ID W8QQK7_HBV Unreviewed; 176 AA.
AC W8QQK7;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=External core antigen {ECO:0000256|RuleBase:RU361253};
DE Flags: Fragment;
GN Name=C {ECO:0000256|RuleBase:RU361253, ECO:0000313|EMBL:AHL69157.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AHL69157.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AHL69157.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=N12 {ECO:0000313|EMBL:AHL69157.1};
RX PubMed=23925707; DOI=10.1002/jmv.23695;
RA Mayaphi S.H., Martin D.J., Mphahlele M.J., Blackard J.T., Bowyer S.M.;
RT "Variability of the preC/C region of hepatitis B virus genotype A from a
RT South African cohort predominantly infected with HIV.";
RL J. Med. Virol. 85:1883-1892(2013).
CC -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC acting as a T-cell tolerogen, by having an immunoregulatory effect
CC which prevents destruction of infected cells by cytotoxic T-cells.
CC {ECO:0000256|RuleBase:RU361253}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361253}.
CC -!- PTM: Cleaved by host furin. {ECO:0000256|RuleBase:RU361253}.
CC -!- PTM: Phosphorylated. {ECO:0000256|RuleBase:RU361253}.
CC -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC {ECO:0000256|RuleBase:RU361253}.
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DR EMBL; KF985214; AHL69157.1; -; Genomic_DNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.4090.10; Viral capsid, core domain supefamily, Hepatitis B virus; 1.
DR InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR InterPro; IPR002006; Hepatitis_core.
DR InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR Pfam; PF08290; Hep_core_N; 1.
DR Pfam; PF00906; Hepatitis_core; 2.
DR SUPFAM; SSF47852; Hepatitis B viral capsid (hbcag); 1.
PE 3: Inferred from homology;
KW Host-virus interaction {ECO:0000256|RuleBase:RU361253};
KW Viral immunoevasion {ECO:0000256|RuleBase:RU361253}.
FT DOMAIN 1..27
FT /note="Hepatitis B virus capsid N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08290"
FT NON_TER 176
FT /evidence="ECO:0000313|EMBL:AHL69157.1"
SQ SEQUENCE 176 AA; 19852 MW; ED79B9ED0F72FAE9 CRC64;
MQLFHLCLII SCSCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPS DFFPSVRDLL
DTASALFRDA LESPEHCSPH HTALRQAILC WGELMTLATW VGTNLEDPAS RDLVVSYVNT
NMGLKFRQLL WFHISCLTFG RETVLEYLVS FGVWIRTPPA YRPPNAPILS TLPETT
//