ID   W7X4E3_TETTS            Unreviewed;       791 AA.
AC   W7X4E3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Calpain family cysteine protease {ECO:0000313|EMBL:EWS74185.1};
GN   ORFNames=TTHERM_000979869 {ECO:0000313|EMBL:EWS74185.1};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EWS74185.1, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
CC   -!- SIMILARITY: Belongs to the peptidase C2 family.
CC       {ECO:0000256|ARBA:ARBA00007623}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG662689; EWS74185.1; -; Genomic_DNA.
DR   RefSeq; XP_012653277.1; XM_012797823.1.
DR   AlphaFoldDB; W7X4E3; -.
DR   GeneID; 24441285; -.
DR   KEGG; tet:TTHERM_000979869; -.
DR   InParanoid; W7X4E3; -.
DR   OrthoDB; 142935at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR022684; Calpain_cysteine_protease.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR   PANTHER; PTHR10183; CALPAIN; 1.
DR   PANTHER; PTHR10183:SF420; FAMILY CYSTEINE PROTEASE, PUTATIVE-RELATED; 1.
DR   Pfam; PF00648; Peptidase_C2; 1.
DR   PRINTS; PR00704; CALPAIN.
DR   SMART; SM00230; CysPc; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS50203; CALPAIN_CAT; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:EWS74185.1};
KW   Protease {ECO:0000313|EMBL:EWS74185.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT   DOMAIN          74..356
FT                   /note="Calpain catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50203"
SQ   SEQUENCE   791 AA;  92511 MW;  56825DDEB2386C9C CRC64;
     MDYQSYQYAY NSELGQQQDP YADRNQYNYQ QQESERDILE YLSSMGIFKK VSTLIEPPLQ
     QTEDLKKKLH VLQLRIEQNF PFTDTTFSPS ESSISDQKLN HKIEWKRLTQ LVNQDSLRFL
     IQGKPIDFIQ SSTIIEDKYV LSALNILLSK MDMIVRNFEI TQINNAGIFG IWVNQAGQWD
     LMVLDDNFPT KNNQYCMAQT NNGIWLMVLE KALAKMYGNY MGLNGGFTHN ALTDLTGAPT
     EIIDDGTEEE WFQYVDSWIK RGFLVFAEND INTRSSSVLE NSGYSFSVLA IENLGQEIIV
     KLKSPINQLV YQGQWSNQSS KWTSALRDTY DVKPIPSEDG TFWMSLSEFR NMFQYLGNLR
     THENYVYKWI NIDHTGRNQS IIKFTVEQQS HMYVILHQQD ERIATKTSPN YEYPCTRIMI
     AKVNNSQYSK TYEYVGANYQ SEREIFLEDI FQPGDYILTI EVYWVQAGDR TFTVNFYGES
     VPTVIQELDT ANLLDIQKQI IQHIALNNPM PTQKIRDYSN NGEPNIKIYN DIIAGMVYFV
     YQNRGTKKLR ERVEMAELEN LIIQKPFDNN NQYEVIISPG NEQVVVYKYN PFGEKFSFNC
     KIKAGLDPIN QSEVKASDLQ NSSSVYNGQN MFNSKGLRQS KSLKFNNNMR SSKVHQLVTR
     HDTLDENRNQ YQAKDLIQFM KVNSVPSKRM WKEQEIGVYV YNYQHPEGVV ILIQNLGEYK
     YEEKINFQLE NLRIENSQDE IAIRRFEVDY NNNSVYVMIE PGSFQMIFLD SIKKGEPYVY
     KQYSLYKYHS R
//