ID   W8RT85_9RHOB            Unreviewed;       367 AA.
AC   W8RT85;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=4-hydroxyphenylpyruvate dioxygenase {ECO:0000313|EMBL:AHM04368.1};
DE            EC=1.13.11.27 {ECO:0000313|EMBL:AHM04368.1};
GN   ORFNames=roselon_02015 {ECO:0000313|EMBL:AHM04368.1};
OS   Roseibacterium elongatum DSM 19469.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Roseibacterium.
OX   NCBI_TaxID=1294273 {ECO:0000313|EMBL:AHM04368.1, ECO:0000313|Proteomes:UP000019593};
RN   [1] {ECO:0000313|EMBL:AHM04368.1, ECO:0000313|Proteomes:UP000019593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19469 {ECO:0000313|Proteomes:UP000019593};
RA   Fiebig A., Goeker M., Klenk H.-P.P.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009283-1};
CC       Note=Binds 1 Fe cation per subunit. {ECO:0000256|PIRSR:PIRSR009283-1};
CC   -!- SIMILARITY: Belongs to the 4HPPD family.
CC       {ECO:0000256|ARBA:ARBA00005877}.
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DR   EMBL; CP004372; AHM04368.1; -; Genomic_DNA.
DR   RefSeq; WP_025312166.1; NZ_CP004372.1.
DR   AlphaFoldDB; W8RT85; -.
DR   STRING; 1294273.roselon_02015; -.
DR   KEGG; red:roselon_02015; -.
DR   PATRIC; fig|1294273.3.peg.1987; -.
DR   eggNOG; COG3185; Bacteria.
DR   HOGENOM; CLU_034004_1_0_5; -.
DR   OrthoDB; 9780241at2; -.
DR   Proteomes; UP000019593; Chromosome.
DR   GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR   CDD; cd07250; HPPD_C_like; 1.
DR   CDD; cd08342; HPPD_N_like; 1.
DR   Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 2.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR041735; 4OHPhenylPyrv_dOase_C.
DR   InterPro; IPR041736; 4OHPhenylPyrv_dOase_N.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR   InterPro; IPR037523; VOC.
DR   NCBIfam; TIGR01263; 4HPPD; 1.
DR   PANTHER; PTHR11959; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; 1.
DR   PANTHER; PTHR11959:SF1; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   Pfam; PF14696; Glyoxalase_5; 1.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   SUPFAM; SSF54593; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; 1.
DR   PROSITE; PS51819; VOC; 2.
PE   3: Inferred from homology;
KW   Dioxygenase {ECO:0000313|EMBL:AHM04368.1};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR009283-1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR009283-1};
KW   Oxidoreductase {ECO:0000313|EMBL:AHM04368.1};
KW   Pyruvate {ECO:0000313|EMBL:AHM04368.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019593};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          23..154
FT                   /note="VOC"
FT                   /evidence="ECO:0000259|PROSITE:PS51819"
FT   DOMAIN          164..320
FT                   /note="VOC"
FT                   /evidence="ECO:0000259|PROSITE:PS51819"
FT   BINDING         167
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR009283-1"
FT   BINDING         245
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR009283-1"
FT   BINDING         329
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR009283-1"
SQ   SEQUENCE   367 AA;  40921 MW;  32365662DC4185AD CRC64;
     MGPFPHDAPR ASITAENPAG TDGFEFVEFA HPDPQVLRDL FASMGYTHTA THKTKAVELW
     QQGDITYILN AEPGSFAARF VAEHGPCAPS MGWRVADARH AFAHAVAKGA EPYEGPDKTL
     DWPAIKGIGG SLIYFTDQYW DSSPYNAEFD WISDAHPEGV GFYYLDHLTH NVFKGNMDTW
     FRFYGDLFNF REIRFFDIEG KYTGLFSRAL TSPCGRIRIP INEDRGETGQ IVNYLKKYNG
     EGIQHIAVGA RDIYAATDAI AARGIRFMPG PPDTYYDRSF DRVKGHDEPV DRMKRHGILI
     DGEGVVDGGE TRILLQIFSK TVIGPIFFEF IQRKGDDGFG EGNFKALFES IEAEEAANGD
     YGDVAAE
//