ID W9BQE9_KLEPN Unreviewed; 450 AA.
AC W9BQE9;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Metalloprotease PmbA {ECO:0000313|EMBL:OVF62577.1};
DE SubName: Full=Peptidase PmbA {ECO:0000313|EMBL:STT83490.1};
GN Name=pmbA {ECO:0000313|EMBL:MBD3717913.1};
GN ORFNames=B5L96_30905 {ECO:0000313|EMBL:OVF62577.1}, BL124_00000505
GN {ECO:0000313|EMBL:ROH05618.1}, CK244_008050
GN {ECO:0000313|EMBL:QBH42935.1}, DL426_03595
GN {ECO:0000313|EMBL:QDX69634.1}, DW281_21810
GN {ECO:0000313|EMBL:RDT85812.1}, EAO17_16515
GN {ECO:0000313|EMBL:RRF07696.1}, G4V31_04045
GN {ECO:0000313|EMBL:NGN71299.1}, G7Z27_24510
GN {ECO:0000313|EMBL:QLI10735.1}, GJJ08_024195
GN {ECO:0000313|EMBL:QOU51381.1}, GJJ13_022730
GN {ECO:0000313|EMBL:QOU78298.1}, GJJ18_15290
GN {ECO:0000313|EMBL:MRL36789.1}, GNF00_10965
GN {ECO:0000313|EMBL:MUA40370.1}, GS419_24315
GN {ECO:0000313|EMBL:QHD77097.1}, HJX03_24370
GN {ECO:0000313|EMBL:QJL31460.1}, IE995_04805
GN {ECO:0000313|EMBL:MBD3717913.1}, NCTC5047_04504
GN {ECO:0000313|EMBL:STT83490.1};
OS Klebsiella pneumoniae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=573 {ECO:0000313|EMBL:OVF62577.1, ECO:0000313|Proteomes:UP000196447};
RN [1] {ECO:0000313|EMBL:OVF62577.1, ECO:0000313|Proteomes:UP000196447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=39383 {ECO:0000313|EMBL:OVF62577.1,
RC ECO:0000313|Proteomes:UP000196447};
RA Fouts D., Stalin M.J., Chen L., Wright M., Sutton G., Nguyen K.,
RA Vanduin D., Rojas L., Hujer A., Hujer K., Bonomo R., Kreiswirth B.,
RA Adams M.;
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RRF07696.1, ECO:0000313|Proteomes:UP000275975}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KLPN_104 {ECO:0000313|EMBL:RRF07696.1,
RC ECO:0000313|Proteomes:UP000275975};
RX PubMed=30373801;
RA Tamma P.D., Fan Y., Bergman Y., Pertea G., Kazmi A., Lewis S.,
RA Carroll K.C., Schatz M.C., Timp W., Simner P.J.;
RT "Applying Rapid Whole Genome Sequencing to Predict Phenotypic Antimicrobial
RT Susceptibility Testing Results Among Carbapenem-Resistant Klebsiella
RT pneumoniae Clinical Isolates.";
RL Antimicrob. Agents Chemother. 0:0-0(2018).
RN [3] {ECO:0000313|EMBL:QDX69634.1, ECO:0000313|Proteomes:UP000320592}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DA12090 {ECO:0000313|EMBL:QDX69634.1,
RC ECO:0000313|Proteomes:UP000320592};
RA Sandegren L.;
RT "Genome sequence of Klebsiella pneumoniae DA12090 (CAS55).";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:STT83490.1, ECO:0000313|Proteomes:UP000254340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC5047 {ECO:0000313|EMBL:STT83490.1,
RC ECO:0000313|Proteomes:UP000254340};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:RDT85812.1, ECO:0000313|Proteomes:UP000254680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K280 {ECO:0000313|EMBL:RDT85812.1,
RC ECO:0000313|Proteomes:UP000254680};
RA He F.;
RT "Draft genome sequence of Klebsiella pneumoniae K280.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:ROH05618.1, ECO:0000313|Proteomes:UP000283322}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CRK0165 {ECO:0000313|EMBL:ROH05618.1,
RC ECO:0000313|Proteomes:UP000283322};
RA Vanduin D., Fouts D., Wright M., Sutton G., Nguyen K., Kreiswirth B.,
RA Chen L., Rojas L., Hujer A., Hujer K., Bonomo R., Adams M.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:QBH42935.1, ECO:0000313|Proteomes:UP000218354}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VBA2172 {ECO:0000313|EMBL:QBH42935.1,
RC ECO:0000313|Proteomes:UP000218354};
RA Veeraraghavan B., Shankar C., Vasudevan K., Venkatesan M., Narasimman V.;
RT "VBA2172 Klebsiella pneumoniae hybrid assembly.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:MRL36789.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CriePir115 {ECO:0000313|EMBL:MRL36789.1};
RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA Fomina V., Gusarov V., Zamyatin M., Shagin D.;
RT "Molecular typing, antibiotic resistance determination and virulence
RT profiling for 36 multidrug-resistant clinical Klebsiella pneumoniae
RT isolates using second- and third-generation sequencing.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:MUA40370.1, ECO:0000313|Proteomes:UP000485085}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KP_38044 {ECO:0000313|EMBL:MUA40370.1,
RC ECO:0000313|Proteomes:UP000485085};
RA Zhou K.;
RT "Emergence of a novel subclone of carbapenem-resistant Klebsiella
RT pneumoniae ST11 with enhanced virulence and transmissibility: a molecular
RT epidemiological, clinical, genomic study.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:QHD77097.1, ECO:0000313|Proteomes:UP000464108}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Kp36 {ECO:0000313|EMBL:QHD77097.1,
RC ECO:0000313|Proteomes:UP000464108};
RA Tan D.;
RT "Mobile Genetic Element-Mediated Frameshifting in wcaJ Provides Phage
RT Resistance in Klebsiella pneumoniae.";
RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|Proteomes:UP000438340, ECO:0000313|Proteomes:UP000439817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CriePir120 {ECO:0000313|EMBL:QOU51381.1,
RC ECO:0000313|Proteomes:UP000439817}, and CriePir45
RC {ECO:0000313|EMBL:QOU78298.1, ECO:0000313|Proteomes:UP000438340};
RX PubMed=32429555;
RA Shelenkov A., Mikhaylova Y., Yanushevich Y., Samoilov A., Petrova L.,
RA Fomina V., Gusarov V., Zamyatin M., Shagin D., Akimkin V.;
RT "Molecular Typing, Characterization of Antimicrobial Resistance, Virulence
RT Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella
RT pneumoniae Isolates.";
RL Antibiotics 9:E261-E261(2020).
RN [12] {ECO:0000313|EMBL:NGN71299.1, ECO:0000313|Proteomes:UP000479475}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2429 {ECO:0000313|EMBL:NGN71299.1,
RC ECO:0000313|Proteomes:UP000479475};
RA Starkova P.S., Sulyan O.S., Likholetova D.V., Ageevets V.A., Lazareva I.V.,
RA Sopova J.V., Sidorenko S.V.;
RT "Klebsiella pneumoniae genome sequencing and assembly.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:QLI10735.1, ECO:0000313|Proteomes:UP000509467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=11KM256 {ECO:0000313|EMBL:QLI10735.1,
RC ECO:0000313|Proteomes:UP000509467};
RA Brilhante M., Perreten V.;
RT "Whole genome sequencing of global problem clones of OXA-48-producing
RT Klebsiella pneumoniae from the veterinary setting in Switzerland.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:QJL31460.1, ECO:0000313|Proteomes:UP000503203}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C16KP0122 {ECO:0000313|EMBL:QJL31460.1,
RC ECO:0000313|Proteomes:UP000503203};
RA Yoon E.-J., Gwon B., Liu C., Kim D., Won D., Park S.G., Choi J.R.,
RA Jeong S.H.;
RT "Built-in CTX-M extended-spectrum beta-lactamase gene in Klebsiella
RT pneumoniae ensuring stable propagation of the multidrug-resistant pathogen
RT in clinical settings.";
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000313|EMBL:MBD3717913.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NK1661 {ECO:0000313|EMBL:MBD3717913.1};
RA Gomez-Simmonds A., Annavajhala M.K., Uhlemann A.-C.;
RT "Clinical and genomic characterization of carbapenemase-producing
RT Enterobacterales causing secondary infections during the COVID-19 crisis at
RT a New York City hospital.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Metalloprotease involved in CcdA degradation. Suppresses the
CC inhibitory activity of the carbon storage regulator (CsrA).
CC {ECO:0000256|ARBA:ARBA00025682}.
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; JACXTM010000001; MBD3717913.1; -; Genomic_DNA.
DR EMBL; WJWF01000013; MRL36789.1; -; Genomic_DNA.
DR EMBL; WNPO01000015; MUA40370.1; -; Genomic_DNA.
DR EMBL; JAAKYD010000003; NGN71299.1; -; Genomic_DNA.
DR EMBL; NDBK01000131; OVF62577.1; -; Genomic_DNA.
DR EMBL; CP036320; QBH42935.1; -; Genomic_DNA.
DR EMBL; CP030072; QDX69634.1; -; Genomic_DNA.
DR EMBL; CP047192; QHD77097.1; -; Genomic_DNA.
DR EMBL; CP052431; QJL31460.1; -; Genomic_DNA.
DR EMBL; CP049716; QLI10735.1; -; Genomic_DNA.
DR EMBL; CP063008; QOU51381.1; -; Genomic_DNA.
DR EMBL; CP063023; QOU78298.1; -; Genomic_DNA.
DR EMBL; QRCD01000027; RDT85812.1; -; Genomic_DNA.
DR EMBL; MPYG04000004; ROH05618.1; -; Genomic_DNA.
DR EMBL; RDAM01000001; RRF07696.1; -; Genomic_DNA.
DR EMBL; UGLH01000006; STT83490.1; -; Genomic_DNA.
DR RefSeq; WP_004152265.1; NZ_WYAM01000019.1.
DR KEGG; kpne:KU54_024155; -.
DR KEGG; kpnk:BN49_4806; -.
DR KEGG; kpnu:LI86_23995; -.
DR Proteomes; UP000196447; Unassembled WGS sequence.
DR Proteomes; UP000218354; Chromosome.
DR Proteomes; UP000254340; Unassembled WGS sequence.
DR Proteomes; UP000254680; Unassembled WGS sequence.
DR Proteomes; UP000275975; Unassembled WGS sequence.
DR Proteomes; UP000283322; Unassembled WGS sequence.
DR Proteomes; UP000320592; Chromosome.
DR Proteomes; UP000438340; Chromosome.
DR Proteomes; UP000439817; Chromosome.
DR Proteomes; UP000464108; Chromosome.
DR Proteomes; UP000479475; Unassembled WGS sequence.
DR Proteomes; UP000485085; Unassembled WGS sequence.
DR Proteomes; UP000503203; Chromosome.
DR Proteomes; UP000509467; Chromosome.
DR Proteomes; UP000653697; Unassembled WGS sequence.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR047657; PmbA.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR43421; METALLOPROTEASE PMBA; 1.
DR PANTHER; PTHR43421:SF1; METALLOPROTEASE PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:OVF62577.1};
KW Metalloprotease {ECO:0000313|EMBL:OVF62577.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:OVF62577.1}.
FT DOMAIN 36..100
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 128..234
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 242..449
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 450 AA; 48486 MW; 4E00CBAA9327AFC0 CRC64;
MALAMKVISQ VAQQRKTLEE AVTTALELAA GKSDGAEVSV SKTTGIGVST RYGEVENVEF
NSDGALGITV YHQNRKGSAS STDLSPDAIA RTVQAALDIA RYTSPDPFAG VADKDLLAFD
APDLDLFHPA EVSPDDAIEL AARAEQAALK ADKRITNTEG GSFNSHYGIK VFGNSHGMLQ
SYCSTRHSLS SCVIAEDDGD MERDYAYTIG RAIEDLQSPE WVGEECARRT LSRLAPRKLS
TMKAPVIFAN EVATGLFGHL VGAIAGGAVY RKSTFLLDSL GKQILPEWLT IEEHPHLLKG
LASTPFDSEG VRTERRDIVK DGVLTQWLLT NYSARKLGMK STGHAGGIHN WRINGRGLSF
AKMLKEMGTG LVVTELMGQG VSGVTGDYSR GASGFWVENG EIQYPVSEIT IAGNLKEMWR
NIVTIGDDIE TRSNIQCGSV LLPEMKIAGQ
//
