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Database: UniProt
Entry: W9ABQ2_9BACI
LinkDB: W9ABQ2_9BACI
Original site: W9ABQ2_9BACI 
ID   W9ABQ2_9BACI            Unreviewed;       799 AA.
AC   W9ABQ2;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   SubName: Full=Putative 3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:CDO03154.1};
GN   Name=fadN {ECO:0000313|EMBL:CDO03154.1};
GN   ORFNames=BN988_01655 {ECO:0000313|EMBL:CDO03154.1};
OS   Oceanobacillus picturae.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=171693 {ECO:0000313|EMBL:CDO03154.1, ECO:0000313|Proteomes:UP000028863};
RN   [1] {ECO:0000313|EMBL:CDO03154.1, ECO:0000313|Proteomes:UP000028863}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S1 {ECO:0000313|EMBL:CDO03154.1,
RC   ECO:0000313|Proteomes:UP000028863};
RA   Croce O., Lagier J.C., Raoult D.;
RT   "Draft genome sequencing of Oceanobacillus picturae strain S1 isolated from
RT   human gut.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDO03154.1, ECO:0000313|Proteomes:UP000028863}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S1 {ECO:0000313|EMBL:CDO03154.1,
RC   ECO:0000313|Proteomes:UP000028863};
RA   Urmite Genomes U.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDO03154.1}.
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DR   EMBL; CCAX010000001; CDO03154.1; -; Genomic_DNA.
DR   RefSeq; WP_036574878.1; NZ_CCAX010000001.1.
DR   AlphaFoldDB; W9ABQ2; -.
DR   STRING; 171693.BN988_01655; -.
DR   eggNOG; COG1024; Bacteria.
DR   eggNOG; COG1250; Bacteria.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000028863; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028863}.
FT   DOMAIN          8..205
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          208..305
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   799 AA;  88036 MW;  F76885A7C954D86B CRC64;
     MKQSIKRAAV LGSGVMGSGI AAHLANCGIH TIMLDIVPKE LTKEELAKGL SLEDKVVRNR
     IAAQSKKALL KQKPAALTTK KSLHLIEVGN MEDDMDKLAE VDWIVEVVVE SLPIKKKVFS
     RIDEIRKQGA IVSSNTSGIS VEKMAEDCSE DFKKHFLGTH FFNPPRYLKL LEIIPTVKTD
     PEVVAFMKKF SEDVLGKGVV EAKDTPNFIA NRIGTYGLLI TVRKMLEGGY SIGEVDSVTG
     PIIGRPKSAT FRTLDVVGLD TFIHVAKNVY DQVGGEEKEV FTVPDFMKEM LNRGWLGAKS
     GQGFFLKKKG KDGSAIYELN TETLEYEERK KLKSAAMEMA KQEKGTRRKL KALVNARGDR
     AGDLVWSMLK PVLLYSARLC GEIADDVLSI DQAMKWGFGW ELGPFETWDA IGVEASVTRM
     KEEGEDIPEW VENMLERGFS SFYKQENGSS FFYQKGEYTQ QEFNKKEIHL KRLKESNGVI
     KKNAGASFID LGDGVAGLEF HSQGNSIGLD IIQMMNYAIE ETEKNYEGLV IGNQGKNFCV
     GANLAMMLME AQDQNFMELD IVVRQFQNMA MRIKYAAKPV VAAPFNMVLG GGAEVSLPAA
     AIQASPETYI GLVEFGVGLI PGGGGTKELY LKQLRNLPKG IQFDLTKVAN DVFEKVATAT
     VSKSAAEARE NGFLNATDSI SANPDHLLYD AKEKVLALAK AGYQPKLPEQ IPVVGDSGYA
     AMLLGAQNLH RSGYASEHDV KIAEKLAYVL SGGRMKEGTV INEQAMLDLE REAFLSLIGE
     PLTQQRMQHM LVKGKPLRN
//
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