ID W9KWI5_FUSOX Unreviewed; 1159 AA.
AC W9KWI5;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=FOZG_05779 {ECO:0000313|EMBL:EWZ45468.1};
OS Fusarium oxysporum Fo47.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=660027 {ECO:0000313|EMBL:EWZ45468.1};
RN [1] {ECO:0000313|EMBL:EWZ45468.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fo47 {ECO:0000313|EMBL:EWZ45468.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Gale L.R., Schwartz D.C., Zhou S., Corby-Kistler H., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusarium oxysporum Fo47.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EWZ45468.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Fo47 {ECO:0000313|EMBL:EWZ45468.1};
RG The Broad Institute Genomics Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "Annotation of the Genome Sequence of Fusarium oxysporum Fo47.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR EMBL; JH717898; EWZ45468.1; -; Genomic_DNA.
DR AlphaFoldDB; W9KWI5; -.
DR VEuPathDB; FungiDB:FOZG_05779; -.
DR HOGENOM; CLU_003532_2_1_1; -.
DR Proteomes; UP000030766; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF644; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 73..203
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 229..550
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
SQ SEQUENCE 1159 AA; 134513 MW; D179A23EA762AF73 CRC64;
MTHDINSPND MVMDTDDYIG VANEPEKVAI INPDNLEQSE VDQLQDLPMA NDHEAMREIC
LPPLIDEPKI LGDYEYTWTV ENWRSLNKKE HGPVFQAGGF PWRILLFPHG NNIDQCSIYL
EHGFDADSVP DNWSCCVQFA LVLWNPNDPS LYVHHTAHHR FTKEEGDWGF TRFVEHRRMF
NVPWEGSSRP LCENDTANIT AYLRLVEDET GVLWHNFANY DSKKETGYVG LKNQGATCYL
NSLMQSLYFT NKFRKAIYEI PTEADPSMTN SAYTLQRLFY QLQTSDQAVG TTELTKSFGW
DTRHIFEQQD VQEFSRKLME RMEDKMKGTA SENVLPEMFS GKIKTYISCI NVDYESSRIE
DFWDIQLNVS GNKHLLESFE DYVQVEKMDG ENQYFAGDQY KLQDANKGVI FNSFPDVLHL
QLKRFEYDIQ RDTMMKINDR YEFPEFFDAA PYLSEDADKS VPWTYQLHSV LVHSGDLNAG
HYYAFLKPEK DGWFYKYDDD KVTKATMREV LEENFGGEYQ TSNGYPRAPV QKKAPIMRQN
SAYMLVYIRQ SRIDDILCPV TKDHIPLHLR QKFEEETVQR EARKKEQREA HLYMWAKVIT
DYSFQQYGGT DLCQFDAKPE DPAAPKFYRV RRAMTMEEFV AQVASDMGED PRRVRLWLMV
NRQNKTVRPD QPIMDLRPTV DETFSRSAAH RDASLRVWAE VAEEVNADGE PIWPSYQSQP
NGVIVKNDTI LLLLKHFDID AQTLRGVGHV YISKDKKVEE LLPMILKKMG WGEKLPAEEK
LLLWEEIKPT MIEPLKPKQS LKVAELQDGD IICFQRTKAG VEKRAGEKTS QETNTSDHFE
DAREYYDFLE NRRTVKFHPH PARCDQAQYP PFDLVLNTKI TYDTLSERVG AYLDVKPTHI
RFWTVNASTQ NPKTPVRRGA NPTLRQILSP MGSTALNSTQ RDDAFYFEVL EMSLTELDTK
KSIKVNLLSE GITKEDTYDL LVPKTGTIDD LVEVLIRKAQ IPSETDGGRI RIYETSSNRF
YREPLREHPV INLNEFAKIY AERVPQEELN ADDTHFIHVF HFHNDVSRVH GVPFKFLVIE
GESFADTKKR LEKRTGIKGK SFEKIKIAVV RRANYSKPQY LNDDDVLSSF IQGEDDYLGL
DHVDRTRTLR NGVGDLFLK
//