ID W9PBP8_FUSOX Unreviewed; 1214 AA.
AC W9PBP8;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=FOVG_07712 {ECO:0000313|EMBL:EXA42493.1};
OS Fusarium oxysporum f. sp. pisi HDV247.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1080344 {ECO:0000313|EMBL:EXA42493.1};
RN [1] {ECO:0000313|EMBL:EXA42493.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HDV247 {ECO:0000313|EMBL:EXA42493.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Gale L.R., Schwartz D.C., Zhou S., Corby-Kistler H., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusarium oxysporum HDV247.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EXA42493.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HDV247 {ECO:0000313|EMBL:EXA42493.1};
RG The Broad Institute Genomics Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "Annotation of the Genome Sequence of Fusarium oxysporum HDV247.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JH650972; EXA42492.1; -; Genomic_DNA.
DR EMBL; JH650972; EXA42493.1; -; Genomic_DNA.
DR HOGENOM; CLU_002173_5_1_1; -.
DR Proteomes; UP000030751; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EXA42493.1};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 867..1214
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1182
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1214 AA; 137250 MW; 8B4BF15B49D22E2C CRC64;
MAPWSSRRGS QPNNNSNGDL ISRIHNTALH TPTTLPALYS TNLPNTSNGN RLELSFSNAN
ADSSSDESDL HPSRPQSSKP RRPQHTRSMS QPFPSLFSSK KKRQNSVGAP PPDLGFADDD
SAMPRQAPKT HARNPSHTRN GPVGSKDFTT GNCMTCGSLV RWPRELKVFK CTICTTVNDL
EPLSADHDGS KSRRDASQDP TQSVPTRGPH ISIEQTKRLV QQSIQSFLSK KLHSIPEPPI
EAPPQPPPQS KLSFSSRMQA AGQSLAPVDF RQEAAPSSES PTIQVSHYAF DEEPTLRSSP
ARPNPTPMRS FSSSYTERPP VRKILQERGP KEPKEQRKLP DQSEGDPKRI FKALEDYIVA
CFGSFECINS SFLTHTHRQP IRCRSESTRR KPILPSEPRE QRGHRREPSG NHAAREPREE
QCTPQFEDGS CDLDPKLLLL GDFAENGTWW MGNQEDSRPR RPATNRVERS FSNAPVNTKT
PQMSWGDLIK WYTTIVNPAE GWFAIYEEMC QGKGFLTPSQ RELQLMEREL LQGQEHARRV
LLKATEMLLR RPGRPLKDPA DLRFLLIILE NPLLHEHETL FRGILQFEKN LPSGPRSIQQ
RKASTPESGP LSGQHSGIIK RIVGLVSNSS AECHNQLIAW FSRHHPSRFI RTKELASGFL
TYRMIRQSGK KQEVKVDITA GLIPQMQEGR SGAYLYDEIH RANSSKKAKE PEKKIMYAED
WQIRASSRVL ALLFAANNLP HSRRNEESPS GSAEGRSNVH SHGQILPTSD FYNSMIDYTD
LLADFENWEA RRSKFTFCQY PFLLSIWAKN HILEHDARRQ MQSKARDAFF DSIMSRKAIN
QFLELTVRRD CLVDDSLKAV SEVIGSGSED IKKGLRITFS GEEGVDAGGL RKEWFLLLAR
EVFNPDHGLF LYDEDSQYCY FNPNAFETSD QFFLVGVVMG LAIYNSTILD VALPPFAFRK
LIASAPTHGT GASAHPRPPM RYTLEDLAEY RPRLARGLRQ LLEYEGNVED TFCLDFVIDM
DKYGTQVQVP LCPGGERIPV TNSNRREYVD LYVRYIIDVS VTRQFEPFKR GFYTVCGGNA
LSLFRPEEIE LLVRGSDESL DINSLRGVAE YDNWGTKKPD GSEPVIDWFW ETFQAATSQD
QRKLLLFITG SDRIPAMGAA VLPIKISCLG EDEGRFPIAR TCFNMLSLSR YKSKERLEKL
LWTAVHESEG FGIK
//
