ID W9NHN8_FUSOX Unreviewed; 1007 AA.
AC W9NHN8;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Trehalase {ECO:0000256|RuleBase:RU361180};
DE EC=3.2.1.28 {ECO:0000256|RuleBase:RU361180};
DE AltName: Full=Alpha-trehalose glucohydrolase {ECO:0000256|RuleBase:RU361180};
GN ORFNames=FOVG_16494 {ECO:0000313|EMBL:EXA32219.1};
OS Fusarium oxysporum f. sp. pisi HDV247.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1080344 {ECO:0000313|EMBL:EXA32219.1};
RN [1] {ECO:0000313|EMBL:EXA32219.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HDV247 {ECO:0000313|EMBL:EXA32219.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Gale L.R., Schwartz D.C., Zhou S., Corby-Kistler H., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusarium oxysporum HDV247.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EXA32219.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HDV247 {ECO:0000313|EMBL:EXA32219.1};
RG The Broad Institute Genomics Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "Annotation of the Genome Sequence of Fusarium oxysporum HDV247.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
CC Evidence={ECO:0000256|ARBA:ARBA00001576,
CC ECO:0000256|RuleBase:RU361180};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
CC {ECO:0000256|ARBA:ARBA00005615, ECO:0000256|RuleBase:RU361180}.
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DR EMBL; JH650998; EXA32219.1; -; Genomic_DNA.
DR AlphaFoldDB; W9NHN8; -.
DR HOGENOM; CLU_006451_1_0_1; -.
DR Proteomes; UP000030751; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:UniProtKB-EC.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005993; P:trehalose catabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR001661; Glyco_hydro_37.
DR InterPro; IPR018232; Glyco_hydro_37_CS.
DR InterPro; IPR011120; Trehalase_Ca-bd.
DR PANTHER; PTHR23403:SF6; CYTOSOLIC NEUTRAL TREHALASE-RELATED; 1.
DR PANTHER; PTHR23403; TREHALASE; 1.
DR Pfam; PF01204; Trehalase; 1.
DR Pfam; PF07492; Trehalase_Ca-bi; 1.
DR PRINTS; PR00744; GLHYDRLASE37.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR PROSITE; PS00928; TREHALASE_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361180}.
FT DOMAIN 354..383
FT /note="Neutral trehalase Ca2+ binding"
FT /evidence="ECO:0000259|Pfam:PF07492"
SQ SEQUENCE 1007 AA; 114463 MW; 30CBF73B90B6A9EA CRC64;
MNLLLTGSRI TVMDGLGIVA NIAAVLDLSA KVATLCFQYS TTVASARGDI KRLQSHVNGL
AVALRAGKQL VEGPNSRPLV ASRELAASLQ VCTDELRRVH NKLDPGTGHE AMHRFGLRAL
KWPFNSKELE GIITNLERHE KTILLGLQID QTNLLLRISE RIEGMALKAT HDMSIARKPN
FVICSYEQLL QPAVNLVVPQ QPVILPGYIP IAIHPPNEVG AARSRQDGHE QPKSTAVPCG
LTLLPSGYLS PPCSTFKKTG LKSDTLMTLP TSPRNHVACS SEDLGVFDDA KISYSSLERH
FNKACPRSRT YSQNSLLNRF RRLGSTEPFR RGSHNGFMRY TYPRRFLIQV DVVLESLQKQ
EDTDKNMQIT IEDNGPKVLT LRTAASGGHN RFDVRGTYML SNLLQELTLA KWYGRKQIVL
DEARLNENPV DRLSRLIRDY FWENLTRQLD GFTIDLAARD PKDWTDDPRP RIYIPVGAPE
QFEYYQQVAK DRPELRLDVQ LLPETITPQL VRDMNDKPGV LALAMETVKD PETGKETLKG
LPFVVPGGKF NELYGWDSYM IILGLLADGK VDLAKSIVRN FCFCIKHYGK VLNATRSYYL
CRSQPPFLTD MALRVYEKIK HEPDAKEFLR MALLASIREY YNIWVAEPRL DPITGLSRYR
PEGLGVPPEA EASHFAHILE PYAKKYGMTW QDFVKAYNRE EIKEPELDEY FMHDRAMRES
GHTTSYRLER VCANLATIDL NSLLFKYETD IAKTIRNVFG DKLVIPEEFN VSALKSGSVV
TSAFWDRRSR RRKLAINKYL WNEDKGMYFD YDTVKKEQTV YESATTFWAL WAGVSTPKQA
ANMVLKALPK FEAFGGLLSG TEMSRGNITL KRPNRQWDYP YGWAPQQILA WMGLARYSFD
EESERLAYKW LFVIIKGFAE FNGTVVQKYD ITRPLDPHRV DAEYGNQGLD FKGVATEGFG
WVNASYVYGL QTITTHMRRA LGTVTPYETL SRAFRQLELK DLAELTP
//
