ID W9ABQ2_9BACI Unreviewed; 799 AA.
AC W9ABQ2;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Putative 3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:CDO03154.1};
GN Name=fadN {ECO:0000313|EMBL:CDO03154.1};
GN ORFNames=BN988_01655 {ECO:0000313|EMBL:CDO03154.1};
OS Oceanobacillus picturae.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX NCBI_TaxID=171693 {ECO:0000313|EMBL:CDO03154.1, ECO:0000313|Proteomes:UP000028863};
RN [1] {ECO:0000313|EMBL:CDO03154.1, ECO:0000313|Proteomes:UP000028863}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S1 {ECO:0000313|EMBL:CDO03154.1,
RC ECO:0000313|Proteomes:UP000028863};
RA Croce O., Lagier J.C., Raoult D.;
RT "Draft genome sequencing of Oceanobacillus picturae strain S1 isolated from
RT human gut.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDO03154.1, ECO:0000313|Proteomes:UP000028863}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S1 {ECO:0000313|EMBL:CDO03154.1,
RC ECO:0000313|Proteomes:UP000028863};
RA Urmite Genomes U.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDO03154.1}.
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DR EMBL; CCAX010000001; CDO03154.1; -; Genomic_DNA.
DR RefSeq; WP_036574878.1; NZ_CCAX010000001.1.
DR AlphaFoldDB; W9ABQ2; -.
DR STRING; 171693.BN988_01655; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000028863; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000028863}.
FT DOMAIN 8..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..305
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 799 AA; 88036 MW; F76885A7C954D86B CRC64;
MKQSIKRAAV LGSGVMGSGI AAHLANCGIH TIMLDIVPKE LTKEELAKGL SLEDKVVRNR
IAAQSKKALL KQKPAALTTK KSLHLIEVGN MEDDMDKLAE VDWIVEVVVE SLPIKKKVFS
RIDEIRKQGA IVSSNTSGIS VEKMAEDCSE DFKKHFLGTH FFNPPRYLKL LEIIPTVKTD
PEVVAFMKKF SEDVLGKGVV EAKDTPNFIA NRIGTYGLLI TVRKMLEGGY SIGEVDSVTG
PIIGRPKSAT FRTLDVVGLD TFIHVAKNVY DQVGGEEKEV FTVPDFMKEM LNRGWLGAKS
GQGFFLKKKG KDGSAIYELN TETLEYEERK KLKSAAMEMA KQEKGTRRKL KALVNARGDR
AGDLVWSMLK PVLLYSARLC GEIADDVLSI DQAMKWGFGW ELGPFETWDA IGVEASVTRM
KEEGEDIPEW VENMLERGFS SFYKQENGSS FFYQKGEYTQ QEFNKKEIHL KRLKESNGVI
KKNAGASFID LGDGVAGLEF HSQGNSIGLD IIQMMNYAIE ETEKNYEGLV IGNQGKNFCV
GANLAMMLME AQDQNFMELD IVVRQFQNMA MRIKYAAKPV VAAPFNMVLG GGAEVSLPAA
AIQASPETYI GLVEFGVGLI PGGGGTKELY LKQLRNLPKG IQFDLTKVAN DVFEKVATAT
VSKSAAEARE NGFLNATDSI SANPDHLLYD AKEKVLALAK AGYQPKLPEQ IPVVGDSGYA
AMLLGAQNLH RSGYASEHDV KIAEKLAYVL SGGRMKEGTV INEQAMLDLE REAFLSLIGE
PLTQQRMQHM LVKGKPLRN
//