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Database: UniProt
Entry: W9FNF6_STRFL
LinkDB: W9FNF6_STRFL
Original site: W9FNF6_STRFL 
ID   W9FNF6_STRFL            Unreviewed;       783 AA.
AC   W9FNF6;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE            EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN   ORFNames=SSIG_02412 {ECO:0000313|EMBL:EWS91939.1};
OS   Streptomyces filamentosus NRRL 11379.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=457430 {ECO:0000313|EMBL:EWS91939.1, ECO:0000313|Proteomes:UP000027349};
RN   [1] {ECO:0000313|EMBL:EWS91939.1, ECO:0000313|Proteomes:UP000027349}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 11379 {ECO:0000313|EMBL:EWS91939.1,
RC   ECO:0000313|Proteomes:UP000027349};
RG   The Broad Institute Genome Sequencing Platform;
RA   Fischbach M., Ward D., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D.,
RA   Hepburn T., Sykes S., Godfrey P., Alvarado L., Kodira C.D., Straight P.,
RA   Clardy J., Hung D., Kolter R., Mekalanos J., Walker S., Walsh C.T.,
RA   Lander E., Galagan J., Nusbaum C., Birren B.;
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EWS91939.1, ECO:0000313|Proteomes:UP000027349}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 11379 {ECO:0000313|EMBL:EWS91939.1,
RC   ECO:0000313|Proteomes:UP000027349};
RA   Ward D., Fischbach M., Godfrey P., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Borenstein D., Chapman S.B., Chen Z., Engels R.,
RA   Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA   Heiman D.I., Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D.,
RA   Pearson M., Richards J., Roberts A., Saif S., Shea T.D., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C., Haas B.,
RA   Henn M.R., Nusbaum C., Birren B.;
RT   "The genome sequence of Streptomyces roseosporus strain NRRL 11379.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC         Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC         (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC         cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC         D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC         diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC         Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC         ChEBI:CHEBI:78435; EC=2.4.1.129;
CC         Evidence={ECO:0000256|ARBA:ARBA00023988};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EWS91939.1}.
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DR   EMBL; ABYX02000001; EWS91939.1; -; Genomic_DNA.
DR   AlphaFoldDB; W9FNF6; -.
DR   Proteomes; UP000027349; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR001264; Glyco_trans_51.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR036950; PBP_transglycosylase.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR32282:SF34; PENICILLIN-BINDING PROTEIN 1A; 1.
DR   Pfam; PF00912; Transgly; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF53955; Lysozyme-like; 1.
PE   4: Predicted;
KW   Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        80..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          124..299
FT                   /note="Glycosyl transferase family 51"
FT                   /evidence="ECO:0000259|Pfam:PF00912"
FT   DOMAIN          403..658
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          698..783
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..46
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..70
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        722..766
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   783 AA;  82357 MW;  563986F6ED7044E5 CRC64;
     MGELTTSQEP PTDMSDEPQS WAPRDSSGAG ASSGNHRPTA SGEQPGTNPG KPGKPGKPGK
     KARPRRTGWR RAIPTWRMTL GTLLGLVVLL GAGVFAAYRL VDIPAANASA TAQSNVYLYS
     DGSVIARDGD VNREKVKLSQ VPPTVQHAVL AAEDRDFYSD DRAVDVKAML RAGWNTVTGK
     GKQGGSTITQ QYVKNYYLGQ ERTVLRKAKE AIIAVKLNRE ETKDQIFEGY LNTSYFGRNA
     YGIQAAAQAY YGKNVEELTT AEGAYLASLL NAPSAYDVVA HPDNRPAAQR RWNYVLGGMV
     KERWLTAAER ATTRFPTPGE AKPSNGLSGQ RGYIVQAVED YLNRRGILDA KTLATGGYRI
     TTTLDKAKQD AFVKAVADNV TAKTSSNRAA DRNVRVGGAS IVPETGKVVA LYGGIDYTKQ
     YVSNATRRDY QVGSVFKPFV LTSAVVNDST TQDGRRITPN TVYDGTNKRT VVGVQGSTDY
     APANEDDVDY GDITVRIATD KSVNSVYAQM AQDVGPAKVR ETAIALGIPA DTPDLTAAPS
     IALGTANASV LDMAEAYATL ADHGRHGRYV LVEKVTKDGA EIELPERTTE QAVSREAADT
     TTAVLRSVVE GGTGTAAQTV GRPAVGKTGT AEEDRAAWFA GYTPDLASVV AVMGQNPDTG
     AQTPLYGALG LPRVNGGGVP AETWAAYTEA ALRSSPVQEF DLRTAPGSDE GDELLVDENA
     DGGTDPSSSS DPDTSPDTSP DATPGTTPDG SAPPTPGTNT GGTDEGSVSA PDGIGDGDGD
     GNG
//
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