ID W9JPW4_FUSOX Unreviewed; 930 AA.
AC W9JPW4;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Prostaglandin-endoperoxide synthase 1 {ECO:0000313|EMBL:EWZ31670.1};
GN ORFNames=FOZG_14786 {ECO:0000313|EMBL:EWZ31670.1};
OS Fusarium oxysporum Fo47.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=660027 {ECO:0000313|EMBL:EWZ31670.1};
RN [1] {ECO:0000313|EMBL:EWZ31670.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fo47 {ECO:0000313|EMBL:EWZ31670.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Gale L.R., Schwartz D.C., Zhou S., Corby-Kistler H., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusarium oxysporum Fo47.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EWZ31670.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Fo47 {ECO:0000313|EMBL:EWZ31670.1};
RG The Broad Institute Genomics Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "Annotation of the Genome Sequence of Fusarium oxysporum Fo47.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JH717907; EWZ31670.1; -; Genomic_DNA.
DR AlphaFoldDB; W9JPW4; -.
DR VEuPathDB; FungiDB:FOZG_14786; -.
DR HOGENOM; CLU_002329_1_1_1; -.
DR Proteomes; UP000030766; Unassembled WGS sequence.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProt.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd09817; linoleate_diol_synthase_like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR InterPro; IPR036396; Cyt_P450_sf.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR InterPro; IPR034812; Ppo-like_N.
DR PANTHER; PTHR11903:SF13; LINOLEATE 10R-LIPOXYGENASE; 1.
DR PANTHER; PTHR11903; PROSTAGLANDIN G/H SYNTHASE; 1.
DR Pfam; PF03098; An_peroxidase; 2.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00022964}.
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 408
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 930 AA; 104738 MW; 3AE3A8B8554BD051 CRC64;
MAEHKNGVAT NGYEKKSSPA SSSTKSEAKP LPNGDKKDGI VRSFKQLRVA SKRPLPKEMG
DGSYRVVENR PGLKQDIRRL RGRDLKTLLE IVKAKVKGET QQDDKTMIME RTIQLVANLS
DHSKVQESLT NSFISQLWNS IDHPPMLYMG DKFRFRQPDG SNNNPYLPQL GAARTPYSRT
VRPKGMSLGA QPDPEAIFES VFARDAFRKN PNNVSSILWY WATIIIHDLF WTNLQDPNQN
DSSSYLDLAP LYGSTEKDRD SIRTFKDGQL KPDCFADKRL IGNPPGVPIL LIMFNRFHNH
VATNLADINE GSRFSKPAEH LSPEAADAAW KKRDTELFET ARLVTSGLYI NITLIDYVRN
IINLNRVDTT WTLDPRQEMG VSVGTKDLSE SGTGNVVSAE FNLCYRWHSC LSEMDDKWVQ
DFYTELLGEN YGPMNLQTMM KALKAFEASV ADEPSERTFG GFKRGPDGKF NDDELVEALA
TAIEQPGGAF GGRNVPRIMK PIEMLGIMRG RKWNLAGLNE FRKHFGLKAY ETFEDINSDP
SVADALRNLY QHPDYVELYP GIVAEEAKTP MVPGVGIAPT YTISRVVLSD AVALVRGDRY
YTTDYNPRHL TNWGYKEVDY DLKVNHGCVF YKLFLRAFPQ HFKGNSVYAH YPMVIPSENK
KILTNIKRAD RFDFSRPEPT ATRINIIGYN AAKYILEDQQ KYRVCWEEGL KHLMGEAGGR
FMLSGDTALH AQQRKCMGKL LYNDTWRNAV KSFYATTAEK LLAEKSYRLA GKTQVDVVRD
VGNVAHTHFV ARMFNLPLKT SENPKGVFSE QELYMILAVI FVCIFFDIDP AKSFPLRQGA
REVAQKLGGI IEMNVKLANS IGVKGLFTSK PDKNDDPLAR YGENMAKGLK KAGLSTEDIV
WSQILPTAGA MVPNQAQVVS QTSPTRQLSE
//
