ID W8C5W1_CERCA Unreviewed; 529 AA.
AC W8C5W1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Bifunctional polynucleotide phosphatase/kinase {ECO:0000313|EMBL:JAC01907.1};
GN Name=PNKP {ECO:0000313|EMBL:JAC01907.1};
OS Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Tephritoidea;
OC Tephritidae; Ceratitis; Ceratitis.
OX NCBI_TaxID=7213 {ECO:0000313|EMBL:JAC01907.1};
RN [1] {ECO:0000313|EMBL:JAC01907.1}
RP NUCLEOTIDE SEQUENCE.
RA Geib S.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAC01907.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24495485; DOI=10.1186/1471-2164-15-98;
RA Calla B., Hall B., Hou S., Geib S.M.;
RT "A genomic perspective to assessing quality of mass-reared SIT flies used
RT in Mediterranean fruit fly (Ceratitis capitata) eradication in
RT California.";
RL BMC Genomics 15:98-98(2014).
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DR EMBL; GAMC01004649; JAC01907.1; -; mRNA.
DR RefSeq; XP_012155047.1; XM_012299657.1.
DR AlphaFoldDB; W8C5W1; -.
DR EnsemblMetazoa; XM_012299657.2; XP_012155047.1; LOC101457540.
DR GeneID; 101457540; -.
DR KEGG; ccat:101457540; -.
DR OrthoDB; 5490169at2759; -.
DR GO; GO:0046404; F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0046403; F:polynucleotide 3'-phosphatase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd22671; FHA_APTX-like; 1.
DR CDD; cd01625; HAD_PNP; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR041388; FHA_2.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006549; HAD-SF_hydro_IIIA.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013954; PNK3P.
DR InterPro; IPR006550; PNKP.
DR InterPro; IPR006551; Polynucleotide_phosphatase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR NCBIfam; TIGR01664; DNA-3'-Pase; 1.
DR NCBIfam; TIGR01662; HAD-SF-IIIA; 1.
DR NCBIfam; TIGR01663; PNK-3'Pase; 1.
DR PANTHER; PTHR12083; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE; 1.
DR PANTHER; PTHR12083:SF9; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF17913; FHA_2; 1.
DR Pfam; PF08645; PNK3P; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
PE 2: Evidence at transcript level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Kinase {ECO:0000313|EMBL:JAC01907.1};
KW Transferase {ECO:0000313|EMBL:JAC01907.1}.
FT DOMAIN 24..92
FT /note="PNK FHA"
FT /evidence="ECO:0000259|Pfam:PF17913"
SQ SEQUENCE 529 AA; 59450 MW; 4C2805FD8B3B317D CRC64;
MFAAMSVAKA FNRSTGSKRT TRTCILKPFS SECTSINLCP GKQIIGRSLD TGIEDVRCSK
RQLELDVDLE SPHIKLRVIG MNPCSVNGMM LMQESKCKLE HGDVIELVYG KHQYELQFQP
PPKDIKSETK NEGNVSQIEN TIGSGRWESS ENGAMIVYTD DAVKASDKIA GYDVDGTIIT
TKSGNVFPKH TDDWQILYAE VPKKLKLLHE SGYKICFFTN QGGIGSGKIK LDDFKRKTKD
ILKKVGVPIQ VFIAIEDGQY RKPLTGMWKH LVEHKNDNIG IDLGKSFYVG DAAGRPESGS
GKTKRRKDHS LADRRFAANI GVSFYTPEEH FLNRPTEQYL KPDYQPSEVV TNMNIIPLLE
PDNVKLPADN SEMIIMVGLP GSGKSFFCKQ HLEKHDYVIA NADKLGTTQS CLKICEKALA
AGKSCVVDNT NVDVESRKKF LALAKQYNVS CRCFVMNVQL DLVRHNIKYR HLTDTNHSKI
NEMVFNMMKK KYTAPTVGEG FTHIIKVNLK PSFQSKADEE LYKLYLLEK
//
