ID W8GFR7_9MOLU Unreviewed; 550 AA.
AC W8GFR7;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=arginine--tRNA ligase {ECO:0000256|ARBA:ARBA00012837};
DE EC=6.1.1.19 {ECO:0000256|ARBA:ARBA00012837};
GN Name=argS {ECO:0000313|EMBL:AHK22629.1};
GN ORFNames=X271_00529 {ECO:0000313|EMBL:AHK22629.1};
OS Candidatus Hepatoplasma crinochetorum Av.
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Hepatoplasma.
OX NCBI_TaxID=1427984 {ECO:0000313|EMBL:AHK22629.1, ECO:0000313|Proteomes:UP000019450};
RN [1] {ECO:0000313|EMBL:AHK22629.1, ECO:0000313|Proteomes:UP000019450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Av {ECO:0000313|EMBL:AHK22629.1,
RC ECO:0000313|Proteomes:UP000019450};
RX PubMed=24482531; DOI=10.1093/gbe/evu020;
RA Leclercq S., Dittmer J., Bouchon D., Cordaux R.;
RT "Phylogenomics of "Candidatus Hepatoplasma crinochetorum," a Lineage of
RT Mollicutes Associated with Noninsect Arthropods.";
RL Genome Biol. Evol. 6:407-415(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-
CC tRNA(Arg); Xref=Rhea:RHEA:20301, Rhea:RHEA-COMP:9658, Rhea:RHEA-
CC COMP:9673, ChEBI:CHEBI:30616, ChEBI:CHEBI:32682, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78513, ChEBI:CHEBI:456215;
CC EC=6.1.1.19; Evidence={ECO:0000256|ARBA:ARBA00001766};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363038}.
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DR EMBL; CP006932; AHK22629.1; -; Genomic_DNA.
DR AlphaFoldDB; W8GFR7; -.
DR STRING; 1427984.X271_00529; -.
DR KEGG; hcr:X271_00529; -.
DR PATRIC; fig|1427984.3.peg.508; -.
DR eggNOG; COG0018; Bacteria.
DR HOGENOM; CLU_006406_0_1_14; -.
DR OrthoDB; 9805987at2; -.
DR Proteomes; UP000019450; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00671; ArgRS_core; 1.
DR Gene3D; 3.30.1360.70; Arginyl tRNA synthetase N-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR001278; Arg-tRNA-ligase.
DR InterPro; IPR005148; Arg-tRNA-synth_N.
DR InterPro; IPR036695; Arg-tRNA-synth_N_sf.
DR InterPro; IPR035684; ArgRS_core.
DR InterPro; IPR008909; DALR_anticod-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00456; argS; 1.
DR PANTHER; PTHR11956:SF5; ARGININE--TRNA LIGASE, CYTOPLASMIC-RELATED; 1.
DR PANTHER; PTHR11956; ARGINYL-TRNA SYNTHETASE; 1.
DR Pfam; PF03485; Arg_tRNA_synt_N; 1.
DR Pfam; PF05746; DALR_1; 1.
DR Pfam; PF00750; tRNA-synt_1d; 1.
DR PRINTS; PR01038; TRNASYNTHARG.
DR SMART; SM01016; Arg_tRNA_synt_N; 1.
DR SMART; SM00836; DALR_1; 1.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF55190; Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363038};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363038};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363038};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363038};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363038};
KW Reference proteome {ECO:0000313|Proteomes:UP000019450}.
FT DOMAIN 3..86
FT /note="Arginyl tRNA synthetase N-terminal"
FT /evidence="ECO:0000259|SMART:SM01016"
FT DOMAIN 430..550
FT /note="DALR anticodon binding"
FT /evidence="ECO:0000259|SMART:SM00836"
SQ SEQUENCE 550 AA; 64256 MW; FAC20BCBE506DBBB CRC64;
MKDKIILYLK KYLDLNKFSH FTEKIIILNS KSKNFGDFNT NLAIIIAKKN NKDPLIIANE
IKEYLLKVSL FKDITITKPG FINFFINEKE IIKYALSYFD KNYHDKFNTL QKLKINYEFV
SANPTGYLHL GHARHAIIGE TTVMILKYVG HDVIREYYIN DAGVQIDNLA HSIYNHALIK
LNIKKSDQDN SQYNGYEIID YASYLAKNHQ DLFIDKNKEQ AIIKIKKLAV DHFLEEIKKD
LKALNVANYD IFTSDKKLIE DKKVDKILAK FQKSKYYYKK DDAIWIKTSA FGDPKDRVLI
KKDLTYTYMV ADFANHVKKY QGGYDLMIDL WGADHHGYEA RIKAGLEILG YDSNKLKIDY
ITLVKLLENG QEFKMSKRKG TAIRIREILD LIDVPAFKFS ILAKAKSQMH SIDIAKVNKK
DINNNIYWYI QYANSRINQL LNKVEAKTIA NLKLKNDYFY LGKEQAEQNL LLKIIAFADQ
ILQAANNREP LILINYLKEL AQAFHAYYNS CKIINKNKEI EEERLLLIIS LKNLFERIFN
ILKIEPIKKM
//
