ID W8BP88_CERCA Unreviewed; 1018 AA.
AC W8BP88;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Metabotropic glutamate receptor {ECO:0000313|EMBL:JAC00728.1};
GN Name=GRM {ECO:0000313|EMBL:JAC00728.1};
OS Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Tephritoidea;
OC Tephritidae; Ceratitis; Ceratitis.
OX NCBI_TaxID=7213 {ECO:0000313|EMBL:JAC00728.1};
RN [1] {ECO:0000313|EMBL:JAC00728.1}
RP NUCLEOTIDE SEQUENCE.
RA Geib S.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAC00728.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24495485; DOI=10.1186/1471-2164-15-98;
RA Calla B., Hall B., Hou S., Geib S.M.;
RT "A genomic perspective to assessing quality of mass-reared SIT flies used
RT in Mediterranean fruit fly (Ceratitis capitata) eradication in
RT California.";
RL BMC Genomics 15:98-98(2014).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; GAMC01005828; JAC00728.1; -; mRNA.
DR AlphaFoldDB; W8BP88; -.
DR EnsemblMetazoa; XM_023303137.1; XP_023158905.1; LOC111591679.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15934; 7tmC_mGluRs_group2_3; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF158; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:JAC00728.1};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 738..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 852..872
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 902..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..953
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 959..980
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 739..1003
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 1018 AA; 114696 MW; 1A4703849C050CB3 CRC64;
MLLWVKSKII SSAQKLHLYS IREIFHILII LSIEIQILCG AERKETASFT YMDTAEVPII
LKDIQSKCSA EFVTTTTTDK NQINSNNNFR STIYTGYEEG KRIINKSDSS INTKFVRLTS
TPSSQDMISV ILPGDIILGG LFPVHEKGEG VPCGPKVYNR GVHRLEAMLY AIDRVNDDST
LLPDITLGVH ILDTCSRDTY ALNQSLQFVR SSLNNLDASA FECTDASVPH LRKNASSGPV
FGVIGGSYSS VSLQVANLLR LFHIPQISPA STAKTLSDKT RFDLFARTVP PDTFQSIALV
DIIKCLNWSY VSTIHSEGSY GEYGIEAFHK EASERNLCIA ASEKVPSAAD DKIFDSIIAK
LQKKPSARGV VLFTRAEDAR RVLLAAKRAN LSHPFHWIAS DGWGKQQKLL VGLEDIAEGA
ITVELQSEII EDFDRYMTQL TPLTNTRNPW FEEYWEDTFN CVLSKNYIPS NLQKHDISMQ
KTKRLASNHN NDFKLYASST INNHSRLCDE SLRLSDKVGY EQESKTQFVI DAVYAFAHAL
HKLHKDLCLP RSNQNDEITS GSAKRLHRHN PSAWYRKPLD SESHACPEMA NYDGKDFYNN
YLLNVSFIDL TGSVVKFDRQ GDGLARYDIL NYQRLENSTG YQYKVVGKWF KELELNIADV
VWNKEYDLPT SACSLPCELG MIKKQQGDTC CWICDNCEPY EYVLNEFTCK DCGPGYWPYS
DKLSCYALEV KYIRWQSLFA LIPLAIASLG IIMTVAVIAL FAQNHDTPLV RASGRELSYT
LLFGILFCYC NTFALIAKPT IISCVLQRFG IGVGFSIIYS ALLTKTNRIS RIFHSASKSA
QRLKYISPQS QVVITVSLIA VQVLITMIWM IVEPPGTRFY YPDRTEVILK CKIQDMSFLF
SQLYNMILIM ICTIYAIKTR KIPENFNESK FIGFTMYTTC IIWLAFVPIY FGTGNSHEIQ
ITTLCISISL SASVALICLY SPKVYILVFH PDKNVRKLTM NSAVYRRSAV ALAGGTMG
//
