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Database: UniProt
Entry: W7XKP9_TETTS
LinkDB: W7XKP9_TETTS
Original site: W7XKP9_TETTS 
ID   W7XKP9_TETTS            Unreviewed;      1525 AA.
AC   W7XKP9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-OCT-2017, entry version 25.
DE   SubName: Full=Cyclic nucleotide-binding domain protein {ECO:0000313|EMBL:EWS75104.1};
GN   ORFNames=TTHERM_000295529 {ECO:0000313|EMBL:EWS75104.1};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EWS75104.1, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M.,
RA   Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E.,
RA   Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K.,
RA   Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C.,
RA   Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M.,
RA   Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C.,
RA   Barbeau R.A., Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila,
RT   a model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662740; EWS75104.1; -; Genomic_DNA.
DR   RefSeq; XP_012652342.1; XM_012796888.1.
DR   GeneID; 24438256; -.
DR   KEGG; tet:TTHERM_000295529; -.
DR   KO; K21867; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009168};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    194    214       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    226    245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    331    354       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    374    394       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    406    423       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      534    609       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   1525 AA;  178976 MW;  93FFCEBFA1DF300E CRC64;
     MEETVVQKES FLSKFARKRK VSPIGDEQKN NQNDNLIYTS TADDQNNSQL KLTLKKRTFL
     ISSIQPTIKA KDIFMKALKR KKELDNEEKQ KSKNVIKMSI VYIEKFIRLM RQQSSLIRFK
     ETRLSQLEII NDKSVESQYF LVNKLLTKEK PSLLLLTYEY LQKMQIYIWM KSHIVSRLKL
     DQVDYLFLPN SQLYMMWSIF LMIVLTLNVV YIPLAISFQD IQLSTFASIL INILPNVSFM
     VEIIIKFNTA IYKKGLIIKS RKQIVLSYLQ KRFWYDLCIV FCFFFGSYFQ NAFIQIVLLL
     RFFDITRLIA EIEERYNLKE RLYGINDMVK LILLILYIAH LCGCIWHYIA VIEIENGFSQ
     TWMNKSGISL SDSWWYRYVD SLYWAVVTMC TLGYGDIVPI TSNEKVFTIW VTLISCFVFG
     YSINQIGEIL QEFLRIEEEF KIKMSKLNMY MQKRELNDDV CVKVRKYFEY LHKENLQSNN
     EGATVIDSLE SDLKQEVLRD IYGKLLNSKK LFSLNFSIDK LAVKIKEKKV GLHEYIYKEG
     EEAEEVYFLV KGQAEVIKTQ TKTVLQSIQK GMMFGEIEFF TGQQRQFSLR ASTVCQLAYL
     NKQEFLDTIK GNNVEFERFN KMKDLLSIYK DTQGFDHQCG SCGKYTHLIV ECPQINICIN
     KYKTLSKYNF YVCQVRDNKF KRNRAKYIGT FQKTALVQQQ AKIFYENEKL QFLDIYDGDE
     DDAILNQNNQ LNRSPYGDKR KSWNQVMEQN VRKKSQVRLD ASQNQEELGI REKKKTIIGY
     QKIPRSSFSK KDQVKKLSRI ENIQQDRHDQ MKQDELPNNQ MKADNNFLKV INEKFYKQTD
     ETENNKNEIP QVRKSMKQQE QEFNKLIQLE KEKQTNVVQD EKNDLIGVDK QIVNEQESLF
     QIKKRGLMPS FFDSKKFSQP KKNEFQSFQS SNQNSPQLEF QKIENKQNIN GSEQRLRNKS
     SLTLSQDTSS DEFSSEEQAD IQNNEAKNFN KKKQSKKSSK NEIKSKKSSK SKNSQHTINR
     QSDNYNPNQI QKALMLIGKS SQDDQKLLNQ QESVQQKYLN SLTIAQQLIV NGSFQQIDET
     YLQNQINSQN NSINSQSSKK LSTKIFSMSQ ERKSQIKPDT LDPQQINHPS HSSKDIISKK
     KSINQISQQI LSNFDTENLP NQITPSIIVQ PPISERITTQ VSSQKQKTSQ ENIFKKLSIQ
     QIKKQSKSSI KDKSLTQLFE DTKNDNNSNI ADQQSLTQHN ITNNQKLFQN VITQAKAVQD
     VRRKVSILVK KNGPQDTPIN VTLSVNQQEQ EQLREILEIE QNMAKGSRLK KTMARKLNSK
     LRSRSNELLE ILDNKKFTKK PTGNNKITQN QDQENHSQGY IFDIPSLNNL DSTYYQFQMN
     KRISNSQLSQ HQIKYNSDED NQEEVQFVNF IDELELRKFE QIFLKKYDDE FASCFEKGKQ
     YQEYFPKNNI SNVLEMISIR RKLNPFYRVL LLRKKAQSSK KRPLNRKNNR KSKLNINLIN
     KSMYGTSFLK QSYSVNSQAH SQVSK
//
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