ID W7M7T8_GIBM7 Unreviewed; 414 AA.
AC W7M7T8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Metacaspase-1 {ECO:0000313|EMBL:EWG43665.1};
GN ORFNames=FVEG_05041 {ECO:0000313|EMBL:EWG43665.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG43665.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG43665.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7600 {ECO:0000313|EMBL:EWG43665.1}, and M3125 / FGSC 7600
RC {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [2] {ECO:0000313|EMBL:EWG43665.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=7600 {ECO:0000313|EMBL:EWG43665.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C14B family.
CC {ECO:0000256|ARBA:ARBA00009005}.
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DR EMBL; DS022246; EWG43665.1; -; Genomic_DNA.
DR EMBL; DS022246; EWG43666.1; -; Genomic_DNA.
DR RefSeq; XP_018749856.1; XM_018893049.1.
DR RefSeq; XP_018749857.1; XM_018893050.1.
DR AlphaFoldDB; W7M7T8; -.
DR GeneID; 30063062; -.
DR KEGG; fvr:FVEG_05041; -.
DR VEuPathDB; FungiDB:FVEG_05041; -.
DR eggNOG; KOG1546; Eukaryota.
DR OrthoDB; 1077459at2759; -.
DR Proteomes; UP000009096; Chromosome 4.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.12660; -; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR PANTHER; PTHR48104:SF30; METACASPASE-1; 1.
DR PANTHER; PTHR48104; METACASPASE-4; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022807};
KW Protease {ECO:0000256|ARBA:ARBA00022807};
KW Reference proteome {ECO:0000313|Proteomes:UP000009096};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 120..405
FT /note="Peptidase C14 caspase"
FT /evidence="ECO:0000259|Pfam:PF00656"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..101
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 414 AA; 45898 MW; 7939A5356458CD1F CRC64;
MSGYPGYNSG RYGPPQPQYH QQPQGNYYPP QPSYGGGYPQ GQPSPQPPFG YQQQPPQQQY
YSGPPPQQQQ YGGHYQQGPP QPNYGSRPGG GPAPPPTAPQ QFGHGAPNSY NFRYSNCTGR
RKALLIGINY FNQRGQLRGC INDVRNMTAY LSEHFGYKRE DMVILTDDQQ NPMSQPTKQN
ILRAMHWLVK DARPNDSLFF HYSGHGGQTK DLDGDEDDGY DEVIYPVDFR QTGHITDDEM
HRIMVRPLQA GVRLTAIFDS CHSGTALDLP YIYSTQGILK EPNLAKEAGQ GLLGVISSYS
QGDLGGVASN IFGFIKKAAN GDEVRERNLR TKTSPADVIM WSGSKDDQTS ADATIASQAT
GAMSWAFVTA LKKSPQQSYV QLLNSIRDEL ATRYTQKPQL SCSHPLDTNL LFVM
//
