ID W8QEP4_9PSED Unreviewed; 359 AA.
AC W8QEP4;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=D-malate dehydrogenase (decarboxylating) {ECO:0000256|ARBA:ARBA00013126};
DE EC=1.1.1.83 {ECO:0000256|ARBA:ARBA00013126};
GN ORFNames=CD58_18165 {ECO:0000313|EMBL:AHL34705.1};
OS Pseudomonas brassicacearum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=930166 {ECO:0000313|EMBL:AHL34705.1, ECO:0000313|Proteomes:UP000019521};
RN [1] {ECO:0000313|EMBL:AHL34705.1, ECO:0000313|Proteomes:UP000019521}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DF41 {ECO:0000313|EMBL:AHL34705.1,
RC ECO:0000313|Proteomes:UP000019521};
RX PubMed=24812222;
RA Loewen P.C., Switala J., Fernando W.G., de Kievit T.;
RT "Genome Sequence of Pseudomonas brassicacearum DF41.";
RL Genome Announc. 2:e00390-14(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-malate + NAD(+) = CO2 + NADH + pyruvate;
CC Xref=Rhea:RHEA:18365, ChEBI:CHEBI:15361, ChEBI:CHEBI:15588,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.83;
CC Evidence={ECO:0000256|ARBA:ARBA00001361};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; CP007410; AHL34705.1; -; Genomic_DNA.
DR RefSeq; WP_025214295.1; NZ_CP007410.1.
DR AlphaFoldDB; W8QEP4; -.
DR KEGG; pbc:CD58_18165; -.
DR PATRIC; fig|930166.5.peg.3539; -.
DR eggNOG; COG0473; Bacteria.
DR OrthoDB; 9767905at2; -.
DR Proteomes; UP000019521; Chromosome.
DR GO; GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR InterPro; IPR011829; TTC_DH.
DR NCBIfam; TIGR02089; TTC; 1.
DR PANTHER; PTHR43275; D-MALATE DEHYDROGENASE [DECARBOXYLATING]; 1.
DR PANTHER; PTHR43275:SF1; D-MALATE DEHYDROGENASE [DECARBOXYLATING]; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Manganese {ECO:0000256|ARBA:ARBA00023211}.
FT DOMAIN 7..355
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 359 AA; 39315 MW; 8309B5342E747A5A CRC64;
MSRTQYKIAV IPGDGIGKEV MPEGVRVLDA VAARFNLELQ WDWFDFASAD YYLAHGKMMP
DDWFDTLKGY DAIYFGAVGW PDVVPDHISL WDSLLQFRRE FDQYVNLRPC RLMPGVKAPL
ANRKPGDIDF WVVRENTEGE YSSVGGKMFP GTDREIVLQE TVMTRVGVDR ILKFAYDLAQ
SRPKKHLTSA TKSNGIAITM PYWDERVAEM GNKYPDVNVD KYHIDILTAN FVLHPDWFDV
VVASNLFGDI LSDLGPACTG TIGIAPSANI NPERNFPSLF EPVHGSAPDI AGKGIANPIG
QIWCGAMMLE HLGHPEAGAA VLTAIESVLA MGPENAPLTA DIGGTGNTES LGKAIAAAV
//
