ID   W7Y0C8_9BACT            Unreviewed;       807 AA.
AC   W7Y0C8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=Pyruvate dehydrogenase E1 component subunit beta {ECO:0000313|EMBL:GAF01397.1};
GN   ORFNames=JCM21142_3 {ECO:0000313|EMBL:GAF01397.1};
OS   Saccharicrinis fermentans DSM 9555 = JCM 21142.
OC   Bacteria; Bacteroidota; Bacteroidia; Marinilabiliales; Marinilabiliaceae;
OC   Saccharicrinis.
OX   NCBI_TaxID=869213 {ECO:0000313|EMBL:GAF01397.1, ECO:0000313|Proteomes:UP000019402};
RN   [1] {ECO:0000313|EMBL:GAF01397.1, ECO:0000313|Proteomes:UP000019402}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 21142 {ECO:0000313|EMBL:GAF01397.1,
RC   ECO:0000313|Proteomes:UP000019402};
RA   Starns D., Oshima K., Suda W., Iino T., Yuki M., Inoue J., Kitamura K.,
RA   Iida T., Darby A., Hattori M., Ohkuma M.;
RT   "Draft Genome Sequence of Cytophaga fermentans JCM 21142T, a Facultative
RT   Anaerobe Isolated from Marine Mud.";
RL   Genome Announc. 2:e00206-14(2014).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAF01397.1}.
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DR   EMBL; BAMD01000001; GAF01397.1; -; Genomic_DNA.
DR   RefSeq; WP_044211719.1; NZ_KI912107.1.
DR   AlphaFoldDB; W7Y0C8; -.
DR   STRING; 869213.GCA_000517085_04411; -.
DR   eggNOG; COG0022; Bacteria.
DR   eggNOG; COG1071; Bacteria.
DR   OrthoDB; 9769337at2; -.
DR   Proteomes; UP000019402; Unassembled WGS sequence.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:GAF01397.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019402}.
FT   DOMAIN          472..646
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
FT   COILED          323..353
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   807 AA;  90501 MW;  0CC58B9005BD4DCF CRC64;
     MISNSGISFD EFKKEVLRDY RVGHMSRNMS ITGRKEVLSG KAKFGIFGDG KEIAQIAMAK
     QFKKGDWRAG YYRDQTFMLA AGMTTPVEFF ASLYGETNTE RNPDNGGRSF NNHFGTRTIT
     DTGEWKNIVD IKCTSSDISP TAGQMPRLIG LAYASKLYRS NPGLKQAKIF SRGGNEVAFG
     TIGDASTSEG HFFETMNAAA VHQIPVAMSV WDDGFGISVP KKIQTTKESI SELLKGFEKG
     ARDTTGIVIY KLKGWDYAGM CQAYEEGVAR CRKEHVPVLF HVEEVTQPVG HSTSGSHERY
     KTEERLQWEK DFDCLVKMRE WIIERSLATA KELDELEKDA RQEVQEAKKE AWKQYTTTLK
     EERDALLNLV ENRTCECSGK KNERIDAMAN GLRNELTLNR KAILSTARKI LRHICNSCNH
     TGSLKNNLQD WIRDYRSKAH EMYNDRLYCE DEFAALKVPV VPPLYPKEIE SVPGREILRD
     NFDALFAKVP ELVTFGEDTG VLGGVNQSME GLQKKYGSSR IWDEGIRETT IIGTGLGMAL
     RGFRPIAEIQ YFDYLMYGLQ TMSDDLATLR YRTKGGQKAP MIVRTRGHRL EGIWHSGSPT
     SMVINSIRGV YVCVPRDMTR AAGMYNTLVQ ADDPALVIEP LNGYRIREPK PSNIGEYNIP
     LGIPEVLHVG QDATLVTYGS CVRIAQEAVQ QLGEIGISVE LIDVQTLLPF DIHGVILESV
     KKTNRVVFFD EDVPGGTTAY MMQQVIEKGG GFNYLDSAPR TVTAKDHRPA FGTDGDYFSN
     PSAEDVYEAI YDMMSEVNPQ KFPPIYS
//