ID W7WXY4_TETTS Unreviewed; 471 AA.
AC W7WXY4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Histidine phosphatase family (Branch 2) protein {ECO:0000313|EMBL:EWS71715.1};
GN ORFNames=TTHERM_000756121 {ECO:0000313|EMBL:EWS71715.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EWS71715.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000032};
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR EMBL; GG662437; EWS71715.1; -; Genomic_DNA.
DR RefSeq; XP_012655756.1; XM_012800302.1.
DR AlphaFoldDB; W7WXY4; -.
DR GeneID; 24440536; -.
DR KEGG; tet:TTHERM_000756121; -.
DR InParanoid; W7WXY4; -.
DR OrthoDB; 5477542at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR033379; Acid_Pase_AS.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567:SF110; ACID PHOSPHATASE 1, ISOFORM B; 1.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..471
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004905546"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 471 AA; 55295 MW; B38249F9EA318EB0 CRC64;
MKYQLILLLL QKFLIFSSAQ FQISNSTLLK VVSVIRHGTR YVETPKLADP EDIKYSGELT
PVGMRQQNEL GRVFHKIFAE NEKLISLNYE PSEIYVQSTD KNRTIQSAQS FLHGLYQQTA
AINSKVDQKY FDPPFDSQII QNITKPDGNL SIGKDIFPIP IRTLPQDQDK YLLTHGNACN
ASIKWREQNM QSKEWQEVSN YYKPQIDLLQ QKIQEFIKSD LPTPLDINQV YEWMDAILCQ
KQKGGSNYPQ IDDELFQTMQ DISQLQFFII FFLREYQLKA ISTPFYNLLL SHLDYYIENK
TDHKLVLFFA HDTTVNMILN TLNLTGYDCI KKKLVDKNWD ETKVCFTNIV KVASNILFEL
RKSNLDNQLF ISIRYNGDYL KFNQGNDTML FSDFKTKFTD WQIKDWDVIC ENTNYYNHED
SSLQDIPTWF IAITIIVFTL FLISSYLACK FYRKLNNNSS QQKHIEFSDN L
//
