ID W9PEQ8_FUSOX Unreviewed; 2374 AA.
AC W9PEQ8;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Serine/threonine-protein kinase TOR {ECO:0000256|RuleBase:RU364109};
DE EC=2.7.11.1 {ECO:0000256|RuleBase:RU364109};
GN ORFNames=FOVG_09941 {ECO:0000313|EMBL:EXA41461.1};
OS Fusarium oxysporum f. sp. pisi HDV247.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1080344 {ECO:0000313|EMBL:EXA41461.1};
RN [1] {ECO:0000313|EMBL:EXA41461.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HDV247 {ECO:0000313|EMBL:EXA41461.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Gale L.R., Schwartz D.C., Zhou S., Corby-Kistler H., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusarium oxysporum HDV247.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EXA41461.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HDV247 {ECO:0000313|EMBL:EXA41461.1};
RG The Broad Institute Genomics Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "Annotation of the Genome Sequence of Fusarium oxysporum HDV247.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775,
CC ECO:0000256|RuleBase:RU364109};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031, ECO:0000256|RuleBase:RU364109}.
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DR EMBL; JH650973; EXA41461.1; -; Genomic_DNA.
DR Proteomes; UP000030751; Unassembled WGS sequence.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd05169; PIKKc_TOR; 1.
DR Gene3D; 1.20.120.150; FKBP12-rapamycin binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR009076; FRB_dom.
DR InterPro; IPR036738; FRB_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024585; mTOR_dom.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR026683; TOR_cat.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF9; SERINE_THREONINE-PROTEIN KINASE MTOR; 1.
DR Pfam; PF11865; DUF3385; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF08771; FRB_dom; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01346; DUF3385; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47212; FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU364109};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU364109};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU364109};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU364109};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364109}.
FT DOMAIN 1242..1842
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2017..2340
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 2327..2374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2327..2358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2374 AA; 268391 MW; BD7B3B453EA61A18 CRC64;
MAQAQQVALD RLDNISRALK SRTSDDLRKR SAVQLRELVA VCHRDLSPEQ FQVFYNAVNN
RITQLITHGN DSSERLGGIY ALDALIDFDG VDVGVKYTRF TQNLKTILRG KDINPMQPAA
IALGKLCRPG GAMISEVVDS EVNTALEWLQ NDRIEERRYS AVLVLRELAR SAPTLMYQYI
PTIFDWIWVG LRDPRQLIRA TSAETVSACF RILRERDQEM KQIWMDKIYN EARSGLKVNT
VESIHGSLLV LKELLEQGAM YMQEHYQEAC EIVFKHKDHR DPTIRKTVVL LIPDLASYSP
ADFAHTWLHK FMVYLSGMLK KDKERNDAFL AIGNIANSVK SAIAPYLDGV LIYVREGLSL
QSRKRGSVDP VFDCISRLAV AVGQTLSKYM EALLDPIFAC DLTPKLTQAL VDMAFYIPPV
KPTIQERLLD MLSVVLCGEP FKPLGAPQPN TLSSVPIIPK DAKDPHAYEH RRAEVKLALN
TLGSFDFSGH VLNEFVRDVA IKYVEDEDPE IREAAALTCC QLYVRDPIVN QTSYHALQVV
GDVIEKLLTV GVSDPEPNIR RTVLAALDER FDRHLAKAEN IRILFFALND EVFSIREVAI
SIIGRLARYN PAYVIPSLRK TLIQMLTELE FSDVARNKEE SAKLLSLLVQ NAQSLIKPYV
EPMISVLLPK AKDSNPSVAA TILKAIGELA TVGGEDMMPY KDRLMPIILD ALQDQSSNAK
RGAALHALGQ LASNSGYVIQ PYIEYPQLLE ILQSIIRTEG QQVPLRQETI KLMGILGALD
PYKHQAEERT PDSRRGEANQ LTDISLMMTG LTPSNKEYFP TVVINALLQI LKDSSLVQHH
AAVIEAIMNI FRTLGLECVS FLDRIIPAFL QVIRSATSTR LESYFNQLAT LVSIVRQHIR
NYLPSIVEIL QEYWHTSPSL QTTILSLVEA ISRSLEGEFK IYLAGLLPLM LGVLDKDTSA
KRTPSERVMH AFLVFGASAE EYMHLIIPVI VRTFEKQGQP TFIRKQAIDT IGKISRQVNL
NDFAAKIIHP LTRVLDMGEP VLRTAALDTL CALIQQLGKD YLHFMGTVNK TINQHQIQHS
NYELLVSKLQ KGEVLPQDLS SGAGFADGAD ETPFADQGTK KLEMNAIHLK AAWDTKGKST
KEDWQEWLRR FSTTLLTESP NHALRACASL ASVYLPLARE LFNSAFVSCW SELYEQFQDE
LIQNIESAIK SENVPPDLLG LLLNLAEFME HDDKALPIDI RVLGREAARC HAYAKALHYK
ELEFLQDQSS GAVEALIVIN NQLQQSDAAI GILRKAQLYK EGIQLRETWF EKLERWEEAL
AFYEKREEEV PEDQAIPVDI VMGKMRCLHA LGEWEALASL TGSTWANSTP EVQRMIAPLA
TAAAWGLNKW DSMDNYLSSL KRYSPDRSFF GAILALHRNQ FREAIACVQQ AREGLDTELS
ALVSESYNRA YQVVVRVQML AELEELIVYK QCDEKKQAIM RRTWETRLKG CQRNVEVWQR
MLRLRAIVIA PTENMHMWIK FANLCRKSGR MGLAEKSLKQ LIGTDAPLIS AIPYWNEQRQ
PAPNSRAAPA AQVIYAVLKY QWELGQQLPV NKKGNIPEKT LYCLRKFTND AAHRLEVARA
HLAAQAGNDV NITGDYGFQN PMDPSLISPH TSRALYDQTV LLAKCYLRQG EWLIALNKDD
WQYTQVQDIL LSYSQATKYN PRWYKAWHAW ALANFEIVQT LTAGNEGHLS RTDHNMVIDH
VVPAVKGFFK SIALSQGSSL QDTLRLLTLW FTHGGSSDVN VAVTEGFANV SVDTWLEVIP
QLIARINQPN KRVQQSVHNL LADVGRAHPQ ALVYPLTVAM KSWQNTRRSR SAAQIMDSMR
QHSANLVAQA DIVSHELIRV AVLWHELWHE GLEEASRLYF GDSNIEGMFA TLAPLHELLE
RGPETLREIS FAQAFGRDLK EAQDWCRQYE TSQDVNDLNQ AWDLYYQVFR RISRQLPQVT
TLELTYCSPK LLNAKNLDLA VPGTYKSGQP IVRIMSFDTT FSVINSKQRP RKLNVNGSDG
KSYAFLLKGH EDIRQDERVM QLFGLCNTLL AHDSECFKRH LNIQRYPAIP LSQNSGLLGW
VPNSDTLHVL IREYRESRKI LLNIEHRIML QMAPDYDNLT LMQKVEVFGY ALDNTTGQDL
YRVLWLKSKS SEAWLERRTN YTRSLGVMSM VGYILGLGDR HPSNLMLDRV TGKIIHIDFG
DCFEVAMKRE KYPERVPFRL TRMLTYAMEV SNIEGSFRIT CENVMRVLRD NKESVMAVLE
AVSHPPLQID TSHTDIHSSS MILSLHGVSQ TPHPQQAPTS TLIATQPCPS QAESARVANP
SSTATSRQVN SSTPLNHQFR PAHAPEQTVQ RARP
//