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Database: UniProt
Entry: W9AR90_9MYCO
LinkDB: W9AR90_9MYCO
Original site: W9AR90_9MYCO 
ID   W9AR90_9MYCO            Unreviewed;       479 AA.
AC   W9AR90;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   27-SEP-2017, entry version 28.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:CDO08008.1};
GN   ORFNames=BN977_02827 {ECO:0000313|EMBL:CDO08008.1};
OS   Mycobacterium cosmeticum.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=258533 {ECO:0000313|EMBL:CDO08008.1, ECO:0000313|Proteomes:UP000028870};
RN   [1] {ECO:0000313|EMBL:CDO08008.1, ECO:0000313|Proteomes:UP000028870}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44829 {ECO:0000313|EMBL:CDO08008.1,
RC   ECO:0000313|Proteomes:UP000028870};
RA   Croce O., Robert C., Raoult D., Drancourt M.;
RT   "Draft Genome Sequence of Mycobacterium cosmeticum DSM 44829.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDO08008.1, ECO:0000313|Proteomes:UP000028870}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44829 {ECO:0000313|EMBL:CDO08008.1,
RC   ECO:0000313|Proteomes:UP000028870};
RA   Urmite Genomes U.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CDO08008.1}.
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DR   EMBL; CCBB010000001; CDO08008.1; -; Genomic_DNA.
DR   RefSeq; WP_036397928.1; NZ_CCBB010000001.1.
DR   EnsemblBacteria; CDO08008; CDO08008; BN977_02827.
DR   Proteomes; UP000028870; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028870};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028870}.
FT   DOMAIN      172    300       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      384    452       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     180    187       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   479 AA;  54028 MW;  7BA6838EA6D781F0 CRC64;
     MAADPDASFG TIWNNVVAEL TSALTPQQRA WLRMVQPLVI TEGFALLSVP TPFVQNEIER
     HLREPIVASL SRQLGQRVEL AVRISTPEPE PESAPVDPSP VADVEEVDDD LEARTSAEQS
     WPTFFNRQQP ASPEPDDVSL NRRYTFETFV IGASNRFAHA ATLAIAEAPA RAYNPLFIWG
     ESGLGKTHLL HAAGNYAQKL FPGMRVKYVS TEEFTNDFIN SLRDDRKASF KRSYRDIDVL
     LVDDIQFIEG KEGIQEEFFH TFNTLHNANK QIVISSDRPP KKLATLEDRL RTRFEWGLIT
     DVQPPELETR IAILRKKAQM DRLDVPDDVL ELIASRIERN IRELEGALIR VTAFASLSNT
     AIDKALAEIV LRDLIADAST VQISTATIMA VTAEYFETSI EELRGPGKTR ALAQARQIAM
     YLCRELTDLS LPKIGEAFGR DHTTVMYAER KIRDGMAERR EIFDHVKELT TRIRQRSKG
//
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