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Database: UniProt
Entry: W7XB07_TETTS
LinkDB: W7XB07_TETTS
Original site: W7XB07_TETTS 
ID   W7XB07_TETTS            Unreviewed;       970 AA.
AC   W7XB07;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-JUN-2017, entry version 15.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EWS73608.1};
GN   ORFNames=TTHERM_000252388 {ECO:0000313|EMBL:EWS73608.1};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EWS73608.1, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662647; EWS73608.1; -; Genomic_DNA.
DR   RefSeq; XP_012653838.1; XM_012798384.1.
DR   GeneID; 24438036; -.
DR   KEGG; tet:TTHERM_000252388; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    970       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004905824.
FT   TRANSMEM    188    208       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    316    341       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    361    380       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    392    409       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      190    423       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   970 AA;  115743 MW;  FB540EDD7824166F CRC64;
     MIFLFSILFI KLLRNINLFQ NFQQIYFIIN LKFNERFQRN QSKVLTLVSK QRRKHNIELE
     GEQSKLSWQK KWLIIMYYIS KFKTVASLTK KLFRHELLTA QQLKLIGDQT VNIEKLKQIE
     CYNFQRMMSY TKFNKIIQYK TYKWLKIKIK KYFSNFPFLL LSISTIYNKL ADYVFSSLPL
     FNYLSNFYVV WQAIIFISSF INFIYLPFEF SFNIQRGFFF QNYISLICPI IYSCDIFIKA
     NTVSFQQGSN LSMHKEIFKQ YLAGQFISDL ISLLSLNISF AQIKAFYFLF FLRFSNSFMI
     LDIFREKFFS RTYISGIISL VLLFMSSLFF AHLFACLWYY IGTQSSQGWI EFYQLDTTDI
     YSNYICSYYF AIVTMTTIGY GDITAKTTEE RLVMIFFTLT SCGIFGYIIN SIGNILADIK
     QKSDQYLTEL AKLNQYFKKY QVCLQIQANV RRYLQFKYKE GIQDQISAVQ SLNSLSQHLQ
     NQIKMDVVSR ELKQIDFLKQ ICKEETFYQL SLEVQEKIYQ PEQIILDQND IKEPSIYIIN
     YGKVLKNSQY DLSSKINEII ELKEKERFGV IEFFMNLETS KFNYKSMELT SIYSLNLSSF
     LKVIQKDNEI YEKFCFLRDQ IVFQKSLYLV KHSCESCKSL SHNLKECPCI FYKSRKLAII
     KRYKDNKFKN QQEINRKQIR TQNCLFFKKY YESESQSSNE DQNFFSSQKI LFSSVNNNTP
     NNDNQSFKPS QFFENQQTEQ NEIDKIIFDI KSPLIIQKKK LENEKQMNDD LKNIKSFQKL
     EIIEEEESKN SIQILGLQQQ NFVKNNHMSI TSILENNSKN DQICVLQAIY KNIKEIFKIL
     QDENGFSQFQ KKVVSQQQTN SSHYIKLENQ LPSQKQLKMP QLHDASLVNA ARINFQNQLQ
     NKQHKIISEH CCEELEKMQK FKIFYPKFNY DIVIEKFNSI TQLQNIPLNL RRLKQQKKQI
     NENKRMRTLK
//
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