ID W9G2S6_9MICO Unreviewed; 1138 AA.
AC W9G2S6;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=N865_16320 {ECO:0000313|EMBL:EWT00305.1};
OS Intrasporangium oryzae NRRL B-24470.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC Intrasporangium.
OX NCBI_TaxID=1386089 {ECO:0000313|EMBL:EWT00305.1, ECO:0000313|Proteomes:UP000019489};
RN [1] {ECO:0000313|EMBL:EWT00305.1, ECO:0000313|Proteomes:UP000019489}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-24470 {ECO:0000313|EMBL:EWT00305.1,
RC ECO:0000313|Proteomes:UP000019489};
RA Liu H., Wang G.;
RT "Intrasporangium oryzae NRRL B-24470.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWT00305.1}.
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DR EMBL; AWSA01000047; EWT00305.1; -; Genomic_DNA.
DR AlphaFoldDB; W9G2S6; -.
DR STRING; 1386089.N865_16320; -.
DR PATRIC; fig|1386089.3.peg.3459; -.
DR eggNOG; COG0210; Bacteria.
DR eggNOG; COG2887; Bacteria.
DR Proteomes; UP000019489; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000019489}.
FT DOMAIN 17..355
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 356..708
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1138 AA; 121810 MW; A6313704633A4AF8 CRC64;
MSPRYSALDI ARALDKPEPT PEQQAVIESG PRPLLVVAGA GSGKTETMAA RVVWLVANGL
VEPDQVLGLT FTRKAAAELS QRITQRLRAL VRAGLWTPPA DDGTGAEVLG GTPTVSTYHA
YAGRLVREHA LRVGIEPEFR MLTEAGAWQL AAEAVSRYDG PMDEVTKAES TVIDAVMSLA
GEMAEHVRTP DEVLAHLDEV IGRIEALPDG EGRGSLTGVR DALAVLRERR AVLPIVKRYL
DLKREKESLD FADQMAVAAR LSGSVAHVGE VERARFRAVL LDEFQDTSEA QLSLLRSLFH
GGSEPVALTA VGDPNQSIYG WRGASATTLA RFPAELADET GPAAVLPLST SWRNDALILD
AANITAAPLA AAHVEPLTAR PGAGGGSIAV ARLASIEDEA AHVADWVASG WRSPSGRRTG
RTAAVLCRRR SHFPFVIDAL RARGLPVEVV GLGGLLMTPE IGDLVATLWV VQDPSRGDQL
MRLLTGPVAR LGTADLDGLW AWAKELHARP WRVGRAPAVQ PMLALDTGRA EPERVQGAVA
LLEPDDDAGG SADAAERHTA DLAADSADTA TLVEALGELP RPGWVGHGGV TISDGALSRL
SALSDVLAGL RRMTALPLVD LVSEAERAVG LDIEVLSRPE HTASTARVHL DAFADVAARF
AMSSDRPTLA GFLGWLEAAR EQERGLDAGH VETDADAVQV LTIHAAKGLE WDLVAVPALV
ESVFPDHKAT TVGLVDGEWS CTGQPKDFGW LTGIDSVPYD LRGDRDGLPH LDWRGAPDRK
ALGRAVDDFA LDGGAHAIAE ERRLAYVAFT RARSAMLLST HFWGATKKGL SVESRFLREI
RLALGARLVT TTWAPDPEPV TDDKGRPVAP DNPFLAHAVA AEFPYDPMGA RRVELARVVD
RLVELGTSAD LSVAVGDPRH DDLRLLLAEE AGRRGRGDVV VDVPRHLSAS AVVSFARDPE
AFAMTLRRPM PGPPAVAARQ GTAFHAWIEQ HYARAAIVDV FDLPGSADEE AASDVSLARL
KELFLQSEWV DRMPEEIEMS IETIIDGIAV RGRIDAVFPR ADGGWTVVDW KTGVRPSGRE
AEVRAVQLGA YALAYARLRG VDPSRVDAAF YYAAEGVTVR PEVPDEATLS GLLQTLPV
//
