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Database: UniProt
Entry: W7XI46_TETTS
LinkDB: W7XI46_TETTS
Original site: W7XI46_TETTS 
ID   W7XI46_TETTS            Unreviewed;       743 AA.
AC   W7XI46;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-JUN-2017, entry version 18.
DE   SubName: Full=Cation channel family protein {ECO:0000313|EMBL:EWS72989.1};
GN   ORFNames=TTHERM_001250061 {ECO:0000313|EMBL:EWS72989.1};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EWS72989.1, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662600; EWS72989.1; -; Genomic_DNA.
DR   RefSeq; XP_012654473.1; XM_012799019.1.
DR   GeneID; 24442015; -.
DR   KEGG; tet:TTHERM_001250061; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    180    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    314    334       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    365    384       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    396    416       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      502    600       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   743 AA;  88213 MW;  5FD0AE30910BF1A6 CRC64;
     MKSNMIGVKS KAQIVPLDNS EIKNLREEVI RTKIIDGGSN QQKQFLLQEQ NQKPSQMDLQ
     QLNVLKEQEG QHLEQIPNQI NQISQLHALR FVYINRFAQK IKQYSSYYRF TQTKKRFLQI
     IGDYAFDYDV YFYQRIFKHD QPSRLQIIIK NIEAWLERQI TTLDQKSGAI MLPSSSVNTI
     WNLVQFIFVL IYIIYLPIRL AFDSLHRQKG YFTVLEVSPN IIQIINMFFE LNTGFYRHGQ
     IILDRWEICS NYFKSRFIFD FVINICWLIS LNPDISVWVK CFGLLRLFTL FRLLKELDQA
     NFLKEKYGNI FELLKLSGCI FLFAHLACCC WYALAVYEDD IGIQNTWLKK DIQNYELDLN
     LNLKLQGYVA GIYYCIVTMT TIGFGDISPI TYRERIFTLI FCILSCFLFA FTMGSIGEIV
     KQFSLKGEEF KQKMEMLNHY MKKRNLSQNL QVRVRKYYEN QNQESSEDNE CGSKLIDNLT
     PELREDVQKD IYSFLFKNIS FFQINFSERL IQNIYRIVEE KQFQIDEKIF EEGQKSDKLY
     VIIKGQVQLL LQNRHSIVTK REGEVLGFAE FFSQQPFQFS AKASRNTQVA VIKYDDFIKL
     TSENQHDNVI YIFNFYNQIL NECICFLFWK RKYNSKSKIL FCLIMNYALF KVLFVKVVVR
     LTTSFKIAKQ QFTIKSIRRT QFSRTSESKQ LDRSGSEGHR ATKRLLIDNL QKQEHQSKQK
     ILNKKKKLTM IFFILNSQQI IYL
//
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