ID W8CQ03_9EURY Unreviewed; 391 AA.
AC W8CQ03;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 22-FEB-2023, entry version 15.
DE SubName: Full=2-ketoisovalerate ferredoxin oxidoreductase subunit alpha {ECO:0000313|EMBL:AGM16431.1};
DE EC=1.2.7.7 {ECO:0000313|EMBL:AGM16431.1};
GN Name=vorA {ECO:0000313|EMBL:AGM16431.1};
OS Thermococcus guaymasensis.
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=110164 {ECO:0000313|EMBL:AGM16431.1};
RN [1] {ECO:0000313|EMBL:AGM16431.1}
RP NUCLEOTIDE SEQUENCE.
RA Eram S.M., Ma K.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGM16431.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24982594; DOI=10.1155/2014/349379;
RA Eram M.S., Oduaran E., Ma K.;
RT "The Bifunctional Pyruvate Decarboxylase/Pyruvate Ferredoxin Oxidoreductase
RT from Thermococcus guaymasensis.";
RL Archaea 2014:349379-349379(2014).
CC -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma
CC chain. {ECO:0000256|ARBA:ARBA00011595}.
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DR EMBL; KC262637; AGM16431.1; -; Genomic_DNA.
DR AlphaFoldDB; W8CQ03; -.
DR GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity; IEA:UniProtKB-EC.
DR GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR033412; PFOR_II.
DR InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR PANTHER; PTHR32154; PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR PANTHER; PTHR32154:SF0; PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR Pfam; PF17147; PFOR_II; 1.
DR Pfam; PF01855; POR_N; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:AGM16431.1}.
FT DOMAIN 15..237
FT /note="Pyruvate flavodoxin/ferredoxin oxidoreductase
FT pyrimidine binding"
FT /evidence="ECO:0000259|Pfam:PF01855"
FT DOMAIN 261..364
FT /note="Pyruvate:ferredoxin oxidoreductase core"
FT /evidence="ECO:0000259|Pfam:PF17147"
SQ SEQUENCE 391 AA; 43648 MW; 75EFE81FD75A782B CRC64;
MPKKVVSGNY AAAYAVKHAR VEVVAAYPIT PQTSIIEKIA EFIANGEVEN LQYVPVESEH
SAMAACIGAS AAGARAFTAT SAQGLALMHE MLHWASGARL PIVMVDVNRA MAPPWSVWDD
QTDSLAQRDT GWMQFYAENN QEVYDGVLMA FKIAETVNLP AMIVESAFIL SHTYDVVEMI
PQELVDEFLP PRKPLYDLAD FSRPFSVGAL GTPADYYEFR YKIAKAMEDA KKVIKDVGKE
FGERFGRDYS DMIEKGYVDD ADFVFMGMGS LMGTVKEAVE LLRKEGYKVG SPKVRWFRPF
PKEELREIAE SVKGIAVLDR NFSFGQEGIL FNEAKGALYN TSARPIMKNY IVGLGGRDFT
VPDVKKVAEN MKAIIEKGEL DVEVDWYHLK R
//
