ID W8W3N8_SALSA Unreviewed; 972 AA.
AC W8W3N8;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=TLR19 protein {ECO:0000313|EMBL:CDH93609.2};
DE SubName: Full=Toll-like receptor 12 {ECO:0000313|RefSeq:XP_014004717.1};
GN Name=TLR {ECO:0000313|EMBL:CDH93609.2};
GN Synonyms=LOC106573839 {ECO:0000313|RefSeq:XP_014004717.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:CDH93609.2};
RN [1] {ECO:0000313|EMBL:CDH93609.2}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Spleen {ECO:0000313|EMBL:CDH93609.2};
RA Lee P.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDH93609.2}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Spleen {ECO:0000313|EMBL:CDH93609.2};
RA Lee P.T., Zou J., Holland J., Kanellos T., Secombes C.;
RT "Identification and characterization of fish specific TLR genes in Atlantic
RT salmon (Salmo salar).";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:XP_014004717.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; HG514146; CDH93609.2; -; mRNA.
DR RefSeq; XP_014004717.1; XM_014149242.1.
DR STRING; 8030.ENSSSAP00000035828; -.
DR PaxDb; 8030-ENSSSAP00000035828; -.
DR KEGG; sasa:106573839; -.
DR OrthoDB; 1207361at2759; -.
DR Proteomes; UP000087266; Chromosome ssa02.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_014004717.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..972
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010851456"
FT DOMAIN 814..957
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 972 AA; 110004 MW; 82B6F45D2CF4C8E9 CRC64;
MTFVFWVWRP GISVLLLLCV CDGAEGVIRH HCDCYEEDMY AQKDIGGLIQ CSLKPGLGPY
AECTRMTDLR SGLEEVFPDV RSLCILHSAS SLPADSFSHI PLLEHLYLDG SHLAKVTSGA
FAGLPKLRFL YILVSSSWGG VNVTLEPGVF QGLSSLEELT LAGMSLALAP PALLDPLVRV
RSLRVDQAGV RDLGELFCLL SPGMEKLETL ELPGSMVSSI QNRGCSGSNP WPTVLLSRIR
ILDLSGNPVR RVEPNSLSVF QNLSSLSLSM VDVWVGQLWG SGMGRVNRLY LSSYTLRQFT
PSLSDLCTLV VKHGVESLDL HQALITAFTA EVMKRCGPGL RQLSVTSEDL SGMDLGFWTG
TGQIQGLIMV LTKLTNASFC SAGGGRVWNL TSLILHGNHL TEITTDQFSC MPLLERLDLS
GNHISSLAHR ALQGMPLLRV LDLTHNKISL LGKDDFEGLP ALEVLLLEGN KISGGIAHGV
FRRQHRLQDL SLGEIDIIYQ LYLNMLFLGF PTKLQHLLID TGPGTYLTVG HVPAPEFPMV
LELRGKMIQS SDCDNNMFPM VRELKVGKGT TFDCKNLFLA PYFLNLESFE FSANPEKFAT
PYTTINQLRK LKRLKLTNLN FSNHTDPSVT FRNLTELRSL VLINCRLNFL TRSMFTDLVS
LRVLRLYSES PLILLEGVFI PLLSLSSLVF DQVDFRCDCS NGWLLDWADN SRKTQVVLLQ
QQQCIWHYQR LNFLSTMERL CQTEDDFLSY VSTTATVCTL LCLALGYRFL RWPCVVLFFR
LRGWVERRVG KRWWRRKRRM GGEGEEGEEK EEEVRYDAFV SFSSRDEAWV LGEMAPMLEE
EGEPRLRLCL HHRDFEVGKG IVDNIAENIY CSRRTVCVLT RRYLRSDWCG LEMRVATHRL
LSEHSHRLIL IFLEHISPFE LSAFHRLAKL ARTRTYLDWP QDEDERVTFW ERLRRNIAER
DADELHDPPE AS
//
