ID W7M4C6_GIBM7 Unreviewed; 899 AA.
AC W7M4C6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Peroxisomal hydratase-dehydrogenase-epimerase {ECO:0000313|EMBL:EWG42369.1};
GN ORFNames=FVEG_04199 {ECO:0000313|EMBL:EWG42369.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG42369.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG42369.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; DS022245; EWG42369.1; -; Genomic_DNA.
DR RefSeq; XP_018748560.1; XM_018891960.1.
DR AlphaFoldDB; W7M4C6; -.
DR STRING; 334819.W7M4C6; -.
DR EnsemblFungi; FVEG_04199T0; FVEG_04199T0; FVEG_04199.
DR GeneID; 30062283; -.
DR KEGG; fvr:FVEG_04199; -.
DR VEuPathDB; FungiDB:FVEG_04199; -.
DR eggNOG; KOG1206; Eukaryota.
DR HOGENOM; CLU_010194_18_0_1; -.
DR OMA; WATKVHT; -.
DR OrthoDB; 2140828at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000009096; Chromosome 2.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR CDD; cd03448; HDE_HSD; 1.
DR CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 2.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00106; adh_short; 2.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000009096}.
FT DOMAIN 774..885
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
FT REGION 761..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 899 AA; 96876 MW; 1D40D0B551B704F8 CRC64;
MADQLRYDGQ VVVVTGAGGG LGKAYATFFG SRGASVVVND LGGTSKGEGN SSKAADVVVN
EIKAAGGKAV ANYDSVENGE RIIETAISAF GRIDILINNA GILRDISFKN MKDEDWDLIY
KVHIKGSYKC ARAAWPHFRK QKYGRVINTA SAAGLFGNFG QTNYSAAKLA MVGFTETLAK
EGIKYGILAN VIAPVAASRM TETIMPPDVL ANLKPEWVVP LVAVLVHKNN TEETGGIFEV
GGGHVAKLRW ERSSGLLLKA DDSYTPGAII KNWNKVVDYS NPQYPTGPND FLTLLEESMK
MGPSEQGEKL DFTGRVALVT GGGAGIGRVY ALAFAKHGAS VVVNDLADPE PVVAEIKKLG
GKAVGVKASA EDGEKVVKAA IDAFGRIDIV INNAGILRDK AFSNMNDELW DPVLNVHLRG
TYKVTKAAWP YFLKQKYGRV LNTTSTSGIY GNFGQANYAA AKCGILGFSR ALALEGQKYG
IYVNTIAPNA GTAMTATIMP EEMVQAFKPD YIAPLVLALC SDKCPNPTGG LYEVGSGWCG
QTRWQRTGGH GFPVDVTLTP EEVLKNWKDI VTFDGRADHP SKSQDSIGKI MANLENRSKP
KESSGETNYL KVIEETLKKE GKPTEYKYEE RDVILYNLGV GAKRTDLKYV FEGSDDFQVI
PTFGVIPPFN AEMPFEFDNI VPNFSPMMLL HGEQYLEIRK FPIPTNARLV TRGRLLEVID
KGNASIARTS TTTVDANTGE DVFYNEASVF LRGAGGFGGP KRGADRGAST AANKPPARAP
DVVVESPTHD DQAAIYRLSG DYNPLHIDPA FAKVGGFKAP ILHGLCSFGI AGKAVYERFG
AFKNIKVRFA GVVIPGQTLV TEMWREGNKI IFQTKVKETG KPAIAGAAAE LRTDGKSKL
//
