ID W7XI08_TETTS Unreviewed; 1532 AA.
AC W7XI08;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Transmembrane protein, putative {ECO:0000313|EMBL:EWS72874.1};
GN ORFNames=TTHERM_000933398 {ECO:0000313|EMBL:EWS72874.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EWS72874.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG662564; EWS72874.1; -; Genomic_DNA.
DR RefSeq; XP_012654602.1; XM_012799148.1.
DR STRING; 312017.W7XI08; -.
DR GeneID; 24441137; -.
DR KEGG; tet:TTHERM_000933398; -.
DR InParanoid; W7XI08; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR10877:SF183; AT14535P-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 814..832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..948
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1005..1025
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1045..1066
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1103..1124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1156..1179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1191..1218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 964..1130
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 1532 AA; 181289 MW; B151406143C7305D CRC64;
MQPHRSLQNQ ENILAQKPRG DEIECNIQES NNQIYRNMKT IRRENINIDN HNSQKNEKQE
IEQQKEYKIA KELLGIQDEK VDENKKKYNI EMQYLIPIFM FGLSQYTLNE NQNASNIQEK
AFKKQEEFNN FENDLTQNNQ NPTKEQQNQD ELIDNIGLNG KFIGIKQKLS QHQEANQNQI
KREDINNLIV EQEVQNLDQN TKSQAMNENL QHKIGQIEDF AKKYGNLLDQ GASSNMELIQ
QMCEKGISDL KVLGTIYLML ICLLTQFNMN QLAQNLYFKF QKDIMQVQND SQMFDMDIYS
FIEKNINSVI YLNELIILAL RFQEFIPLLN IFLLVFQVRI HIIRDQIISA MSKKSLSSLE
IIIGNYKKRV PKKKSKRIAG NQKIKKAMEQ VTSYYVQKGS IENEHELLLF IISEGFHQIS
VELLMYFVET KLIPPQLFIT KKVIKQSLIN MNIAMFSKAF LFRQKWVKSL FLTEKIFLHI
CQLIRCNETF AEGLYLMKKI SQKKQRSSAP LWYTENIIEL FEEVAQKQSQ FYMLQIYTLN
PVISAIIISK ILYKLSLNKN PLQIQLSRLS DHFKNLAIQF RDQITDERQM KMTLFKIIFP
SDKSLVQICK SKIIYTYYNE FLQQDLVLKL LFEKYESSNH YDMNLLSSST SFNYLFNFKK
IKVPYLHYQQ KFEKIETNIK QPSAPLIKFN INQNDLDQVQ EDKQFFGHLL QQKVKSNQQE
ILKLKSLNNN QDPNELIKQY KAAFQKKEFN NKQPSEKYEK KKKSSQNIQF NTKRTLNIFK
EIVPISFKYV SKLNHFYQYN IYIKSLKIRS YLEMILYFAI FNYSLSTFFQ ILDLSNVYLQ
LNPEFVNLLF NCPSKSLQAE IAVAMQTYVP RFTIEEIQQY QSTNLSLFCS MLIELTTGNI
QKYMNDWQDD CVLFVGKNQQ VTTIVDNFNR SIYFIYLIPV GFILKVIHSQ IIQRRYKYDI
TEYIDIFLVY LCIQHYFINS NIEKIQNSQD CNYLSYSSIS NNLQALVYVL TLILVCLFGK
VIQFLSRNEK LGILIKIINL TFRQVFSVLF IFSLDILAFA SLLYLLSSYR LDIYDSFANS
IRTLIATTLG TFDYNNMDLA ESIIQTVFLF TSNVIMINLL IAILTTTYSQ ITQRSSVEYA
LILFEEYFIG KFDKNYSLLI AFPPPFNLFQ LLFSWVLFFQ KLVNINQVFQ MIGYTLLLLI
VYAVFISINV ILVPLAWFKM IFTIIKHEYQ SMILNLVLIK KQFNIQNSCF QSKAYCIISQ
TLVLIFKLLQ WIIFGLPYLL FHAIFTDSII FIKSAYSSNN NKYKYNKNLL NSPLPQRCYY
LLKCQPQIID YRFKSESNIQ HFQLFQNYLK FKFLLNAAEN ERKNIDGKPQ KLLQNYFLKV
VKNLLRRKNL MNKFNKEFNQ EYQNRQHALS DTIQNEHTDP SFLAIMRTKQ IYLSTEFWQK
KKVTTLRQQN FYNLAINPSI KHTLEVQQSL IKKVQSQNQH ISQIRSIQNQ MSNIQGVQHS
NQNSFNKIPN TINKQQTQRQ KLHTLYEQIE VE
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