ID W8BLC5_CERCA Unreviewed; 348 AA.
AC W8BLC5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 03-MAY-2023, entry version 26.
DE SubName: Full=Gamma-aminobutyric acid receptor alpha-like {ECO:0000313|EMBL:JAB99587.1};
DE Flags: Fragment;
GN Name=GBRAL {ECO:0000313|EMBL:JAB99587.1};
OS Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Tephritoidea;
OC Tephritidae; Ceratitis; Ceratitis.
OX NCBI_TaxID=7213 {ECO:0000313|EMBL:JAB99587.1};
RN [1] {ECO:0000313|EMBL:JAB99587.1}
RP NUCLEOTIDE SEQUENCE.
RA Geib S.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB99587.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24495485; DOI=10.1186/1471-2164-15-98;
RA Calla B., Hall B., Hou S., Geib S.M.;
RT "A genomic perspective to assessing quality of mass-reared SIT flies used
RT in Mediterranean fruit fly (Ceratitis capitata) eradication in
RT California.";
RL BMC Genomics 15:98-98(2014).
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DR EMBL; GAMC01006968; JAB99587.1; -; mRNA.
DR AlphaFoldDB; W8BLC5; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProt.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:UniProt.
DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR CDD; cd19049; LGIC_TM_anion; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR001390; GABAAa_rcpt.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR PANTHER; PTHR18945:SF835; GAMMA-AMINOBUTYRIC ACID RECEPTOR ALPHA-LIKE; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR01079; GABAARALPHA.
DR PRINTS; PR00253; GABAARECEPTR.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
PE 2: Evidence at transcript level;
KW Ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Ion transport {ECO:0000256|ARBA:ARBA00023286};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:JAB99587.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023286}.
FT TRANSMEM 58..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..144
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT REGION 262..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:JAB99587.1"
SQ SEQUENCE 348 AA; 38665 MW; D8A48365A3FA46E4 CRC64;
VGGASGAGYD GRGGGGFGVA YGGISIDASG SVRFESSRAS EYSMLMVNFH LQRHMGNFLI
QVYGPCCLLV VLSWVSFWLN REATADRVSL GITTVLTMTF LGLEARTDLP KVPYLTALDF
FVFLSFAFIF ATILQFAVVH YFTKYGSGEC YFIIEEMDSD TESEADARTL KSDFNVSTES
KLYEVIPLSM CSIPIHGAGK GSASASSSGI GVGIGTRTRR NSATKRRILS GGSRYSFSCF
GWPCFRRRKR GRVGFDISDE DDEEAHLRAG EEPTPHRGSG KRRMSFYRRE ELEARRKGKR
VPQYNSVSKI DRASRIVFPM LFLVINVFYW YGYLSRSSRI LANTPSTT
//
