYFFEENIS TLSSAVRLSD LSKAIATGLS SRSSEKQSED AQLWLLAHFI
DLSRFNTNNS SGSGVLEALY AQLSGLSSTI SVRLSAKSTD SDENISEEPL MPSLDPYITA
KLMSLVDSNG ISQTLHEFST NLAGSSWQEY QSTSLLAGYI LTLLRCFPAN SDDIRMRLFL
EEIPTISGDV PTVKFLWHIM SETAVFEKLR TESEAPLNVL RRYLGVTSET SNSLEEEQDW
RIALLFLELY IFILRLSDDE DFFSGIDPRI MEQNQSISRI RSCSLSLEDV KMLTIFLKNT
AFTLHYRAQD LSKSAESLEA ASRYRFDTYF GSGQSTAMIP EEPSSPTKSP TRLDIDSLRN
IVTTAMKMLY ERDSRKRFLP TDHWLMTSKL DQSDFVSAVI AEEKRQIDED SDASDEGSEY
GDGPGIYSTI VGQRLSRHAR LEKLKAQQIR SQRERKLAEM KPKLEILKHM PFAVPFETRV
QIFRHFIQLD RLQRGEGSQP FFAGPFAKHH AQISRESLFD DAYKQFYEIG DDLKGPIQIT
FVDQFGAAEA GIDGGGVTKE FLISVATEAF SAEGGRGMFT SNEKGLLYPD PTALDVIREE
LRHAGMTEAD STFRDMISDL LRRYEFLGRI IGKCMYEGIL VDLVFAGFFL LKWTSTGPND
ENTYKGSVND LRDMDEDLYR GMLRLKNHPG DVSEMGVDFT IEDQVSDPKD SVKTVTRKLI
ANGDQIHVTN DNRLLYISYV ARHRLVVQPA PQTSAFLRGL RSIIRPSWLS MFNQSELQRL
VGGDSSEIDV EDLRKHTIYG GLYQIGDDGE EHDTIKLFWK VMHSFTDDQR RAVLKYVSST
PRAPLLGFSQ LKPLFSIRDG GTDEERLPST STCVNLLKLP RYTTEATLRE KLLYAIQSGA
GFDLS
//
