ID W8BDF1_CERCA Unreviewed; 1079 AA.
AC W8BDF1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Toll-like receptor 1 {ECO:0000313|EMBL:JAB99325.1};
DE Flags: Fragment;
GN Name=TLR1 {ECO:0000313|EMBL:JAB99325.1};
OS Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Tephritoidea;
OC Tephritidae; Ceratitis; Ceratitis.
OX NCBI_TaxID=7213 {ECO:0000313|EMBL:JAB99325.1};
RN [1] {ECO:0000313|EMBL:JAB99325.1}
RP NUCLEOTIDE SEQUENCE.
RA Geib S.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB99325.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24495485; DOI=10.1186/1471-2164-15-98;
RA Calla B., Hall B., Hou S., Geib S.M.;
RT "A genomic perspective to assessing quality of mass-reared SIT flies used
RT in Mediterranean fruit fly (Ceratitis capitata) eradication in
RT California.";
RL BMC Genomics 15:98-98(2014).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; GAMC01007230; JAB99325.1; -; mRNA.
DR AlphaFoldDB; W8BDF1; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF550; TOLL-9, ISOFORM A; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:JAB99325.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 863..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 922..1067
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 19..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:JAB99325.1"
SQ SEQUENCE 1079 AA; 123345 MW; 869C459DDA4E1898 CRC64;
TTTTTTINDW HIQLPLQVIN GSNNDNNDHN NDTNSNNAEL PLDQTKLLCD NDGKYASNRC
DRGRNIHNNK PEPYDSDEPK NSNSQHGGTE KSKVENENTN SNNNGDNLTI DFISVAQAAA
TAQTSTTKII QSAESTQNET KTLQNYYQYN LTVNGNDKQE RDASNITTIF DETIIVTTPP
ALEFQPTESD AVEEIPDEII DPGNPLETPI VPSTPHDVLD GLDSLLGAQD LEKYLLQYKT
ELNNNCLMDG MKDIFQWWSY SNGTLNTNGY ESKKAETYSL NSYYMDFSYQ NLTDDENLHR
LALEKKLRIG RSVYVFSAAH NNLTQIPFLT LSTINGTLQY LTLKGNDFKA HSEDCENIES
KRPPQNFPPT HFNEDDIYEN DMENYIENDI NAAHERTGYF RHLLEPKRPQ EADPDAKGIA
WATFPKLPYL MELDISNCHI ENIAQEAFRN ITGIRKLFMS RNKMNTIPQD AFNLLSQLEY
LDLAYTNLLD FDYQLPHPTL AAAVNLIYGV KIQSSAFRKL KKLKYLDMSH TQITRTSAMA
FAHLGSSLEY MSLCYTSFPL IGNALFKKTR LIGLDLSGNP YTSFVDDAFE SIADTLQYLF
FEGSNIKELG WLKHLVNARV LGLARNNINM LSSEYFVSLK NLEAIDLSAN NIGNWYSRVF
TNNTLLRALN LRNNNINILN SEMLEDFKQL DYLGIGENNF ICDCSLSDLV EVAAINNKKA
ECSKTSTLDD VPQLVYDNLE DLSRFFMPTI MARTLLRNLK RSFENLGIYN KARYLPRMRL
AASIGYSKLR TAFEQTDECE VIDLPNNDAL LNGTAPKFQL IDYEFDHYWC FNGTNRMQLV
QLDCQGKAFD VDIAESLNEL TKIVVASICS IMGLTLLLVI IYLKRWHIYY YYSSLKSAAL
LSVAAKDQVK KFNELAESDP SMVYDIFISY CQSDRDWVLE ELLPNVEESG NISICLHERD
FQIGVAILEN IISCMDRSRA LMLIVSSNFL LSHWCQFEMH LAQHRIFEVS KEHLIIVFLE
DIPRSKRPKT LQYLMEVKTY IKWPGAKGRE VKPEERKYFW KRLRRSLEHL GITPTESQA
//
