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Database: UniProt
Entry: W8CY34_RABIT
LinkDB: W8CY34_RABIT
Original site: W8CY34_RABIT 
ID   W8CY34_RABIT            Unreviewed;       905 AA.
AC   W8CY34;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   SubName: Full=Toll like receptor 3 {ECO:0000313|EMBL:AGU70409.1};
GN   Name=TLR3 {ECO:0000313|EMBL:AGU70409.1};
OS   Oryctolagus cuniculus algirus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=230741 {ECO:0000313|EMBL:AGU70409.1};
RN   [1] {ECO:0000313|EMBL:AGU70409.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mertola25 {ECO:0000313|EMBL:AGU70393.1}, Mertola26
RC   {ECO:0000313|EMBL:AGU70396.1}, Mertola29
RC   {ECO:0000313|EMBL:AGU70400.1}, Mertola31
RC   {ECO:0000313|EMBL:AGU70403.1}, Mertola34
RC   {ECO:0000313|EMBL:AGU70407.1}, Mertola35
RC   {ECO:0000313|EMBL:AGU70409.1}, Mertola36
RC   {ECO:0000313|EMBL:AGU70411.1}, Pancas11 {ECO:0000313|EMBL:AGU70387.1},
RC   Pancas20 {ECO:0000313|EMBL:AGU70391.1}, Pancas3
RC   {ECO:0000313|EMBL:AGU70376.1}, Pancas7 {ECO:0000313|EMBL:AGU70381.1},
RC   and Pancas8 {ECO:0000313|EMBL:AGU70384.1};
RX   PubMed=23964588; DOI=10.1186/1471-2156-14-73;
RA   Abrantes J., Areal H., Esteves P.J.;
RT   "Insights into the European rabbit (Oryctolagus cuniculus) innate immune
RT   system: genetic diversity of the toll-like receptor 3 (TLR3) in wild
RT   populations and domestic breeds.";
RL   BMC Genet. 14:73-73(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   EMBL; KC963184; AGU70376.1; -; Genomic_DNA.
DR   EMBL; KC963189; AGU70381.1; -; Genomic_DNA.
DR   EMBL; KC963192; AGU70384.1; -; Genomic_DNA.
DR   EMBL; KC963195; AGU70387.1; -; Genomic_DNA.
DR   EMBL; KC963199; AGU70391.1; -; Genomic_DNA.
DR   EMBL; KC963201; AGU70393.1; -; Genomic_DNA.
DR   EMBL; KC963204; AGU70396.1; -; Genomic_DNA.
DR   EMBL; KC963208; AGU70400.1; -; Genomic_DNA.
DR   EMBL; KC963211; AGU70403.1; -; Genomic_DNA.
DR   EMBL; KC963212; AGU70404.1; -; Genomic_DNA.
DR   EMBL; KC963215; AGU70407.1; -; Genomic_DNA.
DR   EMBL; KC963217; AGU70409.1; -; Genomic_DNA.
DR   EMBL; KC963219; AGU70411.1; -; Genomic_DNA.
DR   AlphaFoldDB; W8CY34; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0001819; P:positive regulation of cytokine production; IEA:UniProt.
DR   GO; GO:0032680; P:regulation of tumor necrosis factor production; IEA:UniProt.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR041015; TLR3_TMD.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   PANTHER; PTHR24365:SF524; TOLL-LIKE RECEPTOR 3; 1.
DR   Pfam; PF13855; LRR_8; 6.
DR   Pfam; PF01582; TIR; 1.
DR   Pfam; PF17968; Tlr3_TMD; 1.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00365; LRR_SD22; 11.
DR   SMART; SM00369; LRR_TYP; 15.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 6.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AGU70409.1};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..905
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007737249"
FT   TRANSMEM        705..726
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          755..898
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   905 AA;  104057 MW;  493726DB876A84EF CRC64;
     MSQSVPYHIS SLWGLLSLWM LCTSSGNKCT VRQEVADCSH LKLTQIPDDL PTNITVLNLT
     HNQIKRLPPA NFTRYSRLTV LDGGFNTISK LEPELCQSLP SLKVLNLQHN ELSQLSDKTF
     VFCMNLTELH LMSNSIQKIQ NNPFKNQKNL IKLDLSHNGL KSTKLGTQLQ LQNLQELLLS
     KNKIQALKSE ELAFLGNSSL KKLELSSNLI KEFSPGCFHA IGQLFGLFLN NAQLGPSLIE
     KLCLELSNTS IQNLSLSNSQ LNRISNRTLL GLKHTNLTML DLSHNNLNMI DDDSFVWLPH
     LKYLFLEYNN IVHLSNHSFY GLFNVRHLNL KRSFPKQSVS LTSLPKIDDF SFQWLRCLEY
     LNMEDNDIPS IKRNMFTGLI NLRYLSLSNS FTNLRTLKNE TFSSLAHSPL LILNLTKNKI
     SKIESDAFSW LGSLEVLDIG INEIGQELTG QEWRGLENIF EIYLSYNKYL QLTSNSFALV
     PSLQRLMLRR VALKNVDISP SPFHPLHDLT ILDLSNNNLA NINEEMLEGL EKLEVLDLQH
     NNLARLWKQA NPGGPVHFLK GLSHLHTLNL ESNGFDEIPE GVFKNLFQLK SINLALNNLN
     VLPQSVFDDQ VSLKSLNLQK NLITSVEKKV FGPVFKNLSN LDMSFNPFDC TCESIAWFVN
     WINKTRTNIS ELSSHYLCNT PPQYHGFSVR LFDTSSCKDS APFELLFMIN TSFLLLFIFI
     VLLIHFEGWR ISFYWNVSVH RILGFKEIDG QPEQFEYTAY IIHAYKDRDW VWEHFSSMEE
     EDPSIKFCLE ERDFQAGVLG LEAIVNSIKR SRKIIFVITQ HLLKDPLCKR FKVHHAVQQA
     IEQNLDSIIL IFLENIPDYK LNHALCLRRG MFKSRCIFYW PVHKERIEAF HHKLQVALGS
     RNSLH
//
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